Detailed information NTG0310903

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: D0Z58_RS06590
• Genome accession: NZ_CP031738
• Coordinates: 1257474..1258511 (-)
• Length: 345 a.a.
• NCBI ID: WP_002989068.1
• Uniprot ID: Q1JKX2
• Organism: Streptococcus pyogenes strain SP1336
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1252474..1263511

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
D0Z58_RS06565 (D0Z58_06560)	-	1252478..1253005 (-)	528	WP_002983837.1	Dps family protein	-
D0Z58_RS06570 (D0Z58_06565)	-	1253233..1253859 (+)	627	WP_002989076.1	A24 family peptidase	-
D0Z58_RS06575 (D0Z58_06570)	rlmN	1253941..1255020 (-)	1080	WP_002989074.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
D0Z58_RS06580 (D0Z58_06575)	-	1255024..1255644 (-)	621	WP_032461520.1	YutD family protein	-
D0Z58_RS06585 (D0Z58_06580)	-	1256092..1257069 (-)	978	WP_002989070.1	LacI family DNA-binding transcriptional regulator	-
D0Z58_RS06590 (D0Z58_06585)	sepM	1257474..1258511 (-)	1038	WP_002989068.1	SepM family pheromone-processing serine protease	Regulator
D0Z58_RS06595 (D0Z58_06590)	coaD	1258498..1258989 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
D0Z58_RS06600 (D0Z58_06595)	rsmD	1258979..1259518 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
D0Z58_RS06605 (D0Z58_06600)	asnA	1259641..1260633 (-)	993	WP_002983817.1	aspartate--ammonia ligase	-
D0Z58_RS06610 (D0Z58_06605)	arcC	1260947..1261897 (-)	951	WP_002989065.1	carbamate kinase	-
D0Z58_RS06615 (D0Z58_06610)	-	1261917..1263248 (-)	1332	WP_002989063.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37527.17 Da
• Isoelectric Point: 9.5788

>NTDB_id=310903 D0Z58_RS06590 WP_002989068.1 1257474..1258511(-) (sepM) [Streptococcus pyogenes strain SP1336]
MKRLNKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=310903 D0Z58_RS06590 WP_002989068.1 1257474..1258511(-) (sepM) [Streptococcus pyogenes strain SP1336]
ATGAAAAGACTTAACAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAG

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: Q1JKX2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	68.986	100	0.69