Detailed information NTG0353021

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: SaO408_RS10195
• Genome accession: NZ_CP038270
• Coordinates: 1991451..1992494 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain O408 isolate B115
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1986451..1997494

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SaO408_RS10165 (SaO408_1889)	-	1986872..1988128 (-)	1257	WP_001793428.1	aminopeptidase	-
SaO408_RS10170 (SaO408_1890)	-	1988131..1988331 (-)	201	WP_000180460.1	DUF1128 family protein	-
SaO408_RS10175 (SaO408_1891)	-	1988478..1988942 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
SaO408_RS10180 (SaO408_1892)	-	1988949..1989224 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
SaO408_RS10185 (SaO408_1893)	-	1989502..1990719 (+)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
SaO408_RS10190 (SaO408_1894)	vraR	1990832..1991461 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
SaO408_RS10195 (SaO408_1895)	vraS	1991451..1992494 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
SaO408_RS10200 (SaO408_1896)	liaF	1992491..1993192 (-)	702	WP_000149070.1	cell wall-active antibiotics response protein LiaF	-
SaO408_RS10205 (SaO408_1897)	-	1993207..1993593 (-)	387	WP_001110179.1	hypothetical protein	-
SaO408_RS10210 (SaO408_1898)	map	1993810..1994568 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
SaO408_RS10220 (SaO408_1899)	-	1995095..1996081 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
SaO408_RS10225 (SaO408_1900)	-	1996270..1996683 (-)	414	WP_025174666.1	hypothetical protein	-
SaO408_RS10230	-	1996712..1996822 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=353021 SaO408_RS10195 WP_001017131.1 1991451..1992494(-) (vraS) [Staphylococcus aureus strain O408 isolate B115]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=353021 SaO408_RS10195 WP_001017131.1 1991451..1992494(-) (vraS) [Staphylococcus aureus strain O408 isolate B115]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATTTTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATT
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCGGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1