Detailed information NTG0021332

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: SAS_RS09810
• Genome accession: NC_002953
• Coordinates: 1967180..1968223 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus subsp. aureus MSSA476
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1962180..1973223

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SAS_RS09780 (SAS1801)	-	1962608..1963864 (-)	1257	WP_078055712.1	aminopeptidase	-
SAS_RS09785 (SAS1802)	-	1963867..1964067 (-)	201	WP_000180460.1	DUF1128 family protein	-
SAS_RS09790 (SAS1803)	-	1964214..1964678 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
SAS_RS09795 (SAS1804)	-	1964685..1964960 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
SAS_RS09800 (SAS1805)	-	1965238..1966449 (+)	1212	WP_000037091.1	YihY/virulence factor BrkB family protein	-
SAS_RS09805 (SAS1806)	vraR	1966561..1967190 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
SAS_RS09810 (SAS1807)	vraS	1967180..1968223 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
SAS_RS09815 (SAS1808)	liaF	1968220..1968921 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
SAS_RS09820 (SAS1809)	-	1968936..1969322 (-)	387	WP_001110179.1	hypothetical protein	-
SAS_RS09825 (SAS1810)	map	1969539..1970297 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
SAS_RS09835 (SAS1811)	-	1970828..1971814 (+)	987	WP_000999713.1	FUSC family protein	-
SAS_RS09840 (SAS1812)	-	1972304..1972717 (-)	414	WP_001837236.1	hypothetical protein	-
SAS_RS09845	-	1972746..1972857 (-)	112	Protein_1861	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=21332 SAS_RS09810 WP_001017131.1 1967180..1968223(-) (vraS) [Staphylococcus aureus subsp. aureus MSSA476]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=21332 SAS_RS09810 WP_001017131.1 1967180..1968223(-) (vraS) [Staphylococcus aureus subsp. aureus MSSA476]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCGATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1