Detailed information
Bioinformatically predicted
Overview
| Name | ccrB | Type | Machinery gene |
| Locus tag | A2I67_RS12770 | Genome accession | NZ_CP015533 |
| Coordinates | 2545007..2546638 (+) | Length | 543 a.a. |
| NCBI ID | WP_115359439.1 | Uniprot ID | - |
| Organism | Staphylococcus carnosus strain TMW 2.216 | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| SCCmec | 2511383..2586559 | 2545007..2546638 | within | 0 |
Gene organization within MGE regions
Location: 2511383..2586559
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| A2I67_RS12620 (A2I67_12335) | ccrA | 2511383..2512732 (+) | 1350 | WP_103211648.1 | recombinase family protein | Machinery gene |
| A2I67_RS12625 (A2I67_12340) | ccrB | 2512754..2514379 (+) | 1626 | WP_103211647.1 | recombinase family protein | Machinery gene |
| A2I67_RS12630 (A2I67_12345) | - | 2514854..2515192 (+) | 339 | WP_115359440.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| A2I67_RS12635 (A2I67_12350) | - | 2515288..2515599 (+) | 312 | WP_103211969.1 | DUF960 family protein | - |
| A2I67_RS12640 (A2I67_12355) | - | 2515613..2516113 (+) | 501 | WP_046099798.1 | DUF1643 domain-containing protein | - |
| A2I67_RS12645 (A2I67_12360) | - | 2516128..2516349 (+) | 222 | WP_046099797.1 | hypothetical protein | - |
| A2I67_RS12650 (A2I67_12365) | - | 2516414..2516662 (-) | 249 | WP_046099796.1 | hypothetical protein | - |
| A2I67_RS12655 (A2I67_12370) | - | 2516713..2517939 (-) | 1227 | WP_046099795.1 | restriction endonuclease subunit S | - |
| A2I67_RS12660 (A2I67_12375) | - | 2517932..2519488 (-) | 1557 | WP_046099794.1 | type I restriction-modification system subunit M | - |
| A2I67_RS12665 (A2I67_12380) | - | 2519489..2520070 (-) | 582 | WP_103211980.1 | restriction endonuclease subunit S | - |
| A2I67_RS12670 (A2I67_12385) | - | 2520160..2522952 (-) | 2793 | WP_046099792.1 | type I restriction endonuclease subunit R | - |
| A2I67_RS12675 (A2I67_12390) | - | 2523206..2524498 (-) | 1293 | WP_046099775.1 | NtaA/DmoA family FMN-dependent monooxygenase | - |
| A2I67_RS12680 (A2I67_12395) | - | 2524701..2525474 (-) | 774 | WP_046099774.1 | acetoin reductase | - |
| A2I67_RS12685 (A2I67_12400) | ccrA | 2525860..2527209 (+) | 1350 | WP_046099773.1 | recombinase family protein | Machinery gene |
| A2I67_RS12690 (A2I67_12405) | ccrB | 2527230..2528858 (+) | 1629 | WP_046099772.1 | recombinase family protein | Machinery gene |
| A2I67_RS12695 (A2I67_12410) | - | 2529260..2529388 (+) | 129 | Protein_2474 | NAD-dependent protein deacylase | - |
| A2I67_RS12700 (A2I67_12415) | deoB | 2529434..2530612 (-) | 1179 | WP_046099770.1 | phosphopentomutase | - |
| A2I67_RS12705 (A2I67_12420) | deoC | 2530641..2531303 (-) | 663 | WP_046099769.1 | deoxyribose-phosphate aldolase | - |
| A2I67_RS12710 (A2I67_12425) | - | 2531317..2532672 (-) | 1356 | WP_103211845.1 | MFS transporter | - |
| A2I67_RS12715 (A2I67_12430) | deoD | 2532685..2533392 (-) | 708 | WP_046099767.1 | purine-nucleoside phosphorylase | - |
| A2I67_RS12720 (A2I67_12435) | - | 2533735..2534472 (-) | 738 | WP_308669872.1 | GntR family transcriptional regulator | - |
| A2I67_RS12730 (A2I67_12445) | - | 2535365..2536619 (-) | 1255 | Protein_2480 | gluconate:H+ symporter | - |
| A2I67_RS12735 (A2I67_12450) | - | 2536638..2538083 (-) | 1446 | WP_103211844.1 | four-carbon acid sugar kinase family protein | - |
| A2I67_RS12740 (A2I67_12455) | - | 2538495..2539796 (-) | 1302 | WP_046099765.1 | ATP-binding protein | - |
| A2I67_RS12745 (A2I67_12460) | - | 2539835..2540884 (-) | 1050 | WP_046099764.1 | hypothetical protein | - |
| A2I67_RS12750 (A2I67_12465) | - | 2541021..2541314 (+) | 294 | WP_046099763.1 | DUF1413 domain-containing protein | - |
| A2I67_RS12755 (A2I67_12470) | - | 2541314..2543101 (+) | 1788 | WP_046099762.1 | DUF927 domain-containing protein | - |
| A2I67_RS12760 (A2I67_12475) | - | 2543170..2543445 (+) | 276 | WP_046099761.1 | hypothetical protein | - |
| A2I67_RS12765 (A2I67_12480) | ccrA | 2543637..2544986 (+) | 1350 | WP_103211957.1 | recombinase family protein | Machinery gene |
| A2I67_RS12770 (A2I67_12485) | ccrB | 2545007..2546638 (+) | 1632 | WP_115359439.1 | recombinase family protein | Machinery gene |
| A2I67_RS12775 (A2I67_12490) | - | 2547101..2547451 (+) | 351 | WP_046099759.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| A2I67_RS12780 | - | 2547887..2548081 (+) | 195 | WP_142382768.1 | hypothetical protein | - |
| A2I67_RS12785 (A2I67_12495) | - | 2548929..2550038 (-) | 1110 | WP_046099758.1 | NAD(P)-dependent alcohol dehydrogenase | - |
| A2I67_RS12790 (A2I67_12500) | - | 2550204..2551652 (+) | 1449 | WP_046099757.1 | aldehyde dehydrogenase family protein | - |
| A2I67_RS12795 (A2I67_12505) | - | 2551926..2552096 (+) | 171 | Protein_2493 | sodium:proline symporter | - |
| A2I67_RS12800 (A2I67_12510) | - | 2552630..2552980 (+) | 351 | WP_046099755.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| A2I67_RS12805 (A2I67_12515) | - | 2553067..2553378 (+) | 312 | WP_046099754.1 | DUF960 family protein | - |
| A2I67_RS12810 (A2I67_12520) | - | 2553394..2553897 (+) | 504 | WP_046099753.1 | DUF1643 domain-containing protein | - |
| A2I67_RS12815 (A2I67_12525) | - | 2553913..2554134 (+) | 222 | WP_046099752.1 | hypothetical protein | - |
| A2I67_RS12820 (A2I67_12530) | - | 2554228..2555358 (-) | 1131 | WP_235318574.1 | GIY-YIG nuclease family protein | - |
| A2I67_RS12825 (A2I67_12535) | - | 2555361..2557307 (-) | 1947 | WP_046099750.1 | DEAD/DEAH box helicase | - |
| A2I67_RS12830 | - | 2557297..2558613 (-) | 1317 | WP_253718433.1 | type IIL restriction-modification enzyme MmeI | - |
| A2I67_RS12835 | - | 2558588..2560045 (-) | 1458 | WP_235893313.1 | DNA methyltransferase | - |
| A2I67_RS12840 (A2I67_12545) | - | 2560554..2563427 (-) | 2874 | WP_115359438.1 | CDP-glycerol glycerophosphotransferase family protein | - |
| A2I67_RS12845 (A2I67_12550) | galU | 2563448..2564317 (-) | 870 | WP_103211973.1 | UTP--glucose-1-phosphate uridylyltransferase GalU | - |
| A2I67_RS12850 (A2I67_12555) | - | 2564611..2564859 (-) | 249 | WP_235893315.1 | hypothetical protein | - |
| A2I67_RS12855 (A2I67_12560) | - | 2565181..2565783 (-) | 603 | WP_103211965.1 | hypothetical protein | - |
| A2I67_RS12860 (A2I67_12565) | - | 2565919..2566401 (-) | 483 | WP_103211803.1 | hypothetical protein | - |
| A2I67_RS12865 (A2I67_12570) | - | 2566424..2566714 (-) | 291 | WP_103211804.1 | hypothetical protein | - |
| A2I67_RS12870 (A2I67_12575) | - | 2566771..2567643 (-) | 873 | WP_103211805.1 | HTH domain-containing protein | - |
| A2I67_RS12875 (A2I67_12580) | - | 2567827..2568258 (-) | 432 | WP_235893312.1 | JAB domain-containing protein | - |
| A2I67_RS12880 (A2I67_12585) | - | 2568279..2568785 (-) | 507 | WP_044291531.1 | DUF1643 domain-containing protein | - |
| A2I67_RS12885 (A2I67_12590) | - | 2568801..2569112 (-) | 312 | WP_053464988.1 | DUF960 family protein | - |
| A2I67_RS12890 (A2I67_12595) | - | 2569208..2569546 (-) | 339 | WP_103211806.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| A2I67_RS12895 (A2I67_12600) | - | 2569652..2571328 (-) | 1677 | WP_103211807.1 | recombinase family protein | - |
| A2I67_RS12900 (A2I67_12605) | - | 2571553..2573196 (-) | 1644 | WP_103211808.1 | DUF5906 domain-containing protein | - |
| A2I67_RS12905 (A2I67_12610) | - | 2573196..2573564 (-) | 369 | WP_103211809.1 | hypothetical protein | - |
| A2I67_RS12910 (A2I67_12615) | - | 2573557..2574657 (-) | 1101 | Protein_2516 | hypothetical protein | - |
| A2I67_RS12915 (A2I67_12620) | - | 2574868..2576193 (-) | 1326 | WP_115359437.1 | DUF6038 family protein | - |
| A2I67_RS12920 (A2I67_12625) | - | 2576246..2576533 (-) | 288 | WP_160149151.1 | Cthe_2314 family HEPN domain-containing protein | - |
| A2I67_RS12925 (A2I67_12630) | - | 2576535..2576978 (-) | 444 | WP_103211938.1 | Cthe_2314 family HEPN domain-containing protein | - |
| A2I67_RS12930 (A2I67_12635) | - | 2577150..2577806 (-) | 657 | WP_115359436.1 | hypothetical protein | - |
| A2I67_RS12935 (A2I67_12640) | - | 2578104..2579285 (-) | 1182 | WP_115359435.1 | PD-(D/E)XK nuclease family protein | - |
| A2I67_RS12940 (A2I67_12645) | - | 2579714..2581144 (+) | 1431 | WP_115359434.1 | DUF6038 family protein | - |
| A2I67_RS12945 (A2I67_12650) | - | 2581270..2583060 (+) | 1791 | WP_103211949.1 | DUF927 domain-containing protein | - |
| A2I67_RS12950 (A2I67_12655) | - | 2583128..2583385 (+) | 258 | WP_103211950.1 | hypothetical protein | - |
| A2I67_RS12955 (A2I67_12660) | ccrA | 2583563..2584912 (+) | 1350 | WP_103211951.1 | recombinase family protein | Machinery gene |
| A2I67_RS12960 (A2I67_12665) | ccrB | 2584934..2586559 (+) | 1626 | WP_103211952.1 | recombinase family protein | Machinery gene |
Sequence
Protein
Download Length: 543 a.a. Molecular weight: 62499.46 Da Isoelectric Point: 9.6504
>NTDB_id=180484 A2I67_RS12770 WP_115359439.1 2545007..2546638(+) (ccrB) [Staphylococcus carnosus strain TMW 2.216]
MQQLKQKRVGIYVRVSTEMQSAEGYSIDGQINQIKEYCNFHHFEVKDIYADRGISGKSMNRPALQRMLHDANKGHIDCVM
VYKTNRLARNTSDLLKIVEDLHKQNVEFFSLSERMEVNTSSGKLMLQILASFSEFERNTILENIYTGQHQRALEGYYQGN
LPLGYNNIPDNKKDLMINQHEANIVKYIFESYAKGHGYRKIANALNHKGYVTKKGNPFSISAVTYILSNPFYIGKIQFAK
YKDWNDKRRKGLNDKPVIAEGKHTPIISQSLWDKVQARKKQVSEKPQVHGKGTNILTGLISCPQCSASMSASTTVNTLKD
GTKKRIRYYSCSNFRNKGSKVCSANSVRADVIEKYVMDQILEIVKSDKVIKQVVERVNQEHQIDTSALNHDIAYKQQQYD
EVQIKLDNLIKTLEDNPDLTSVLKNTIHQYEKQLNDITNQINQLKQQQSAPKTIYDANEIATILRHIFKNIETMDKAQLK
ALYLTVIDHIDIRKDEHHKKQFYVTLKLNHEIIKQLFHNIPLDEVQLSTSSLLLSQTLYLPIS
MQQLKQKRVGIYVRVSTEMQSAEGYSIDGQINQIKEYCNFHHFEVKDIYADRGISGKSMNRPALQRMLHDANKGHIDCVM
VYKTNRLARNTSDLLKIVEDLHKQNVEFFSLSERMEVNTSSGKLMLQILASFSEFERNTILENIYTGQHQRALEGYYQGN
LPLGYNNIPDNKKDLMINQHEANIVKYIFESYAKGHGYRKIANALNHKGYVTKKGNPFSISAVTYILSNPFYIGKIQFAK
YKDWNDKRRKGLNDKPVIAEGKHTPIISQSLWDKVQARKKQVSEKPQVHGKGTNILTGLISCPQCSASMSASTTVNTLKD
GTKKRIRYYSCSNFRNKGSKVCSANSVRADVIEKYVMDQILEIVKSDKVIKQVVERVNQEHQIDTSALNHDIAYKQQQYD
EVQIKLDNLIKTLEDNPDLTSVLKNTIHQYEKQLNDITNQINQLKQQQSAPKTIYDANEIATILRHIFKNIETMDKAQLK
ALYLTVIDHIDIRKDEHHKKQFYVTLKLNHEIIKQLFHNIPLDEVQLSTSSLLLSQTLYLPIS
Nucleotide
Download Length: 1632 bp
>NTDB_id=180484 A2I67_RS12770 WP_115359439.1 2545007..2546638(+) (ccrB) [Staphylococcus carnosus strain TMW 2.216]
ATGCAACAACTCAAACAAAAACGTGTCGGTATCTATGTTCGTGTATCAACGGAAATGCAAAGTGCAGAGGGTTATAGTAT
CGACGGTCAAATCAATCAAATCAAAGAATATTGTAACTTCCATCATTTCGAAGTCAAAGATATATACGCTGATCGTGGTA
TTTCAGGAAAGTCTATGAACCGCCCTGCACTTCAACGTATGTTACATGATGCGAATAAAGGTCATATTGATTGTGTTATG
GTGTATAAAACAAATCGACTCGCACGTAATACATCAGACTTACTCAAAATTGTCGAAGATTTGCATAAACAAAATGTCGA
ATTTTTCAGTTTGTCTGAGCGTATGGAAGTCAACACTTCTTCTGGTAAACTCATGTTACAAATACTTGCAAGTTTTTCCG
AATTTGAAAGAAATACCATTTTAGAGAATATTTACACCGGACAACATCAAAGAGCCTTAGAAGGCTATTACCAAGGTAAT
CTTCCTTTAGGATATAATAACATACCAGATAATAAAAAAGATTTGATGATTAATCAGCATGAAGCTAATATTGTGAAATA
TATTTTTGAATCTTACGCCAAAGGTCATGGTTATCGTAAAATTGCCAACGCACTCAATCATAAAGGTTATGTCACTAAGA
AAGGTAATCCTTTTAGTATTTCAGCTGTTACTTATATTCTCTCAAACCCATTCTATATTGGTAAAATTCAATTCGCGAAA
TACAAAGATTGGAATGATAAACGTCGTAAAGGCTTGAATGATAAACCCGTAATTGCCGAAGGCAAACACACCCCTATTAT
TAGCCAATCATTATGGGATAAAGTCCAAGCACGTAAAAAACAAGTAAGTGAAAAACCACAAGTTCATGGTAAAGGAACCA
ATATTTTAACTGGATTAATTTCGTGTCCCCAATGTTCTGCTTCAATGTCTGCGAGCACAACAGTTAATACACTTAAAGAT
GGTACTAAAAAACGCATTCGCTACTATTCGTGTAGTAACTTTCGTAATAAAGGGTCAAAAGTATGTTCTGCGAATAGTGT
CAGAGCCGATGTAATTGAAAAATATGTTATGGATCAAATACTCGAAATTGTTAAAAGCGACAAGGTTATCAAGCAAGTCG
TTGAGCGTGTCAATCAAGAACATCAAATTGATACGTCTGCACTCAATCATGATATCGCATATAAGCAACAACAATATGAT
GAGGTCCAAATCAAATTAGATAACTTGATAAAAACGCTTGAAGATAATCCAGACTTAACATCTGTGCTTAAAAATACGAT
TCATCAGTATGAAAAACAACTCAATGACATCACAAATCAAATCAATCAACTTAAGCAACAACAAAGTGCTCCCAAAACAA
TATATGACGCTAATGAGATTGCGACTATATTACGTCATATATTCAAAAATATCGAAACCATGGATAAAGCACAACTCAAA
GCACTATACCTTACGGTCATAGACCACATTGATATTCGTAAAGACGAACATCATAAAAAACAGTTCTACGTCACATTAAA
ACTCAATCATGAAATCATTAAACAACTCTTCCATAATATCCCTCTCGACGAAGTGCAACTCAGCACTTCGTCTTTATTAT
TATCTCAAACACTCTATTTGCCTATCTCATAA
ATGCAACAACTCAAACAAAAACGTGTCGGTATCTATGTTCGTGTATCAACGGAAATGCAAAGTGCAGAGGGTTATAGTAT
CGACGGTCAAATCAATCAAATCAAAGAATATTGTAACTTCCATCATTTCGAAGTCAAAGATATATACGCTGATCGTGGTA
TTTCAGGAAAGTCTATGAACCGCCCTGCACTTCAACGTATGTTACATGATGCGAATAAAGGTCATATTGATTGTGTTATG
GTGTATAAAACAAATCGACTCGCACGTAATACATCAGACTTACTCAAAATTGTCGAAGATTTGCATAAACAAAATGTCGA
ATTTTTCAGTTTGTCTGAGCGTATGGAAGTCAACACTTCTTCTGGTAAACTCATGTTACAAATACTTGCAAGTTTTTCCG
AATTTGAAAGAAATACCATTTTAGAGAATATTTACACCGGACAACATCAAAGAGCCTTAGAAGGCTATTACCAAGGTAAT
CTTCCTTTAGGATATAATAACATACCAGATAATAAAAAAGATTTGATGATTAATCAGCATGAAGCTAATATTGTGAAATA
TATTTTTGAATCTTACGCCAAAGGTCATGGTTATCGTAAAATTGCCAACGCACTCAATCATAAAGGTTATGTCACTAAGA
AAGGTAATCCTTTTAGTATTTCAGCTGTTACTTATATTCTCTCAAACCCATTCTATATTGGTAAAATTCAATTCGCGAAA
TACAAAGATTGGAATGATAAACGTCGTAAAGGCTTGAATGATAAACCCGTAATTGCCGAAGGCAAACACACCCCTATTAT
TAGCCAATCATTATGGGATAAAGTCCAAGCACGTAAAAAACAAGTAAGTGAAAAACCACAAGTTCATGGTAAAGGAACCA
ATATTTTAACTGGATTAATTTCGTGTCCCCAATGTTCTGCTTCAATGTCTGCGAGCACAACAGTTAATACACTTAAAGAT
GGTACTAAAAAACGCATTCGCTACTATTCGTGTAGTAACTTTCGTAATAAAGGGTCAAAAGTATGTTCTGCGAATAGTGT
CAGAGCCGATGTAATTGAAAAATATGTTATGGATCAAATACTCGAAATTGTTAAAAGCGACAAGGTTATCAAGCAAGTCG
TTGAGCGTGTCAATCAAGAACATCAAATTGATACGTCTGCACTCAATCATGATATCGCATATAAGCAACAACAATATGAT
GAGGTCCAAATCAAATTAGATAACTTGATAAAAACGCTTGAAGATAATCCAGACTTAACATCTGTGCTTAAAAATACGAT
TCATCAGTATGAAAAACAACTCAATGACATCACAAATCAAATCAATCAACTTAAGCAACAACAAAGTGCTCCCAAAACAA
TATATGACGCTAATGAGATTGCGACTATATTACGTCATATATTCAAAAATATCGAAACCATGGATAAAGCACAACTCAAA
GCACTATACCTTACGGTCATAGACCACATTGATATTCGTAAAGACGAACATCATAAAAAACAGTTCTACGTCACATTAAA
ACTCAATCATGAAATCATTAAACAACTCTTCCATAATATCCCTCTCGACGAAGTGCAACTCAGCACTTCGTCTTTATTAT
TATCTCAAACACTCTATTTGCCTATCTCATAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrB | Staphylococcus aureus N315 |
82.657 |
99.816 |
0.825 |