Detailed information NTG0337961

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: EQH26_RS10920
• Genome accession: NZ_CP035254
• Coordinates: 528784..529371 (-)
• Length: 195 a.a.
• NCBI ID: WP_000205166.1
• Uniprot ID: Q9ETN5
• Organism: Streptococcus pneumoniae strain TVO_1901932
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 523784..534371

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EQH26_RS02720 (EQH26_02895)	blpC	523922..524077 (-)	156	WP_000358814.1	quorum-sensing system pheromone BlpC	-
EQH26_RS02725 (EQH26_02900)	-	524276..525622 (+)	1347	WP_001821937.1	IS1380-like element ISSpn5 family transposase	-
EQH26_RS02730 (EQH26_02905)	-	525842..527203 (-)	1362	WP_001069093.1	bacteriocin secretion accessory protein	-
EQH26_RS02735 (EQH26_02910)	comA/nlmT	527214..528890 (-)	1677	WP_307774213.1	peptide cleavage/export ABC transporter	Regulator
EQH26_RS10920	comA/nlmT	528784..529371 (-)	588	WP_000205166.1	cysteine peptidase family C39 domain-containing protein	Regulator
EQH26_RS02740 (EQH26_02915)	blpI	529653..529850 (+)	198	WP_001093259.1	bacteriocin-like peptide BlpI	-
EQH26_RS02745 (EQH26_02925)	blpJ	530317..530586 (+)	270	WP_001093248.1	bacteriocin-like peptide BlpJ	-
EQH26_RS02750 (EQH26_02930)	blpK	530655..530903 (+)	249	WP_000379965.1	bacteriocin-like peptide BlpK	-
EQH26_RS02755 (EQH26_02940)	blpU	531147..531377 (+)	231	WP_001093267.1	bacteriocin-like peptide BlpU	-
EQH26_RS02760 (EQH26_02945)	-	531380..531499 (+)	120	WP_001821949.1	PncF family bacteriocin immunity protein	-
EQH26_RS02765 (EQH26_02955)	-	531980..532338 (+)	359	Protein_554	immunity protein	-
EQH26_RS02770 (EQH26_02965)	-	532967..533350 (+)	384	WP_000877381.1	hypothetical protein	-
EQH26_RS02775 (EQH26_02970)	-	533402..534091 (+)	690	WP_000760513.1	CPBP family intramembrane glutamic endopeptidase	-
EQH26_RS02780 (EQH26_02975)	blpZ	534133..534366 (+)	234	WP_000276498.1	immunity protein BlpZ	-

Sequence

Protein

• Length: 195 a.a.
• Molecular weight: 22270.71 Da
• Isoelectric Point: 9.6188

>NTDB_id=337961 EQH26_RS10920 WP_000205166.1 528784..529371(-) (comA/nlmT) [Streptococcus pneumoniae strain TVO_1901932]
MTSYKRTFVPQIDARDCGVAALASIAKFYGSDFSLAHLRELAKTNKEGTTALGIVKAADEMGFETRPVQADKTLFDMSDV
PYPFIVHVNKEGKLQHYYVVYQTKKDYLIIGDPDPSVKITKMSKERFFYEWTGVAIFLATKPSYQPHKDKKNGLLSKLPS
SDFQTKISHCLHCSLKLIGHYYQYRWFLLSPRNLG

Nucleotide

• Length: 588 bp

>NTDB_id=337961 EQH26_RS10920 WP_000205166.1 528784..529371(-) (comA/nlmT) [Streptococcus pneumoniae strain TVO_1901932]
ATGACTTCTTATAAACGTACATTTGTTCCTCAAATAGATGCGAGAGACTGTGGTGTCGCTGCCTTAGCCTCGATTGCTAA
ATTCTATGGTTCAGATTTTTCTCTAGCTCACTTGAGAGAACTTGCAAAGACCAATAAAGAAGGGACGACTGCTCTTGGCA
TTGTAAAAGCCGCTGATGAAATGGGCTTTGAAACAAGACCTGTTCAAGCAGATAAAACGCTCTTTGACATGAGTGATGTC
CCCTATCCATTTATCGTTCACGTTAACAAAGAAGGAAAACTCCAACATTACTATGTTGTCTATCAAACAAAGAAAGACTA
TCTGATTATTGGTGATCCTGACCCTTCTGTAAAAATCACTAAAATGTCAAAAGAACGCTTTTTCTATGAATGGACTGGAG
TAGCTATTTTTCTAGCTACCAAACCCAGCTATCAACCCCATAAAGATAAAAAGAATGGTCTACTAAGCAAGCTTCCTTCC
TCTGATTTTCAAACAAAAATCTCTCATTGCTTACATTGTTCTCTCAAGCTTATTGGTCACTATTATCAATATAGGTGGTT
CTTACTATCTCCAAGGAATCTTGGATGA

Domains

Predicted by InterproScan.

• Peptidase C39 family (Peptidase_C39) (7-142)

3D structure

• AlphaFold DB: Q9ETN5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	59.89	93.333	0.559
comA	Streptococcus mitis NCTC 12261	54.891	94.359	0.518
comA	Streptococcus mitis SK321	54.348	94.359	0.513
comA	Streptococcus pneumoniae TIGR4	53.804	94.359	0.508
comA	Streptococcus pneumoniae Rx1	53.804	94.359	0.508
comA	Streptococcus pneumoniae D39	53.804	94.359	0.508
comA	Streptococcus pneumoniae R6	53.804	94.359	0.508
comA	Streptococcus gordonii str. Challis substr. CH1	52.717	94.359	0.497