Detailed information NTG0290238

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: CSC49_RS13710
• Genome accession: NZ_CP029084
• Coordinates: 2661156..2662199 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain AR464
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2656156..2667199

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
CSC49_RS13680 (CSC49_2550)	-	2656577..2657824 (-)	1248	WP_000656302.1	aminopeptidase	-
CSC49_RS13685 (CSC49_2551)	-	2657836..2658036 (-)	201	WP_000180459.1	DUF1128 family protein	-
CSC49_RS13690 (CSC49_2552)	-	2658183..2658647 (+)	465	WP_000228668.1	low molecular weight protein-tyrosine-phosphatase	-
CSC49_RS13695 (CSC49_2553)	-	2658654..2658929 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
CSC49_RS13700 (CSC49_2554)	-	2659207..2660424 (+)	1218	WP_000037083.1	YihY/virulence factor BrkB family protein	-
CSC49_RS13705 (CSC49_2555)	vraR	2660537..2661166 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
CSC49_RS13710 (CSC49_2556)	vraS	2661156..2662199 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
CSC49_RS13715 (CSC49_2557)	liaF	2662196..2662897 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
CSC49_RS13720 (CSC49_2558)	-	2662912..2663298 (-)	387	WP_001110184.1	hypothetical protein	-
CSC49_RS13725 (CSC49_2559)	map	2663515..2664273 (-)	759	WP_000636137.1	type I methionyl aminopeptidase	-
CSC49_RS13735 (CSC49_2561)	-	2664804..2665790 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
CSC49_RS13740 (CSC49_2562)	-	2665968..2666381 (-)	414	WP_001622129.1	hypothetical protein	-
CSC49_RS13745	-	2666410..2666519 (-)	110	Protein_2540	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=290238 CSC49_RS13710 WP_001017131.1 2661156..2662199(-) (vraS) [Staphylococcus aureus strain AR464]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=290238 CSC49_RS13710 WP_001017131.1 2661156..2662199(-) (vraS) [Staphylococcus aureus strain AR464]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTACCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTCGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1