Detailed information NTG0163349

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: AUC50_RS10465
• Genome accession: NZ_CP013621
• Coordinates: 2083940..2084983 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain RIVM3897
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2078940..2089983

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AUC50_RS10435 (AUC50_10410)	-	2079361..2080617 (-)	1257	WP_074347694.1	aminopeptidase	-
AUC50_RS10440 (AUC50_10415)	-	2080620..2080820 (-)	201	WP_000180460.1	DUF1128 family protein	-
AUC50_RS10445 (AUC50_10420)	-	2080967..2081431 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
AUC50_RS10450 (AUC50_10425)	-	2081438..2081713 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
AUC50_RS10455 (AUC50_10430)	-	2081991..2083208 (+)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
AUC50_RS10460 (AUC50_10435)	vraR	2083321..2083950 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
AUC50_RS10465 (AUC50_10440)	vraS	2083940..2084983 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
AUC50_RS10470 (AUC50_10445)	liaF	2084980..2085681 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
AUC50_RS10475 (AUC50_10450)	-	2085696..2086082 (-)	387	WP_001110182.1	hypothetical protein	-
AUC50_RS10480 (AUC50_10455)	map	2086299..2087057 (-)	759	WP_000636145.1	type I methionyl aminopeptidase	-
AUC50_RS10490 (AUC50_10470)	-	2087641..2088627 (+)	987	WP_000999712.1	FUSC family protein	-
AUC50_RS10495 (AUC50_10475)	-	2088816..2089229 (-)	414	WP_025174370.1	hypothetical protein	-
AUC50_RS10500 (AUC50_10480)	-	2089258..2089368 (-)	111	WP_014937049.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=163349 AUC50_RS10465 WP_001017131.1 2083940..2084983(-) (vraS) [Staphylococcus aureus strain RIVM3897]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=163349 AUC50_RS10465 WP_001017131.1 2083940..2084983(-) (vraS) [Staphylococcus aureus strain RIVM3897]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTTCTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAATTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAATTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1