Detailed information NTG0193226

Bioinformatically predicted

Overview

• Name: letS
• Type: Regulator
• Locus tag: BE845_RS13900
• Genome accession: NZ_CP016874
• Coordinates: 3138167..3140899 (-)
• Length: 910 a.a.
• NCBI ID: WP_011215874.1
• Uniprot ID: Q5WVD9
• Organism: Legionella pneumophila subsp. pneumophila strain FFI329
• Function: regulate competence development (predicted from homology) Competence regulation

Genomic Context

Location: 3133167..3145899

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
BE845_RS13875 (BE845_13875)	-	3133689..3135110 (-)	1422	WP_011215879.1	APC family permease	-
BE845_RS13880 (BE845_13880)	-	3135185..3135502 (-)	318	WP_011215878.1	BolA family protein	-
BE845_RS13885 (BE845_13885)	pilA2	3135804..3136217 (+)	414	WP_011215877.1	pilin	Machinery gene
BE845_RS13890 (BE845_13890)	pilA2	3136415..3136828 (+)	414	WP_011215876.1	pilin	Machinery gene
BE845_RS13895 (BE845_13895)	-	3136825..3138069 (-)	1245	WP_011215875.1	6-phosphofructokinase	-
BE845_RS13900 (BE845_13900)	letS	3138167..3140899 (-)	2733	WP_011215874.1	two-component system sensor histidine kinase LetS	Regulator
BE845_RS13905 (BE845_13905)	gltX	3140998..3142410 (+)	1413	WP_011215873.1	glutamate--tRNA ligase	-
BE845_RS13910 (BE845_13910)	-	3142653..3143915 (+)	1263	WP_011215872.1	serine hydrolase domain-containing protein	-
BE845_RS13915 (BE845_13915)	-	3143956..3144951 (+)	996	WP_011215871.1	hypothetical protein	-
BE845_RS13920 (BE845_13920)	gstA	3145148..3145753 (+)	606	WP_011215870.1	glutathione transferase GstA	-

Sequence

Protein

• Length: 910 a.a.
• Molecular weight: 102912.46 Da
• Isoelectric Point: 7.7914

>NTDB_id=193226 BE845_RS13900 WP_011215874.1 3138167..3140899(-) (letS) [Legionella pneumophila subsp. pneumophila strain FFI329]
MLKSIGIKYQLRITTLIPAFLVALLFAFFYNGLFGKDLKQHMSRLGEAYIRQLLPAAQYAMLRNDYRTLQGLINASTINP
EVKALAFYNADGRLIAYRGGKHSIHKPFNPPDYTGDYIESKQINPFTINFIAPITIPKFNLYSSTEFKEPSTPKIFQADD
ILGWLSIDIDTQSLLIKRYQMLIVTIFITLFGLLMGLTIHYFLSKRIYMPIARLRRSMKQILSNEFETEIRVSSPGELGI
IEKGCAHLQRQYLNTVRDLNHHIEIATADLQQSLELLEEKNIELSLEKKKTEEKSRQKSEFIANMSHEIRTPMNGVIGFT
NVLLESKLDPLQLDYVKTIKSSAQDLLSIINAILDFSKIDAGKLNLDCIPLDVRGCIDEVLSLASPNAHKKVIDLIPITD
INVPKMVLGDPLRIKQIISNLVTNAVKFTDHGYVLIRTKIEQETDKDYTLLFAITDTGIGISPEDQTKLFTAFNQADTSI
TRRYGGSGLGLVICKKLCEEMHGRISLTSEINKGSTFSARIKVEKLVAYEIEKNQTHRFAHLKIICFDDNPLHLEAIGNG
LGFWGIEAIRVDSFNKLSRTLTKHKDCKIAFINVNQGCERQAAELIAKHKQIPFVLISKWPINDFAALGARGFLYKPISI
QKLQDLIESIANENQTEKNTNQELDTLREQLRFLHPEILIAEDNPVNKMLLTSLLNNNANITTVDDGEMAVTACEDKKFD
MILLDLHMPKLNGLEAAKMIRQKSLMNKHSPIVLITASSSDLSSIDMKKSGVDFCFQKPIDEKQLLIQILRIVDKIKHAA
IDWQLCVQKVSGNQALAEEFLAKFIEELYKNREEFIGLMHQKNVKGLADLAHKLHGACCFCGVPILQKRVAQLEKLARRT
ANADNLSEAFTDLIQSIDAVISEYENQYSQ

Nucleotide

• Length: 2733 bp

>NTDB_id=193226 BE845_RS13900 WP_011215874.1 3138167..3140899(-) (letS) [Legionella pneumophila subsp. pneumophila strain FFI329]
ATGTTGAAAAGTATTGGTATTAAATATCAGCTAAGAATCACTACTCTTATTCCTGCCTTTTTAGTCGCCTTGCTTTTTGC
TTTTTTTTATAACGGCCTATTTGGTAAAGATCTAAAGCAGCATATGTCCAGACTGGGTGAAGCCTATATCAGGCAATTAC
TTCCAGCAGCCCAGTATGCCATGCTTCGCAATGATTACCGTACATTGCAGGGTTTAATCAATGCCTCAACCATTAACCCG
GAGGTAAAAGCTTTGGCATTTTATAATGCCGATGGCCGATTAATTGCTTATCGTGGCGGCAAGCACTCTATCCATAAACC
ATTCAATCCACCTGACTATACAGGTGACTACATTGAAAGTAAGCAAATTAATCCATTCACCATTAATTTTATAGCGCCGA
TTACTATCCCAAAGTTCAATTTGTACTCAAGCACAGAATTCAAAGAGCCTTCTACGCCTAAAATATTCCAGGCTGACGAT
ATATTAGGCTGGTTATCCATTGACATTGATACACAATCACTACTTATAAAACGCTATCAAATGCTCATCGTTACCATTTT
TATTACTCTATTCGGTTTACTGATGGGTTTAACAATTCATTACTTCTTGTCTAAACGAATTTACATGCCTATTGCTCGAT
TGCGTCGAAGTATGAAGCAAATTTTAAGCAATGAATTTGAAACTGAAATTCGTGTTTCAAGTCCAGGAGAATTAGGAATA
ATTGAAAAAGGTTGCGCTCATTTACAACGACAATATTTAAATACAGTTCGTGATTTGAATCATCACATTGAAATCGCCAC
AGCAGATCTGCAACAAAGTCTCGAACTTCTGGAAGAAAAAAACATTGAGCTATCACTGGAAAAGAAAAAAACTGAAGAAA
AAAGTCGACAAAAATCAGAATTTATTGCCAACATGAGTCATGAAATTCGCACCCCAATGAATGGCGTGATTGGTTTTACA
AATGTTTTATTGGAAAGCAAGCTGGACCCTTTACAACTGGACTACGTTAAAACGATCAAATCATCAGCGCAGGATTTGTT
AAGTATCATCAATGCTATTCTGGATTTTTCTAAAATTGATGCGGGCAAATTAAATCTTGATTGCATCCCGCTAGACGTAA
GAGGTTGCATTGATGAGGTTTTATCCCTGGCAAGCCCCAATGCGCACAAAAAAGTAATCGATTTAATCCCGATTACAGAC
ATCAATGTGCCCAAAATGGTATTGGGTGACCCTTTAAGAATCAAACAAATCATCAGTAATCTGGTGACCAATGCAGTAAA
ATTTACAGATCATGGATACGTTCTTATACGCACTAAAATCGAGCAAGAAACAGATAAAGATTATACCTTACTATTTGCTA
TTACGGATACGGGAATAGGTATTTCACCAGAGGATCAAACGAAACTGTTTACTGCCTTCAATCAGGCAGACACCAGCATC
ACACGCCGTTACGGTGGCTCAGGATTAGGCTTGGTTATATGTAAAAAACTATGTGAAGAAATGCATGGACGTATTAGTCT
AACCAGTGAAATCAACAAAGGCTCTACTTTTAGCGCACGCATTAAAGTTGAAAAACTTGTGGCTTATGAGATTGAAAAAA
ATCAAACTCATCGTTTCGCCCATTTAAAAATCATTTGCTTTGATGACAATCCCCTCCATTTGGAAGCAATAGGTAATGGC
TTGGGATTTTGGGGTATAGAGGCTATACGCGTTGACTCATTTAATAAACTTTCCCGAACATTGACAAAACATAAAGATTG
TAAAATTGCCTTTATTAACGTCAACCAAGGATGTGAGCGACAAGCTGCTGAACTCATTGCCAAACACAAGCAAATTCCTT
TCGTGTTAATTTCTAAATGGCCTATTAATGATTTTGCGGCGCTTGGTGCTCGGGGTTTTCTTTACAAACCTATCAGCATC
CAAAAGCTTCAGGATCTGATTGAATCGATAGCCAATGAAAACCAAACTGAGAAAAATACGAACCAGGAACTGGATACTTT
ACGCGAACAGCTTCGTTTTCTTCATCCAGAGATACTGATTGCAGAAGACAACCCTGTCAATAAAATGCTATTAACATCCC
TATTAAACAATAATGCCAATATAACCACGGTTGACGATGGCGAAATGGCCGTTACTGCTTGTGAGGATAAAAAATTTGAC
ATGATTTTACTGGATCTGCATATGCCCAAACTTAATGGTTTGGAAGCAGCCAAAATGATACGTCAAAAATCCCTAATGAA
TAAACACTCTCCTATCGTTCTCATTACCGCCAGTAGCAGTGATCTGAGTTCTATCGATATGAAAAAATCTGGAGTTGATT
TTTGTTTTCAAAAACCTATAGATGAAAAGCAATTGTTAATCCAAATTCTTCGCATCGTTGATAAAATCAAACATGCTGCC
ATTGATTGGCAATTATGCGTTCAGAAAGTTTCAGGTAATCAAGCGCTTGCTGAAGAGTTCCTCGCCAAATTTATAGAAGA
ATTATATAAGAATCGTGAAGAGTTTATTGGGTTAATGCATCAAAAAAACGTAAAGGGCCTGGCTGATTTGGCTCATAAAT
TACATGGCGCCTGTTGTTTTTGTGGCGTGCCTATTTTACAAAAGAGAGTAGCTCAATTAGAGAAGCTTGCAAGACGAACA
GCTAATGCTGATAATTTAAGCGAAGCCTTTACCGATTTAATACAAAGTATTGATGCGGTGATTAGTGAATATGAAAATCA
GTACTCACAATAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (678-787)

• His Kinase A (phospho-acceptor) domain (HisKA) (298-362)

• Hpt domain (Hpt) (819-900)

• Single cache domain 4 (sCache_4) (36-180)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (409-524)

3D structure

• AlphaFold DB: Q5WVD9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
letS	Legionella pneumophila strain ERS1305867	99.011	100	0.99