Detailed information    

insolico Bioinformatically predicted

Overview

Name   comEC/celB   Type   Machinery gene
Locus tag   EQH18_RS04475 Genome accession   NZ_CP035262
Coordinates   891018..893258 (+) Length   746 a.a.
NCBI ID   WP_000942394.1    Uniprot ID   A0A166WJ67
Organism   Streptococcus pneumoniae strain TVO_1901923     
Function   ssDNA transport into the cell (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 886018..898258
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EQH18_RS04445 (EQH18_04695) - 886364..887154 (+) 791 Protein_896 IS5 family transposase -
  EQH18_RS04450 (EQH18_04705) - 887337..887837 (+) 501 WP_000566988.1 GNAT family N-acetyltransferase -
  EQH18_RS04455 (EQH18_04710) - 887840..888166 (+) 327 Protein_898 TfoX/Sxy family protein -
  EQH18_RS04460 (EQH18_04715) ald 888471..889570 (-) 1100 Protein_899 alanine dehydrogenase -
  EQH18_RS04465 (EQH18_04720) - 889747..890316 (+) 570 WP_000443750.1 GNAT family N-acetyltransferase -
  EQH18_RS04470 (EQH18_04725) comEA/celA/cilE 890384..891034 (+) 651 WP_000387344.1 helix-hairpin-helix domain-containing protein Machinery gene
  EQH18_RS04475 (EQH18_04730) comEC/celB 891018..893258 (+) 2241 WP_000942394.1 DNA internalization-related competence protein ComEC/Rec2 Machinery gene
  EQH18_RS04480 (EQH18_04735) - 893437..893625 (+) 189 WP_001808514.1 hypothetical protein -
  EQH18_RS04485 (EQH18_04740) - 893658..894245 (+) 588 WP_000939895.1 ATP-binding cassette domain-containing protein -
  EQH18_RS04490 (EQH18_04745) - 894249..895433 (+) 1185 WP_000655960.1 ABC transporter permease -
  EQH18_RS04495 (EQH18_04750) infC 895744..896274 (+) 531 WP_000848180.1 translation initiation factor IF-3 -
  EQH18_RS04500 (EQH18_04755) rpmI 896307..896507 (+) 201 WP_001125943.1 50S ribosomal protein L35 -
  EQH18_RS04505 (EQH18_04760) rplT 896559..896918 (+) 360 WP_000124836.1 50S ribosomal protein L20 -
  EQH18_RS04510 (EQH18_04765) - 896976..897356 (+) 381 WP_000157154.1 VOC family protein -

Sequence

Protein


Download         Length: 746 a.a.        Molecular weight: 84444.00 Da        Isoelectric Point: 9.6202

>NTDB_id=338455 EQH18_RS04475 WP_000942394.1 891018..893258(+) (comEC/celB) [Streptococcus pneumoniae strain TVO_1901923]
MLQWIKNFSIPLIYLSFLLLWLYYAIFSASYLALLGFVFLLVCLFIQFPWKSAGKVLIICGIFGFWFVFQNWQQSQASQN
LADSVERVRILPDTIKVNGDSLSFRGKSNGRAFQVYYKLQSEEEKEAFQALTDLHEIGLEGKLSEPEGQRNFGGFNYQAY
LKTQGIYQTLNIKTIQSLQKIGSWDIGENLSSLRRKAVVWIKTHFPDPMGNYMTGLLLGHLDTDFEEMNELYSSLGIIHL
FALSGMQVGFFMNGFKKLLLRLGLTQEKLKWLTYPFSLIYAGLTGFSASVIRSLLQKLLAQHGVKGLDNFALTVLVLFIV
MPNFFLTAGGVLSCAYAFILTMTSKEGEGLKAVTSESLVISLGILPILSFYFAEFQPWSILLTFVFSFLFDLVFLPLLSI
LFVLSFLYPVIQLNFIFEWLEGIIRLVSQVARRPLVFGQPNAWLLILLLISLALVYDLRKNIKGLTVLSLLITGLFFLTK
YPLENEITMLDVGQGESIFLRDVTGKTILIDVGGKAESYKKIKKWQEKMTTSNAQRTLIPYLKSRGVAKIDQLILTNTDK
EHVGDLSEMTKAFHVGEILVSKDSLKQKEFVAELQATQTKVRSMIVGENLPIFGSQLEVLSPRKMGDGGHDDTLVLYGKF
LDKQFLFTGNLEEKGEKDLLKHYPDLKVNVLKASQHGNKKSSSPAFLEKLKPELTLISVGKSNRMKLPHQETLTRLEGIN
SKVYRTDQQGAIRFKGLDSWKIESVR

Nucleotide


Download         Length: 2241 bp        

>NTDB_id=338455 EQH18_RS04475 WP_000942394.1 891018..893258(+) (comEC/celB) [Streptococcus pneumoniae strain TVO_1901923]
ATGTTACAGTGGATTAAGAATTTCTCTATTCCCCTAATTTACCTGAGTTTTCTATTACTTTGGCTTTATTACGCTATTTT
CTCAGCATCTTATCTTGCTTTGTTGGGCTTTGTTTTTCTGCTAGTCTGTCTCTTTATCCAATTTCCGTGGAAATCTGCTG
GTAAAGTTCTAATAATTTGCGGAATCTTTGGATTTTGGTTTGTTTTTCAAAATTGGCAACAGAGTCAAGCGAGTCAAAAT
CTGGCGGATTCTGTTGAAAGGGTACGGATTTTGCCTGATACTATTAAGGTTAATGGTGATAGTCTATCCTTTCGTGGCAA
GTCTAACGGTCGTGCTTTCCAAGTCTATTATAAACTCCAGTCCGAGGAGGAGAAAGAAGCCTTTCAAGCTTTAACTGACC
TGCATGAGATAGGACTAGAAGGGAAGCTTTCGGAGCCAGAAGGGCAGAGAAATTTTGGTGGCTTTAATTACCAAGCCTAT
CTGAAGACTCAGGGAATTTACCAGACTCTCAATATCAAAACAATCCAGTCACTTCAAAAGATTGGCAGTTGGGATATAGG
AGAAAACTTGTCCAGTTTACGTCGAAAGGCTGTGGTTTGGATTAAGACGCACTTTCCAGACCCTATGGGCAATTACATGA
CAGGACTCTTGCTGGGACATCTGGACACCGACTTTGAGGAGATGAATGAGCTTTATTCCAGTCTAGGAATTATCCACCTC
TTTGCCCTATCTGGCATGCAGGTAGGTTTTTTCATGAATGGATTTAAGAAACTTCTCTTGCGATTGGGCTTGACCCAAGA
AAAGTTGAAATGGCTGACTTATCCCTTTTCCCTTATCTATGCGGGACTAACTGGATTTTCAGCATCGGTTATTCGCAGTC
TCTTGCAAAAGCTACTGGCTCAACATGGGGTTAAGGGCTTGGATAATTTTGCCTTGACGGTGCTTGTCCTCTTTATTGTC
ATGCCAAACTTTTTCTTGACAGCAGGAGGAGTCTTGTCCTGCGCTTATGCTTTTATCCTGACCATGACCAGCAAAGAAGG
GGAGGGGCTCAAGGCTGTTACTAGTGAAAGTCTAGTCATCTCCTTGGGCATATTGCCCATTCTATCCTTCTATTTTGCGG
AATTTCAACCTTGGTCTATCCTTTTGACCTTTGTCTTTTCCTTTCTTTTTGACTTGGTCTTCTTACCGCTCTTGTCTATC
TTATTTGTCCTTTCCTTTCTCTATCCAGTCATTCAGCTGAACTTTATCTTTGAATGGTTAGAGGGCATTATTCGCTTGGT
CTCGCAGGTGGCAAGGAGACCACTTGTCTTTGGTCAACCCAACGCATGGCTTTTAATCTTATTGTTAATTTCCTTGGCTT
TGGTCTATGATTTGAGGAAAAACATTAAAGGATTAACAGTATTGAGTTTATTGATTACAGGTCTCTTTTTCCTTACCAAG
TATCCACTGGAAAATGAAATCACCATGCTGGATGTGGGGCAAGGAGAAAGTATTTTCCTACGGGATGTAACTGGGAAAAC
CATTCTCATAGATGTAGGTGGTAAGGCAGAATCTTATAAGAAAATCAAAAAATGGCAAGAAAAGATGACGACCAGCAATG
CCCAGCGAACCTTGATTCCCTATCTCAAAAGTCGAGGAGTAGCTAAGATTGACCAGCTAATTTTGACTAACACGGACAAG
GAGCATGTTGGAGATTTGTCAGAGATGACCAAGGCTTTCCATGTAGGGGAGATTCTAGTATCAAAAGACAGTCTGAAACA
GAAGGAATTTGTGGCAGAACTACAGGCGACTCAAACAAAGGTGCGTAGTATGATAGTAGGGGAGAACTTGCCCATTTTTG
GAAGTCAGTTAGAAGTTCTATCTCCAAGGAAAATGGGAGATGGAGGACACGATGATACCCTAGTTCTGTATGGGAAATTC
TTGGATAAGCAATTTCTCTTCACGGGAAATTTGGAGGAGAAAGGAGAGAAGGACTTGCTGAAGCACTATCCAGACTTGAA
AGTAAATGTTTTGAAAGCTAGCCAACATGGCAATAAAAAATCATCAAGTCCAGCCTTTCTAGAAAAACTCAAACCAGAGC
TTACTCTTATCTCAGTTGGAAAGAGCAATCGAATGAAACTCCCCCATCAGGAAACATTGACACGACTGGAAGGTATCAAT
AGCAAAGTTTATCGAACTGACCAGCAAGGAGCTATACGTTTTAAGGGGTTGGATAGTTGGAAAATCGAAAGTGTTCGATA
G

Domains

Predicted by InterproScan.

Competence protein (Competence)

(216-458)

Domain of unknown function (DUF4131) (DUF4131)

(30-176)

Metallo-beta-lactamase superfamily (Lactamase_B)

(492-693)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A166WJ67

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comEC/celB Streptococcus pneumoniae TIGR4

100

100

1
  comEC/celB Streptococcus pneumoniae Rx1

97.587

100

0.976
  comEC/celB Streptococcus pneumoniae D39

97.587

100

0.976
  comEC/celB Streptococcus pneumoniae R6

97.587

100

0.976
  comEC/celB Streptococcus mitis SK321

92.225

100

0.922
  comEC/celB Streptococcus mitis NCTC 12261

91.812

99.866

0.917
  comEC Lactococcus lactis subsp. cremoris KW2

44.399

99.33

0.441

Multiple sequence alignment