Detailed information    

insolico Bioinformatically predicted

Overview

Name   comEC/celB   Type   Machinery gene
Locus tag   SanJ4211_RS04395 Genome accession   NZ_CP012805
Coordinates   871522..873750 (+) Length   742 a.a.
NCBI ID   WP_037613581.1    Uniprot ID   A0AAP6BQ17
Organism   Streptococcus anginosus strain J4211     
Function   ssDNA transport into the cell (predicted from homology)   
DNA binding and uptake

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
IScluster/Tn 869352..870703 871522..873750 flank 819


Gene organization within MGE regions


Location: 869352..873750
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SanJ4211_RS04390 (SanJ4211_0861) comEA/celA/cilE 870834..871538 (+) 705 WP_003024731.1 helix-hairpin-helix domain-containing protein Machinery gene
  SanJ4211_RS04395 (SanJ4211_0862) comEC/celB 871522..873750 (+) 2229 WP_037613581.1 DNA internalization-related competence protein ComEC/Rec2 Machinery gene

Sequence

Protein


Download         Length: 742 a.a.        Molecular weight: 85164.95 Da        Isoelectric Point: 10.0221

>NTDB_id=157706 SanJ4211_RS04395 WP_037613581.1 871522..873750(+) (comEC/celB) [Streptococcus anginosus strain J4211]
MSQWIKRFPIKPIYIAFLLVWLYFAIYQSSWLGWLGFIFLVICLFRFYSPKECFMTFMILSCFAGFFFVRREIAEQKTKV
EPSPIRQVAVLPDTIKVNGDSLSFRGKANRQTYQVYYKLKSKEEQLAFQNLSSLVTLTVEGEFEIPEKKRNFAGFDYQSY
LKTQGIYRILKVDTILSSQDRISLHPFEWLSSWRRKALVFIKNHFPNPMSNYMTGLLFGALDTSFDEMSNLYSSLGIIHL
FALSGMQVGFFMEGFRKLLLRLGFTQEMVRKCQYPFSFFYAGMTGFSVSVVRSLVQKLLSQHGITKLDNFALTMMILSLI
MPSFLLSAGGVLSCAYAFVISVIDFESLTSWRKVVVESSVISLGVLPILIFYFGEFQPWSILLTFVFSLIFDTMMLPGLM
FIFLFSPLIKLTQVNFLFEGLENSIRWIASVFGKPIVFGQPSPLLLIVMLLVLAILYDIRQNKKWVIFLSLFLSLLFFIN
KFPLQNEITMVDVGQGDSIFLRDWKGKNVLIDVGGREEIRTKEAWQKRATSSNAEKTLIPYLKSRGVDTIDTLVLTNPNP
DYAGDVLGVAKKFAIKKIYISRSSLSNADFLKKLRETNTFIHVIKQGDKLPIFDHHLQVLSGASKNDHSIVLYGQFFRTR
FLFASDLKEEEEAKLMQHYPKLKTDILKVGQHGAKSSSSSKFLQQIEPTVALISVGKNNQSKQPSQDTIERFAQLPAKVY
RTDEQGAVKFSGWTNWRLEMVK

Nucleotide


Download         Length: 2229 bp        

>NTDB_id=157706 SanJ4211_RS04395 WP_037613581.1 871522..873750(+) (comEC/celB) [Streptococcus anginosus strain J4211]
ATGTCACAGTGGATTAAAAGATTTCCGATTAAGCCGATTTACATTGCTTTTTTGCTCGTCTGGTTGTATTTTGCAATCTA
TCAAAGTAGCTGGTTAGGCTGGTTGGGTTTTATCTTTCTGGTGATTTGTCTTTTTCGCTTTTATTCACCGAAAGAATGTT
TCATGACCTTCATGATCCTCTCTTGTTTTGCTGGTTTTTTCTTTGTTCGTAGGGAAATAGCAGAGCAGAAGACGAAAGTA
GAACCTTCTCCCATAAGACAAGTGGCAGTTCTACCTGACACGATTAAGGTAAATGGTGATTCGCTTTCTTTTCGTGGTAA
AGCTAATAGGCAGACTTATCAAGTTTACTACAAATTGAAATCAAAGGAAGAACAGTTGGCTTTTCAAAATCTCTCTAGTC
TGGTTACATTGACCGTTGAAGGGGAATTTGAAATCCCTGAGAAGAAGCGTAATTTTGCTGGTTTTGATTACCAATCCTAT
TTAAAAACGCAAGGGATTTATCGAATTTTAAAAGTGGATACCATTTTATCGAGCCAAGATAGAATCAGCTTGCACCCTTT
TGAGTGGCTTTCTAGCTGGCGAAGAAAAGCACTGGTATTTATCAAGAACCATTTTCCAAATCCGATGAGTAATTACATGA
CAGGACTCTTATTTGGTGCCTTGGATACATCCTTTGACGAAATGAGCAATCTTTATTCTAGCTTGGGAATTATTCATTTA
TTTGCGCTGTCTGGCATGCAAGTTGGCTTTTTTATGGAGGGATTTCGCAAGTTACTGTTAAGGCTGGGGTTTACACAAGA
AATGGTTCGTAAATGCCAATATCCATTTTCTTTCTTTTATGCGGGAATGACTGGATTTTCAGTATCCGTTGTACGGAGCT
TAGTTCAGAAATTATTATCGCAACATGGTATCACTAAGTTAGATAATTTTGCTTTAACGATGATGATATTGTCCTTGATT
ATGCCGTCCTTTCTTTTGTCGGCAGGAGGAGTTCTCTCCTGTGCTTATGCTTTTGTCATTAGTGTGATAGATTTTGAAAG
TCTGACTTCTTGGCGAAAAGTTGTTGTAGAGAGTAGCGTTATTTCACTTGGTGTTTTACCAATTCTAATCTTTTACTTTG
GTGAATTTCAACCTTGGTCTATTTTGTTGACATTTGTTTTTTCACTAATTTTCGATACAATGATGCTGCCAGGCTTGATG
TTTATTTTTCTTTTTTCGCCTTTGATAAAGCTGACTCAAGTCAATTTTTTATTTGAAGGTTTAGAAAATAGTATTCGTTG
GATAGCAAGTGTCTTTGGTAAACCAATCGTTTTTGGGCAGCCCAGTCCGCTTTTGCTGATTGTCATGTTACTTGTACTAG
CTATTTTGTACGATATTCGGCAAAATAAAAAGTGGGTAATATTTCTTAGTCTGTTTCTTTCATTACTATTTTTCATAAAT
AAATTTCCTTTGCAAAACGAGATCACAATGGTTGATGTTGGACAAGGAGATAGTATTTTTCTGAGAGACTGGAAAGGAAA
AAATGTATTGATTGATGTTGGCGGACGTGAGGAAATTAGAACAAAAGAAGCTTGGCAAAAACGAGCAACTAGCTCAAATG
CAGAGAAAACTTTGATTCCTTACCTAAAAAGTCGTGGCGTAGATACGATTGATACTTTAGTCTTAACAAATCCTAATCCA
GATTATGCAGGAGATGTATTAGGAGTTGCTAAAAAGTTTGCAATAAAGAAAATTTATATTTCCAGAAGTAGTCTAAGCAA
TGCAGATTTCCTAAAGAAATTAAGGGAGACAAATACATTCATTCATGTCATAAAACAAGGTGACAAACTTCCTATTTTTG
ATCATCATTTGCAAGTTCTTTCGGGTGCTAGCAAGAACGACCATTCGATTGTTTTATATGGTCAGTTTTTCCGTACAAGA
TTTTTATTTGCAAGCGATTTGAAAGAAGAAGAGGAAGCAAAGTTGATGCAACATTATCCAAAGTTGAAAACAGATATCTT
GAAAGTCGGGCAACATGGAGCTAAAAGTTCATCAAGTTCAAAGTTTTTGCAACAAATAGAACCAACGGTTGCGCTCATTT
CTGTTGGGAAAAATAATCAATCTAAGCAACCTAGTCAAGATACAATAGAGCGATTTGCACAATTGCCTGCTAAAGTCTAT
CGGACAGATGAACAAGGGGCAGTTAAATTTTCAGGGTGGACAAACTGGCGATTAGAGATGGTCAAGTAA

Domains

Predicted by InterproScan.

Metallo-beta-lactamase superfamily (Lactamase_B)

(492-695)

Competence protein (Competence)

(216-461)

Domain of unknown function (DUF4131) (DUF4131)

(29-175)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comEC/celB Streptococcus mitis SK321

54.618

100

0.55
  comEC/celB Streptococcus mitis NCTC 12261

54.155

100

0.544
  comEC/celB Streptococcus pneumoniae TIGR4

53.681

100

0.54
  comEC/celB Streptococcus pneumoniae Rx1

52.878

100

0.532
  comEC/celB Streptococcus pneumoniae D39

52.878

100

0.532
  comEC/celB Streptococcus pneumoniae R6

52.878

100

0.532
  comEC Lactococcus lactis subsp. cremoris KW2

46.774

100

0.469

Multiple sequence alignment