Detailed information NTG0031373

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: SEZ_RS04755
• Genome accession: NC_011134
• Coordinates: 1004615..1005352 (+)
• Length: 245 a.a.
• NCBI ID: WP_012515591.1
• Uniprot ID: B4U2V5
• Organism: Streptococcus equi subsp. zooepidemicus MGCS10565
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 999615..1010352

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SEZ_RS04725 (Sez_0958)	-	1000065..1000970 (-)	906	WP_012515585.1	diacylglycerol kinase family protein	-
SEZ_RS04730 (Sez_0959)	-	1001080..1001730 (-)	651	WP_012515586.1	hemolysin III family protein	-
SEZ_RS04735 (Sez_0960)	-	1001714..1002169 (-)	456	WP_012515587.1	DUF1836 domain-containing protein	-
SEZ_RS04740 (Sez_0961)	-	1002429..1003184 (+)	756	WP_012515588.1	class I SAM-dependent methyltransferase	-
SEZ_RS04745 (Sez_0962)	-	1003212..1003550 (+)	339	WP_012515589.1	cupin domain-containing protein	-
SEZ_RS04750 (Sez_0963)	-	1003552..1003857 (+)	306	WP_012515590.1	hypothetical protein	-
SEZ_RS04755 (Sez_0964)	comE/blpR	1004615..1005352 (+)	738	WP_012515591.1	response regulator transcription factor	Regulator
SEZ_RS04760 (Sez_0965)	-	1005725..1005925 (+)	201	WP_012515592.1	hypothetical protein	-
SEZ_RS04765 (Sez_0966)	-	1005992..1006846 (+)	855	WP_012515593.1	ABC transporter ATP-binding protein	-
SEZ_RS09955 (Sez_0967)	-	1006852..1007331 (+)	480	WP_012515594.1	hypothetical protein	-
SEZ_RS09960 (Sez_0968)	-	1007319..1008014 (+)	696	WP_228361775.1	ABC transporter permease subunit	-
SEZ_RS04775 (Sez_0969)	-	1008276..1008506 (+)	231	WP_012515596.1	Blp family class II bacteriocin	-
SEZ_RS04780 (Sez_0970)	-	1009299..1010150 (+)	852	WP_012515597.1	thioredoxin family protein	-

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28894.28 Da
• Isoelectric Point: 7.8796

>NTDB_id=31373 SEZ_RS04755 WP_012515591.1 1004615..1005352(+) (comE/blpR) [Streptococcus equi subsp. zooepidemicus MGCS10565]
MNIFILEDDLGQQFRLEMKIQEILDKHHWTCDRFEVYGKPYQLLANVTERGRHQLFFLDSQIRNDEKKGLAVAREIRKRD
PYALIVFVTTHSELMPVSFRYQVSALDFIDKELSMKHFSDRIERAIIYAYEEQENVTSEGLFIFVTAKAQVQVPFSSLLF
IETSSTPHKLILHSQNERIEFYGFLSEVLKQDSRLVQCHRSYVINPYNVSFLDRDKRLLYFKNGQSCMVSRLKMKALEAS
IKALH

Nucleotide

• Length: 738 bp

>NTDB_id=31373 SEZ_RS04755 WP_012515591.1 1004615..1005352(+) (comE/blpR) [Streptococcus equi subsp. zooepidemicus MGCS10565]
ATGAATATTTTTATTCTCGAAGATGATCTAGGCCAACAGTTTAGGCTTGAGATGAAGATTCAAGAGATATTGGATAAGCA
TCACTGGACTTGTGATCGTTTTGAAGTTTATGGAAAGCCCTACCAGCTTCTGGCAAATGTTACAGAGAGAGGCAGGCATC
AGCTTTTCTTTCTCGATAGTCAAATTCGAAATGATGAGAAAAAGGGCTTAGCTGTTGCTCGTGAGATCAGAAAGCGTGAC
CCTTATGCCCTCATTGTTTTTGTCACCACACATTCTGAGCTTATGCCAGTTTCTTTTCGTTATCAGGTGTCTGCTCTAGA
TTTTATCGATAAGGAATTGTCAATGAAACATTTCTCAGATAGGATTGAAAGAGCCATTATATATGCTTATGAAGAGCAAG
AAAATGTAACCTCAGAGGGCTTATTTATTTTTGTAACGGCTAAGGCTCAGGTGCAGGTTCCTTTTTCAAGCCTATTGTTC
ATTGAGACCTCTAGTACTCCTCACAAGTTGATTTTGCATTCTCAAAACGAGCGAATAGAATTTTATGGCTTTCTTTCAGA
GGTTCTTAAGCAAGATTCCAGACTAGTCCAATGTCATCGTTCTTATGTTATCAATCCTTACAATGTTTCGTTTCTTGATC
GTGATAAGCGTTTACTCTATTTCAAGAATGGGCAGTCTTGCATGGTTTCAAGACTAAAAATGAAAGCACTTGAGGCGTCT
ATTAAGGCTTTGCATTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-240)

• Response regulator receiver domain (Response_reg) (18-122)

3D structure

• AlphaFold DB: B4U2V5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	53.719	98.776	0.531
comE/comE1	Streptococcus equinus JB1	45.455	98.776	0.449
comE/comE2	Streptococcus equinus JB1	36.885	99.592	0.367