Detailed information    

insolico Bioinformatically predicted

Overview

Name   comEC/celB   Type   Machinery gene
Locus tag   EQH26_RS04635 Genome accession   NZ_CP035254
Coordinates   915016..917259 (+) Length   747 a.a.
NCBI ID   WP_000942400.1    Uniprot ID   A0A4J1URN1
Organism   Streptococcus pneumoniae strain TVO_1901932     
Function   ssDNA transport into the cell (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 910016..922259
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EQH26_RS04605 (EQH26_04900) - 910167..911135 (+) 969 WP_000658183.1 PhoH family protein -
  EQH26_RS04610 (EQH26_04910) - 911328..911828 (+) 501 WP_000566988.1 GNAT family N-acetyltransferase -
  EQH26_RS04615 (EQH26_04915) - 911831..912157 (+) 327 Protein_925 TfoX/Sxy family protein -
  EQH26_RS04620 ald 912458..913568 (-) 1111 Protein_926 alanine dehydrogenase -
  EQH26_RS04625 (EQH26_04935) - 913745..914314 (+) 570 WP_000443770.1 GNAT family N-acetyltransferase -
  EQH26_RS04630 (EQH26_04940) comEA/celA/cilE 914382..915032 (+) 651 WP_000387359.1 ComEA family DNA-binding protein Machinery gene
  EQH26_RS04635 (EQH26_04945) comEC/celB 915016..917259 (+) 2244 WP_000942400.1 DNA internalization-related competence protein ComEC/Rec2 Machinery gene
  EQH26_RS04640 (EQH26_04950) - 917438..917626 (+) 189 WP_001812421.1 hypothetical protein -
  EQH26_RS04645 (EQH26_04955) - 917659..918246 (+) 588 WP_000939895.1 ATP-binding cassette domain-containing protein -
  EQH26_RS04650 (EQH26_04960) - 918250..919431 (+) 1182 WP_000655932.1 membrane protein -
  EQH26_RS04655 (EQH26_04965) infC 919738..920268 (+) 531 WP_000848180.1 translation initiation factor IF-3 -
  EQH26_RS04660 (EQH26_04970) rpmI 920301..920501 (+) 201 WP_001125943.1 50S ribosomal protein L35 -
  EQH26_RS04665 (EQH26_04975) rplT 920553..920912 (+) 360 WP_000124836.1 50S ribosomal protein L20 -
  EQH26_RS04670 (EQH26_04980) - 920970..921350 (+) 381 WP_000157139.1 VOC family protein -

Sequence

Protein


Download         Length: 747 a.a.        Molecular weight: 84588.04 Da        Isoelectric Point: 9.5181

>NTDB_id=337906 EQH26_RS04635 WP_000942400.1 915016..917259(+) (comEC/celB) [Streptococcus pneumoniae strain TVO_1901932]
MLQWIKNFSIPLIYLSFLLLWLYYAIFSASYLALLGFVFLLVCLFIQFPWKSAGKVLIICGIFGFWFVFQNWQQSQASQN
LADSVERVRILPDTIKVNGDSLSFRGKSNGRAFQVYYKLQSEEEKEAFQALTDLHEIGLEGKLSEPEGQRNFGGFNYQAY
LKTQGIYQTLNIKTIQSLQKIGSWDIGENLSSLRRKAVVWIKTHFPDPMRNYMTGLLLGHLDTDFEEMNELYSSLGIIHL
FALSGMQVGFFMNGFKKLLLRLGLTQEKLKWLTYPFSLIYAGLTGFSASVIRSLLQKLLAQHGVKGLDNFALTVLVLFIV
MPNFFLTAGGVLSCAYAFILTMTSKEGEGLKAVTSESLVISLGILPILSFYFAEFQPWSILLTFVFSFLFDLTFLPLLSI
LFVLSFLYPVIQLNFIFEWLEGIIRLVSQVTSRPLVFGQPNAWFLILLLISLALVYDLRKNIKKLTVLCLLITGLFLLTK
HPLENEITMLDVGQGESIFLRDVTGKTILIDVGGKAESYKKIEKWQEKMTTSNAQRTLIPYLKSRGVAKIDQLILTNTDK
ENVGDLSEVTKAFHVGEILVSKDSLKQKEFVAELQATQTKVRSMTVGENLPIFGSQLEVLSPRKMGDGGHDDTLVLYGKF
LDKQFLFTGNLEEKGEKDLLKHYPDLKVNVLKASQHGNKKSSSPAFLEKLKPELTLISVGKSNRMKLPHQETLTRLEGIN
SSKVYRTDQQGAIRFKGLDSWKIESVR

Nucleotide


Download         Length: 2244 bp        

>NTDB_id=337906 EQH26_RS04635 WP_000942400.1 915016..917259(+) (comEC/celB) [Streptococcus pneumoniae strain TVO_1901932]
ATGTTACAGTGGATTAAGAATTTCTCTATTCCCCTAATTTACCTGAGTTTTCTATTACTTTGGCTTTATTACGCTATTTT
CTCAGCATCTTATCTTGCTTTGTTGGGCTTTGTTTTTCTGCTAGTCTGTCTCTTTATCCAATTTCCGTGGAAATCTGCTG
GTAAAGTTCTAATAATTTGCGGAATCTTTGGATTTTGGTTTGTTTTTCAAAATTGGCAACAGAGTCAAGCGAGTCAAAAT
CTGGCGGATTCTGTTGAAAGGGTACGGATTTTGCCTGATACTATTAAGGTTAATGGTGATAGTCTATCCTTTCGTGGCAA
GTCTAACGGTCGTGCTTTCCAAGTCTATTATAAACTCCAGTCCGAGGAGGAGAAAGAAGCCTTTCAAGCTTTAACCGACC
TGCATGAGATAGGACTAGAAGGGAAGCTTTCGGAGCCAGAAGGGCAGAGAAATTTTGGTGGCTTTAATTACCAAGCCTAT
CTGAAGACTCAGGGAATTTACCAGACTCTCAATATCAAAACAATCCAGTCACTTCAAAAGATTGGCAGTTGGGATATAGG
AGAAAACTTGTCCAGTTTACGTCGAAAGGCTGTGGTTTGGATTAAGACGCACTTTCCAGACCCTATGCGCAATTACATGA
CAGGACTCTTGCTGGGACATCTGGACACCGACTTTGAGGAGATGAATGAGCTTTATTCCAGTCTAGGAATTATCCACCTC
TTTGCCCTATCTGGTATGCAGGTAGGTTTTTTCATGAATGGATTTAAGAAACTTCTCTTGCGATTGGGCTTGACCCAAGA
AAAGTTGAAATGGCTGACTTATCCCTTTTCCCTTATCTATGCGGGACTAACTGGATTTTCAGCATCGGTTATTCGCAGTC
TCTTGCAAAAGCTACTGGCTCAACATGGGGTTAAGGGCTTGGATAATTTTGCCTTGACGGTGCTTGTCCTCTTTATTGTC
ATGCCAAACTTTTTCTTGACAGCAGGAGGAGTCTTGTCCTGCGCTTATGCTTTTATCCTGACCATGACCAGCAAAGAAGG
GGAGGGGCTCAAGGCTGTTACTAGTGAAAGTCTAGTCATCTCCTTGGGCATATTGCCCATTCTATCCTTCTATTTTGCGG
AATTTCAACCTTGGTCTATCCTTTTGACCTTTGTCTTTTCCTTTCTATTTGACTTGACCTTCTTACCGCTCTTGTCTATT
TTATTTGTCCTTTCCTTTCTCTATCCAGTCATTCAGCTGAACTTTATCTTTGAATGGTTGGAGGGCATTATTCGCTTGGT
GTCACAGGTGACAAGTAGACCTCTGGTCTTTGGACAACCCAATGCATGGTTTTTAATCCTATTGTTAATTTCCTTGGCTT
TGGTCTATGATTTGAGAAAAAACATTAAAAAGCTAACGGTATTGTGCTTATTGATTACAGGGCTCTTTCTCCTGACCAAG
CATCCACTGGAAAATGAAATCACCATGCTGGATGTGGGGCAAGGAGAAAGTATTTTCCTACGGGATGTAACTGGGAAAAC
CATTCTCATAGATGTAGGTGGTAAGGCAGAATCTTATAAGAAAATCGAAAAATGGCAAGAAAAGATGACGACCAGCAATG
CCCAGCGAACCTTGATTCCCTATCTCAAAAGTCGAGGAGTAGCTAAGATTGACCAGCTAATTTTGACTAACACGGACAAG
GAGAATGTTGGAGATTTGTCAGAGGTGACCAAGGCTTTCCATGTAGGGGAGATTCTAGTATCAAAAGACAGTCTGAAACA
GAAGGAATTTGTGGCAGAACTACAGGCGACTCAAACAAAGGTGCGTAGTATGACAGTAGGGGAGAACTTGCCCATTTTTG
GAAGTCAGTTAGAAGTTCTATCTCCAAGGAAAATGGGAGATGGAGGACACGATGATACCCTAGTTCTGTATGGGAAATTC
TTGGATAAGCAATTTCTCTTCACGGGAAATTTGGAGGAGAAAGGAGAGAAGGACTTGCTGAAGCACTATCCAGACTTGAA
AGTAAATGTTTTGAAAGCTAGCCAACATGGCAATAAAAAATCATCAAGTCCAGCCTTTCTAGAAAAACTCAAACCAGAGC
TTACTCTTATCTCAGTTGGAAAGAGCAATCGAATGAAACTCCCCCATCAGGAAACATTGACACGACTGGAAGGTATCAAT
AGCAGCAAAGTTTATCGAACTGACCAGCAAGGAGCTATACGTTTTAAGGGGTTGGATAGTTGGAAAATCGAAAGTGTTCG
ATAG

Domains

Predicted by InterproScan.

Domain of unknown function (DUF4131) (DUF4131)

(30-176)

Metallo-beta-lactamase superfamily (Lactamase_B)

(492-693)

Competence protein (Competence)

(216-458)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A4J1URN1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comEC/celB Streptococcus pneumoniae TIGR4

98.126

100

0.981
  comEC/celB Streptococcus pneumoniae D39

97.858

100

0.979
  comEC/celB Streptococcus pneumoniae R6

97.858

100

0.979
  comEC/celB Streptococcus pneumoniae Rx1

97.858

100

0.979
  comEC/celB Streptococcus mitis NCTC 12261

91.957

99.866

0.918
  comEC/celB Streptococcus mitis SK321

91.7

100

0.917
  comEC Lactococcus lactis subsp. cremoris KW2

44.07

99.331

0.438

Multiple sequence alignment