Detailed information    

insolico Bioinformatically predicted

Overview

Name   comEC/celB   Type   Machinery gene
Locus tag   HMPREF0837_RS07345 Genome accession   NC_014251
Coordinates   1412320..1414560 (-) Length   746 a.a.
NCBI ID   WP_000942392.1    Uniprot ID   A0A6I3VL05
Organism   Streptococcus pneumoniae TCH8431/19A     
Function   ssDNA transport into the cell (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 1407320..1419560
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HMPREF0837_RS07310 (HMPREF0837_11526) - 1408230..1408610 (-) 381 WP_000157154.1 VOC family protein -
  HMPREF0837_RS07315 (HMPREF0837_11527) rplT 1408668..1409027 (-) 360 WP_000124836.1 50S ribosomal protein L20 -
  HMPREF0837_RS07320 (HMPREF0837_11528) rpmI 1409079..1409279 (-) 201 WP_001125943.1 50S ribosomal protein L35 -
  HMPREF0837_RS07325 (HMPREF0837_11529) infC 1409312..1409842 (-) 531 WP_000848180.1 translation initiation factor IF-3 -
  HMPREF0837_RS07330 (HMPREF0837_11531) - 1410149..1411330 (-) 1182 WP_000655951.1 membrane protein -
  HMPREF0837_RS07335 (HMPREF0837_11532) - 1411334..1411921 (-) 588 WP_000939884.1 ATP-binding cassette domain-containing protein -
  HMPREF0837_RS07340 (HMPREF0837_11533) - 1411954..1412178 (-) 225 WP_000583432.1 hypothetical protein -
  HMPREF0837_RS07345 (HMPREF0837_11534) comEC/celB 1412320..1414560 (-) 2241 WP_000942392.1 DNA internalization-related competence protein ComEC/Rec2 Machinery gene
  HMPREF0837_RS07350 (HMPREF0837_11535) comEA/celA/cilE 1414544..1415194 (-) 651 WP_000387328.1 ComEA family DNA-binding protein Machinery gene
  HMPREF0837_RS07355 (HMPREF0837_11536) - 1415262..1415831 (-) 570 WP_000443775.1 GNAT family N-acetyltransferase -
  HMPREF0837_RS13025 ald 1416008..1417119 (+) 1112 Protein_1406 alanine dehydrogenase -
  HMPREF0837_RS07375 (HMPREF0837_11540) - 1417420..1417746 (-) 327 Protein_1407 TfoX/Sxy family protein -
  HMPREF0837_RS07380 (HMPREF0837_11541) - 1417749..1418249 (-) 501 WP_000566986.1 GNAT family N-acetyltransferase -
  HMPREF0837_RS07385 (HMPREF0837_11542) - 1418442..1419410 (-) 969 WP_000658198.1 PhoH family protein -

Sequence

Protein


Download         Length: 746 a.a.        Molecular weight: 84589.24 Da        Isoelectric Point: 9.8000

>NTDB_id=37612 HMPREF0837_RS07345 WP_000942392.1 1412320..1414560(-) (comEC/celB) [Streptococcus pneumoniae TCH8431/19A]
MLQWIKNFSIPLIYLSFLLLWLYYAIFSASYLALLGFVFLLVCLFIQFPWKSAGKVLIICGIFGFWFVFQNWQQSQASQN
LADSVERVRILPDTIKVNGDSLSFRGKSNGRAFQVYYKLQSEEEKEAFQALTDLHEIGLEGKLSEPEGQRNFGGFNYQAY
LKTQGIYQTLNIKKIQSLQKIGSWDIGENLSSLRRKAVVWIKTHFPDPMRNYMTGLLLGYLNTDFEEMNELYSSLGIIHL
FALSGMQVGFFMNGFKKLLLRLGLTQEKLKWLTYPFSLIYAGLIGFSASVIRSLLQKLLAQHGVKGLDNFALTVLVLFIV
MPNFFLTAGGVLSCAYAFILTMTSKEGEGLKAVASESLVISLGILPILSFYFAEFQPWSILLTFVFSFLFDLTFLPLLSI
LFVLSFLYPVIQLNFIFEWLEGIIRLVSQVARRPLVFGQPNAWLLILLLISLALVYDLRKNIKGLTVLSLLITGLFFLTK
YPLENEITMLDVGQGESIFLRDVTGKTILIDVGGKAESYKKIEKWQEKMTTSNAQRSLIPYLKSRGVAKIDQLILTNTDK
EHVGDLLEVTKAFHVGEILVSKGSLKQKQFVVELQATQTKVRSMTVGENLPIFGSQLEVLSPRKMGDGGHDDTLVLYGKF
LDKQFLFTGNLEEKGEKDLLKHYPDLKVNVLKASQHGNKKSSSPAFLEKLKPELTLISVGKSNRMKLPHQETLTRLEGIN
SKVYRTDQQGAIRFKGWNSWKIESVR

Nucleotide


Download         Length: 2241 bp        

>NTDB_id=37612 HMPREF0837_RS07345 WP_000942392.1 1412320..1414560(-) (comEC/celB) [Streptococcus pneumoniae TCH8431/19A]
ATGTTACAGTGGATTAAGAATTTCTCTATTCCCCTAATTTACCTGAGTTTTCTATTACTTTGGCTTTATTACGCTATTTT
CTCAGCATCTTATCTTGCTTTGTTGGGCTTTGTTTTTCTGCTAGTCTGTCTCTTTATCCAATTTCCGTGGAAATCTGCTG
GTAAAGTTCTAATAATTTGCGGAATCTTTGGATTTTGGTTTGTTTTTCAAAATTGGCAACAGAGTCAAGCGAGTCAAAAT
CTGGCGGATTCTGTTGAAAGGGTACGGATTTTACCTGATACTATTAAGGTTAATGGTGATAGTCTATCCTTTCGTGGCAA
GTCTAACGGTCGTGCTTTCCAAGTCTATTATAAACTCCAGTCCGAGGAGGAGAAAGAAGCCTTTCAAGCTTTAACCGACC
TGCATGAGATAGGACTAGAAGGGAAGCTTTCGGAGCCAGAAGGGCAGAGAAATTTTGGTGGCTTTAATTACCAAGCCTAT
CTGAAGACTCAGGGAATTTACCAGACTCTCAATATCAAAAAAATCCAGTCACTTCAAAAGATTGGCAGTTGGGATATAGG
AGAAAACTTGTCCAGTTTACGTCGAAAGGCTGTGGTTTGGATTAAGACGCACTTTCCAGACCCTATGCGCAATTACATGA
CAGGACTCTTGCTGGGATATCTGAACACCGACTTTGAGGAGATGAATGAGCTTTATTCCAGTCTAGGAATTATCCACCTC
TTTGCCCTATCTGGCATGCAGGTAGGTTTTTTCATGAATGGATTTAAGAAACTTCTCTTGCGATTGGGCTTGACCCAAGA
AAAGTTGAAATGGCTGACTTATCCCTTTTCCCTTATCTATGCGGGACTAATTGGATTTTCAGCATCGGTTATTCGCAGTC
TCTTGCAAAAGCTACTGGCTCAACATGGGGTTAAGGGCTTGGATAATTTTGCCTTGACGGTGCTTGTCCTCTTTATTGTC
ATGCCAAACTTTTTCTTGACAGCAGGAGGAGTCTTGTCCTGCGCTTATGCTTTTATCCTGACCATGACCAGCAAAGAAGG
GGAGGGGCTCAAGGCTGTTGCTAGTGAAAGTCTAGTCATCTCCTTGGGCATATTGCCCATTCTATCCTTCTATTTTGCGG
AATTTCAACCTTGGTCTATCCTTTTGACCTTTGTCTTTTCCTTTCTATTTGACTTGACCTTCTTACCGCTCTTGTCTATT
TTATTTGTCCTTTCCTTTCTCTATCCAGTCATTCAGCTGAACTTTATCTTTGAATGGTTAGAGGGCATTATTCGCTTGGT
CTCGCAGGTGGCAAGGAGACCGCTTGTCTTTGGTCAACCCAACGCATGGCTTTTAATCTTATTGTTAATTTCCTTGGCTT
TGGTCTATGATTTGAGGAAAAACATTAAAGGATTAACAGTATTGAGTTTATTGATTACAGGTCTCTTTTTCCTTACCAAG
TATCCACTGGAAAATGAAATCACCATGCTGGATGTGGGGCAAGGAGAAAGTATTTTCCTACGGGATGTAACTGGGAAAAC
CATTCTCATAGATGTAGGTGGTAAGGCAGAATCTTATAAGAAAATCGAAAAATGGCAAGAAAAGATGACGACCAGCAATG
CACAGAGAAGCTTGATACCCTATCTTAAAAGTCGAGGAGTAGCTAAGATTGACCAGCTGATTTTGACAAATACGGACAAG
GAACATGTCGGAGATTTGTTAGAGGTGACCAAGGCTTTCCATGTAGGGGAGATTTTAGTATCAAAAGGCAGTTTGAAGCA
GAAGCAATTTGTGGTAGAACTACAGGCGACTCAAACAAAGGTGCGTAGTATGACAGTAGGGGAGAACTTGCCCATTTTTG
GAAGTCAGTTAGAAGTTCTATCCCCAAGGAAAATGGGAGATGGAGGACACGATGATACCCTAGTTCTGTATGGGAAATTC
TTGGATAAGCAATTTCTCTTCACGGGAAATTTGGAGGAGAAAGGAGAGAAGGACTTGCTGAAGCACTATCCAGACTTGAA
AGTAAATGTTTTGAAAGCTAGCCAACATGGCAATAAAAAATCATCAAGTCCAGCCTTTCTAGAAAAACTCAAACCAGAGC
TTACTCTTATCTCAGTTGGAAAGAGCAATCGAATGAAACTCCCCCATCAGGAAACATTGACACGACTGGAAGGTATCAAT
AGCAAAGTTTACCGAACTGACCAGCAAGGAGCTATACGGTTTAAAGGTTGGAATAGTTGGAAAATCGAAAGTGTTCGATA
G

Domains

Predicted by InterproScan.

Metallo-beta-lactamase superfamily (Lactamase_B)

(492-693)

Domain of unknown function (DUF4131) (DUF4131)

(30-177)

Competence protein (Competence)

(216-458)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A6I3VL05

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comEC/celB Streptococcus pneumoniae TIGR4

97.721

100

0.977
  comEC/celB Streptococcus pneumoniae Rx1

96.649

100

0.966
  comEC/celB Streptococcus pneumoniae D39

96.649

100

0.966
  comEC/celB Streptococcus pneumoniae R6

96.649

100

0.966
  comEC/celB Streptococcus mitis SK321

92.493

100

0.925
  comEC/celB Streptococcus mitis NCTC 12261

92.349

99.866

0.922
  comEC Lactococcus lactis subsp. cremoris KW2

44.534

99.33

0.442

Multiple sequence alignment