Detailed information NTG0403381

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: GL188_RS11390
• Genome accession: NZ_CP046359
• Coordinates: 476298..476885 (-)
• Length: 195 a.a.
• NCBI ID: WP_000205166.1
• Uniprot ID: Q9ETN5
• Organism: Streptococcus pneumoniae strain 573
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 471298..481885

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
GL188_RS02420 (GL188_02500)	-	471760..473100 (+)	1341	WP_001017642.1	sensor histidine kinase	-
GL188_RS02425 (GL188_02505)	blpC	473171..473299 (-)	129	WP_000358815.1	quorum-sensing system pheromone BlpC	-
GL188_RS02430 (GL188_02510)	-	473356..474717 (-)	1362	WP_197097175.1	bacteriocin secretion accessory protein	-
GL188_RS02435 (GL188_02515)	comA/nlmT	474728..476404 (-)	1677	WP_215729172.1	peptide cleavage/export ABC transporter	Regulator
GL188_RS11390	comA/nlmT	476298..476885 (-)	588	WP_000205166.1	cysteine peptidase family C39 domain-containing protein	Regulator
GL188_RS02445 (GL188_02520)	blpI	477167..477364 (+)	198	WP_001093259.1	bacteriocin-like peptide BlpI	-
GL188_RS02450 (GL188_02525)	blpJ	477831..478100 (+)	270	WP_001093248.1	bacteriocin-like peptide BlpJ	-
GL188_RS02455 (GL188_02530)	blpK	478169..478417 (+)	249	WP_000379965.1	bacteriocin-like peptide BlpK	-
GL188_RS02460 (GL188_02535)	cipB	478661..478810 (+)	150	WP_001809846.1	bacteriocin-like peptide BlpO	Regulator
GL188_RS02465 (GL188_02540)	-	478914..479033 (+)	120	WP_000346296.1	PncF family bacteriocin immunity protein	-
GL188_RS02470 (GL188_02550)	-	479514..479872 (+)	359	Protein_494	immunity protein	-
GL188_RS02475 (GL188_02555)	-	480501..480884 (+)	384	WP_000877381.1	hypothetical protein	-
GL188_RS02480 (GL188_02560)	-	480936..481625 (+)	690	WP_000760532.1	CPBP family intramembrane glutamic endopeptidase	-

Sequence

Protein

• Length: 195 a.a.
• Molecular weight: 22270.71 Da
• Isoelectric Point: 9.6188

>NTDB_id=403381 GL188_RS11390 WP_000205166.1 476298..476885(-) (comA/nlmT) [Streptococcus pneumoniae strain 573]
MTSYKRTFVPQIDARDCGVAALASIAKFYGSDFSLAHLRELAKTNKEGTTALGIVKAADEMGFETRPVQADKTLFDMSDV
PYPFIVHVNKEGKLQHYYVVYQTKKDYLIIGDPDPSVKITKMSKERFFYEWTGVAIFLATKPSYQPHKDKKNGLLSKLPS
SDFQTKISHCLHCSLKLIGHYYQYRWFLLSPRNLG

Nucleotide

• Length: 588 bp

>NTDB_id=403381 GL188_RS11390 WP_000205166.1 476298..476885(-) (comA/nlmT) [Streptococcus pneumoniae strain 573]
ATGACTTCTTATAAACGTACATTTGTTCCTCAAATAGATGCGAGAGACTGTGGTGTCGCTGCCTTAGCCTCGATTGCTAA
ATTCTATGGTTCAGATTTTTCTCTAGCTCACTTGAGAGAACTTGCAAAGACCAATAAAGAAGGGACGACTGCTCTTGGCA
TTGTAAAAGCCGCTGATGAAATGGGCTTTGAAACAAGACCTGTTCAAGCAGATAAAACGCTCTTTGACATGAGTGATGTC
CCCTATCCATTTATCGTTCACGTTAACAAAGAAGGAAAACTCCAACATTACTATGTTGTCTATCAAACAAAGAAAGACTA
TCTGATTATTGGTGATCCTGACCCTTCTGTAAAAATCACTAAAATGTCAAAAGAACGCTTTTTCTATGAATGGACTGGAG
TAGCTATTTTTCTAGCTACCAAACCCAGCTATCAACCCCATAAAGATAAAAAGAATGGTCTACTAAGCAAGCTTCCTTCC
TCTGATTTTCAAACAAAAATCTCTCATTGCTTACATTGTTCTCTCAAGCTTATTGGTCACTATTATCAATATAGGTGGTT
CTTACTATCTCCAAGGAATCTTGGATGA

Domains

Predicted by InterproScan.

• Peptidase C39 family (Peptidase_C39) (7-142)

3D structure

• AlphaFold DB: Q9ETN5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	59.89	93.333	0.559
comA	Streptococcus mitis NCTC 12261	54.891	94.359	0.518
comA	Streptococcus mitis SK321	54.348	94.359	0.513
comA	Streptococcus pneumoniae TIGR4	53.804	94.359	0.508
comA	Streptococcus pneumoniae Rx1	53.804	94.359	0.508
comA	Streptococcus pneumoniae D39	53.804	94.359	0.508
comA	Streptococcus pneumoniae R6	53.804	94.359	0.508
comA	Streptococcus gordonii str. Challis substr. CH1	52.717	94.359	0.497