Detailed information    

insolico Bioinformatically predicted

Overview

Name   agrA   Type   Regulator
Locus tag   CAC37_RS09765 Genome accession   NZ_CP021178
Coordinates   1990358..1991074 (+) Length   238 a.a.
NCBI ID   WP_000688492.1    Uniprot ID   A0A7U7IEW1
Organism   Staphylococcus aureus subsp. aureus ST398 strain 2012-3     
Function   promote expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 1985358..1996074
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  CAC37_RS09735 (CAC37_10130) - 1985625..1986251 (+) 627 WP_000522384.1 nitroreductase family protein -
  CAC37_RS09740 (CAC37_10135) - 1986559..1987344 (+) 786 WP_000867947.1 carbon-nitrogen family hydrolase -
  CAC37_RS13445 hld 1987946..1988026 (-) 81 WP_000046022.1 delta-hemolysin -
  CAC37_RS09750 (CAC37_10145) agrB 1988316..1988885 (+) 570 WP_001105708.1 accessory gene regulator AgrB -
  CAC37_RS09755 (CAC37_10150) agrD 1988882..1989022 (+) 141 WP_001093929.1 cyclic lactone autoinducer peptide AgrD -
  CAC37_RS09760 (CAC37_10155) agrC 1989047..1990339 (+) 1293 WP_001825886.1 quorum-sensing sensor histidine kinase AgrC -
  CAC37_RS09765 (CAC37_10160) agrA 1990358..1991074 (+) 717 WP_000688492.1 quorum-sensing response regulator AgrA Regulator
  CAC37_RS09770 (CAC37_10165) - 1991448..1992407 (-) 960 WP_001253294.1 carbohydrate kinase family protein -
  CAC37_RS09775 (CAC37_10170) - 1992404..1993888 (-) 1485 WP_000141407.1 sucrose-6-phosphate hydrolase -
  CAC37_RS09780 (CAC37_10175) - 1994037..1994987 (-) 951 WP_000790325.1 LacI family DNA-binding transcriptional regulator -

Sequence

Protein


Download         Length: 238 a.a.        Molecular weight: 27905.90 Da        Isoelectric Point: 6.0927

>NTDB_id=228961 CAC37_RS09765 WP_000688492.1 1990358..1991074(+) (agrA) [Staphylococcus aureus subsp. aureus ST398 strain 2012-3]
MKIFICEDDPKQRENMVTIIKNYIMIEEKPMEIALATDNPYEVLEQAKNMNDIGCYFLDIQLSTDINGIKLGSEIRKHDP
VGNIIFVTSHSELTYLTFVYKVAAMDFIFKDDPAELRTRIIDCLETAHTRLQLLSKDNSVETIELKRGSNSVYVQYDDIM
FFESSTKSHRLIAHLDNRQIEFYGNLKELSQLDDRFFRCHNSFVVNRHNIESIDSKERIVYFKNKEHCYASVRNVKKI

Nucleotide


Download         Length: 717 bp        

>NTDB_id=228961 CAC37_RS09765 WP_000688492.1 1990358..1991074(+) (agrA) [Staphylococcus aureus subsp. aureus ST398 strain 2012-3]
ATGAAAATTTTCATTTGCGAAGACGATCCAAAACAAAGAGAAAACATGGTTACCATTATTAAAAATTATATAATGATAGA
AGAAAAGCCTATGGAAATTGCCCTCGCAACTGATAATCCTTATGAGGTGCTTGAGCAAGCTAAAAATATGAATGACATAG
GCTGTTACTTTTTAGATATTCAACTTTCAACTGATATTAATGGTATCAAATTAGGCAGTGAAATTCGTAAGCATGACCCA
GTTGGTAACATTATTTTCGTTACGAGTCACAGTGAACTTACGTATTTAACATTTGTCTACAAAGTTGCAGCGATGGATTT
TATTTTTAAAGATGATCCAGCAGAATTAAGAACTCGAATTATAGATTGTTTAGAAACTGCACATACACGCTTACAATTAT
TATCAAAAGATAATAGCGTTGAAACGATTGAGTTAAAACGTGGCAGTAATTCAGTGTATGTTCAATATGATGATATTATG
TTTTTTGAATCATCAACAAAATCTCACAGACTCATTGCCCATTTAGATAACCGTCAAATTGAATTTTATGGTAATTTAAA
AGAACTGAGTCAATTAGATGATCGTTTCTTCAGATGTCATAATAGCTTTGTCGTCAATCGTCATAATATCGAATCTATTG
ATTCGAAAGAGCGTATTGTTTATTTTAAAAATAAAGAACACTGCTATGCATCGGTGAGAAACGTTAAAAAAATATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(3-120)

LytTr DNA-binding domain (LytTR)

(151-237)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A7U7IEW1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  agrA Staphylococcus aureus N315

100

100

1

Multiple sequence alignment