Detailed information
Bioinformatically predicted
Overview
| Name | vraR | Type | Regulator |
| Locus tag | SAAV_RS10030 | Genome accession | NC_013450 |
| Coordinates | 1982791..1983420 (-) | Length | 209 a.a. |
| NCBI ID | WP_000153535.1 | Uniprot ID | W8TS97 |
| Organism | Staphylococcus aureus subsp. aureus ED98 | ||
| Function | repress expression of competence genes (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 1946728..2007857 | 1982791..1983420 | within | 0 |
Gene organization within MGE regions
Location: 1946728..2007857
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| SAAV_RS09830 (SAAV_1911) | perR | 1947316..1947762 (-) | 447 | WP_000110007.1 | peroxide-responsive transcriptional repressor PerR | - |
| SAAV_RS09835 (SAAV_1912) | - | 1947859..1948809 (-) | 951 | WP_000869446.1 | phosphoglycerate dehydrogenase | - |
| SAAV_RS09840 (SAAV_1913) | bcp | 1948815..1949270 (-) | 456 | WP_000939521.1 | thioredoxin-dependent thiol peroxidase | - |
| SAAV_RS09845 (SAAV_1914) | - | 1949351..1950640 (+) | 1290 | WP_001011595.1 | glutamate-1-semialdehyde 2,1-aminomutase | - |
| SAAV_RS09850 (SAAV_1915) | - | 1950933..1952027 (+) | 1095 | WP_001236371.1 | aromatic acid exporter family protein | - |
| SAAV_RS09855 | - | 1952117..1952208 (-) | 92 | Protein_1869 | hypothetical protein | - |
| SAAV_RS09860 (SAAV_1916) | - | 1952217..1953953 (-) | 1737 | WP_000597238.1 | SAV1866 family putative multidrug efflux ABC transporter | - |
| SAAV_RS09865 (SAAV_1917) | - | 1954244..1954786 (-) | 543 | WP_000251253.1 | DUF402 domain-containing protein | - |
| SAAV_RS09870 (SAAV_1918) | mutY | 1955089..1956126 (-) | 1038 | WP_000284765.1 | A/G-specific adenine glycosylase | - |
| SAAV_RS09875 (SAAV_1919) | - | 1956278..1957255 (+) | 978 | WP_000379098.1 | metal-dependent hydrolase | - |
| SAAV_RS09885 (SAAV_1920) | - | 1957516..1958352 (-) | 837 | WP_000886462.1 | membrane protein | - |
| SAAV_RS09890 (SAAV_1921) | - | 1958361..1959878 (-) | 1518 | WP_000535834.1 | ABC transporter ATP-binding protein | - |
| SAAV_RS09895 (SAAV_1922) | - | 1959893..1960207 (-) | 315 | WP_000435806.1 | YfhH family protein | - |
| SAAV_RS09900 (SAAV_1923) | recX | 1960185..1961003 (-) | 819 | WP_001124422.1 | recombination regulator RecX | - |
| SAAV_RS09905 (SAAV_1924) | sgtB | 1961263..1962072 (-) | 810 | WP_000830380.1 | monofunctional peptidoglycan glycosyltransferase SgtB | - |
| SAAV_RS09910 (SAAV_1925) | - | 1962412..1962927 (-) | 516 | WP_000163283.1 | type 1 glutamine amidotransferase domain-containing protein | - |
| SAAV_RS09915 (SAAV_1926) | - | 1963058..1963219 (-) | 162 | WP_001005407.1 | SE1561 family protein | - |
| SAAV_RS09920 (SAAV_1927) | yfkAB | 1963443..1964594 (+) | 1152 | WP_001089621.1 | radical SAM/CxCxxxxC motif protein YfkAB | - |
| SAAV_RS09925 (SAAV_1928) | - | 1964717..1965001 (+) | 285 | WP_000134547.1 | hypothetical protein | - |
| SAAV_RS09930 (SAAV_1929) | - | 1965152..1965472 (+) | 321 | WP_000805733.1 | DUF961 family protein | - |
| SAAV_RS09935 (SAAV_1930) | - | 1965486..1965788 (+) | 303 | WP_000386891.1 | hypothetical protein | - |
| SAAV_RS09940 (SAAV_1931) | - | 1965963..1967054 (+) | 1092 | WP_000172943.1 | replication initiation factor domain-containing protein | - |
| SAAV_RS09945 (SAAV_1932) | - | 1967115..1968170 (+) | 1056 | WP_000692002.1 | conjugal transfer protein | - |
| SAAV_RS09950 (SAAV_1933) | - | 1968175..1968435 (+) | 261 | WP_000015639.1 | TcpD family membrane protein | - |
| SAAV_RS09955 (SAAV_1934) | - | 1968447..1968830 (+) | 384 | WP_000358144.1 | TcpE family conjugal transfer membrane protein | - |
| SAAV_RS09960 (SAAV_1935) | - | 1968865..1971360 (+) | 2496 | WP_001049264.1 | ATP-binding protein | - |
| SAAV_RS09965 (SAAV_1936) | - | 1971414..1972772 (+) | 1359 | WP_001251209.1 | FtsK/SpoIIIE domain-containing protein | - |
| SAAV_RS09970 (SAAV_1937) | - | 1972777..1974624 (+) | 1848 | WP_000681156.1 | membrane protein | - |
| SAAV_RS09975 (SAAV_1938) | - | 1974614..1975660 (+) | 1047 | WP_000247465.1 | CHAP domain-containing protein | - |
| SAAV_RS09980 (SAAV_1939) | - | 1975667..1976257 (+) | 591 | WP_000810443.1 | hypothetical protein | - |
| SAAV_RS09985 (SAAV_1940) | - | 1976313..1976669 (+) | 357 | WP_001255379.1 | cystatin-like fold lipoprotein | - |
| SAAV_RS15310 (SAAV_1941) | - | 1976778..1977281 (+) | 504 | WP_000746373.1 | transposase | - |
| SAAV_RS15315 (SAAV_1942) | - | 1977310..1977798 (+) | 489 | WP_142377520.1 | IS30 family transposase | - |
| SAAV_RS10000 (SAAV_1943) | - | 1978211..1978741 (-) | 531 | WP_000184383.1 | acyl-CoA thioesterase | - |
| SAAV_RS10005 (SAAV_1944) | - | 1978831..1980087 (-) | 1257 | WP_001795108.1 | aminopeptidase | - |
| SAAV_RS10010 (SAAV_1945) | - | 1980090..1980290 (-) | 201 | WP_000180460.1 | DUF1128 family protein | - |
| SAAV_RS10015 (SAAV_1946) | - | 1980437..1980901 (+) | 465 | WP_000228666.1 | low molecular weight protein-tyrosine-phosphatase | - |
| SAAV_RS10020 (SAAV_1947) | - | 1980908..1981183 (+) | 276 | WP_000428172.1 | YtxH domain-containing protein | - |
| SAAV_RS10025 (SAAV_1948) | - | 1981461..1982678 (+) | 1218 | WP_000037075.1 | YihY/virulence factor BrkB family protein | - |
| SAAV_RS10030 (SAAV_1949) | vraR | 1982791..1983420 (-) | 630 | WP_000153535.1 | two-component system response regulator VraR | Regulator |
| SAAV_RS10035 (SAAV_1950) | vraS | 1983410..1984453 (-) | 1044 | WP_001017131.1 | sensor histidine kinase | Regulator |
| SAAV_RS10040 (SAAV_1951) | liaF | 1984450..1985151 (-) | 702 | WP_000149064.1 | cell wall-active antibiotics response protein LiaF | - |
| SAAV_RS10045 (SAAV_1952) | - | 1985166..1985552 (-) | 387 | WP_001110179.1 | hypothetical protein | - |
| SAAV_RS10050 (SAAV_1953) | map | 1985769..1986527 (-) | 759 | WP_000636142.1 | type I methionyl aminopeptidase | - |
| SAAV_RS10060 (SAAV_1954) | - | 1987058..1988044 (+) | 987 | WP_000999717.1 | aromatic acid exporter family protein | - |
| SAAV_RS10065 (SAAV_1955) | - | 1988475..1988888 (-) | 414 | WP_001557448.1 | hypothetical protein | - |
| SAAV_RS10070 | - | 1988917..1989027 (-) | 111 | WP_001790257.1 | hypothetical protein | - |
| SAAV_RS10075 (SAAV_1956) | - | 1989113..1989844 (-) | 732 | WP_000544969.1 | type 1 glutamine amidotransferase | - |
| SAAV_RS10080 (SAAV_1957) | murT | 1989846..1991159 (-) | 1314 | WP_001250343.1 | lipid II isoglutaminyl synthase subunit MurT | - |
| SAAV_RS10085 (SAAV_1958) | ftnA | 1991451..1991951 (+) | 501 | WP_000949467.1 | H-type ferritin FtnA | - |
| SAAV_RS10090 (SAAV_1959) | - | 1992033..1992125 (-) | 93 | WP_001790679.1 | hypothetical protein | - |
| SAAV_RS10095 (SAAV_1960) | - | 1992340..1992894 (+) | 555 | WP_000613738.1 | 3'-5' exonuclease | - |
| SAAV_RS10100 (SAAV_1961) | dinB | 1992962..1994032 (-) | 1071 | WP_000140172.1 | DNA polymerase IV | - |
| SAAV_RS10105 (SAAV_1962) | - | 1994279..1994809 (-) | 531 | WP_000548781.1 | DUF3267 domain-containing protein | - |
| SAAV_RS10110 (SAAV_1963) | rlmD | 1994979..1996340 (-) | 1362 | WP_001147865.1 | 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD | - |
| SAAV_RS10115 (SAAV_1964) | - | 1996421..1997368 (-) | 948 | WP_001231451.1 | diacylglycerol kinase | - |
| SAAV_RS10120 | - | 1997950..1998096 (-) | 147 | WP_001789566.1 | hypothetical protein | - |
| SAAV_RS10125 (SAAV_1965) | gatB | 1998136..1999563 (-) | 1428 | WP_000545370.1 | Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB | - |
| SAAV_RS10130 (SAAV_1966) | gatA | 1999576..2001033 (-) | 1458 | WP_000027917.1 | Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA | - |
| SAAV_RS10135 (SAAV_1967) | gatC | 2001035..2001337 (-) | 303 | WP_000170162.1 | Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC | - |
| SAAV_RS10140 (SAAV_1968) | putP | 2001704..2003242 (+) | 1539 | WP_000957020.1 | sodium/proline symporter PutP | - |
| SAAV_RS10145 (SAAV_1969) | - | 2003331..2004530 (-) | 1200 | WP_000831700.1 | CamS family sex pheromone protein | - |
| SAAV_RS10150 (SAAV_1970) | ligA | 2004543..2006546 (-) | 2004 | WP_000774556.1 | NAD-dependent DNA ligase LigA | - |
Sequence
Protein
Download Length: 209 a.a. Molecular weight: 23559.32 Da Isoelectric Point: 5.3935
>NTDB_id=35605 SAAV_RS10030 WP_000153535.1 1982791..1983420(-) (vraR) [Staphylococcus aureus subsp. aureus ED98]
MTIKVLFVDDHEMVRIGISSYLSTQSDIEVVGEGASGKEAIAKAHELKPDLILMDLLMEDMDGVEATTQIKKDLPQIKVL
MLTSFIEDKEVYRALDAGVDSYILKTTSAKDIADAVRKTSRGESVFEPEVLVKMRNRMKKRAELYEMLTEREMEILLLIA
KGYSNQEIASASHITIKTVKTHVSNILSKLEVQDRTQAVIYAFQHNLIQ
MTIKVLFVDDHEMVRIGISSYLSTQSDIEVVGEGASGKEAIAKAHELKPDLILMDLLMEDMDGVEATTQIKKDLPQIKVL
MLTSFIEDKEVYRALDAGVDSYILKTTSAKDIADAVRKTSRGESVFEPEVLVKMRNRMKKRAELYEMLTEREMEILLLIA
KGYSNQEIASASHITIKTVKTHVSNILSKLEVQDRTQAVIYAFQHNLIQ
Nucleotide
Download Length: 630 bp
>NTDB_id=35605 SAAV_RS10030 WP_000153535.1 1982791..1983420(-) (vraR) [Staphylococcus aureus subsp. aureus ED98]
ATGACGATTAAAGTATTGTTTGTGGATGATCATGAAATGGTACGTATAGGAATTTCAAGTTATCTATCAACGCAAAGTGA
TATTGAAGTAGTTGGTGAAGGCGCTTCTGGTAAAGAAGCAATTGCCAAAGCCCATGAGTTGAAGCCAGATTTAATTTTAA
TGGATTTACTTATGGAAGACATGGATGGTGTAGAAGCGACGACTCAGATTAAAAAAGATTTACCGCAAATTAAAGTATTA
ATGTTAACTAGTTTTATTGAAGATAAAGAGGTATATCGTGCATTAGATGCAGGTGTCGATAGTTACATTTTAAAAACAAC
AAGTGCAAAAGATATCGCCGATGCAGTTCGTAAAACTTCTAGAGGAGAATCTGTTTTTGAACCGGAAGTTTTAGTGAAAA
TGCGTAACCGTATGAAAAAGCGCGCAGAGTTATATGAAATGCTTACAGAACGAGAAATGGAAATATTATTATTGATTGCG
AAAGGTTACTCAAATCAAGAAATTGCTAGTGCATCGCATATTACTATTAAAACGGTTAAGACACATGTGAGTAACATTTT
AAGTAAGTTAGAAGTGCAAGATAGAACACAAGCTGTCATCTATGCATTCCAACATAATTTAATTCAATAG
ATGACGATTAAAGTATTGTTTGTGGATGATCATGAAATGGTACGTATAGGAATTTCAAGTTATCTATCAACGCAAAGTGA
TATTGAAGTAGTTGGTGAAGGCGCTTCTGGTAAAGAAGCAATTGCCAAAGCCCATGAGTTGAAGCCAGATTTAATTTTAA
TGGATTTACTTATGGAAGACATGGATGGTGTAGAAGCGACGACTCAGATTAAAAAAGATTTACCGCAAATTAAAGTATTA
ATGTTAACTAGTTTTATTGAAGATAAAGAGGTATATCGTGCATTAGATGCAGGTGTCGATAGTTACATTTTAAAAACAAC
AAGTGCAAAAGATATCGCCGATGCAGTTCGTAAAACTTCTAGAGGAGAATCTGTTTTTGAACCGGAAGTTTTAGTGAAAA
TGCGTAACCGTATGAAAAAGCGCGCAGAGTTATATGAAATGCTTACAGAACGAGAAATGGAAATATTATTATTGATTGCG
AAAGGTTACTCAAATCAAGAAATTGCTAGTGCATCGCATATTACTATTAAAACGGTTAAGACACATGTGAGTAACATTTT
AAGTAAGTTAGAAGTGCAAGATAGAACACAAGCTGTCATCTATGCATTCCAACATAATTTAATTCAATAG
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| vraR | Staphylococcus aureus N315 |
100 |
100 |
1 |
| degU | Bacillus subtilis subsp. subtilis str. 168 |
34.821 |
100 |
0.373 |