Detailed information NTG0115740

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: SMUFR_RS00365
• Genome accession: NZ_CP007016
• Coordinates: 61515..62429 (+)
• Length: 304 a.a.
• NCBI ID: WP_002263400.1
• Uniprot ID: Q8DWI6
• Organism: Streptococcus mutans UA159-FR
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 56515..67429

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SMUFR_RS10970	-	56910..57007 (+)	98	Protein_47	phosphoribosylaminoimidazole carboxylase	-
SMUFR_RS00340 (SMUFR_0048)	-	57009..57272 (+)	264	WP_002263395.1	hypothetical protein	-
SMUFR_RS10760	-	57292..57517 (+)	226	Protein_49	phosphoribosylaminoimidazole carboxylase	-
SMUFR_RS00350 (SMUFR_0049)	-	57523..58818 (+)	1296	WP_002263397.1	hypothetical protein	-
SMUFR_RS00355 (SMUFR_0050)	purB	59128..60426 (+)	1299	WP_002263398.1	adenylosuccinate lyase	-
SMUFR_RS00360 (SMUFR_0051)	-	60446..61132 (+)	687	WP_002263399.1	DNA alkylation repair protein	-
SMUFR_RS00365 (SMUFR_0052)	comR	61515..62429 (+)	915	WP_002263400.1	helix-turn-helix domain-containing protein	Regulator
SMUFR_RS00370 (SMUFR_0053)	-	62963..64804 (-)	1842	WP_002263401.1	carbohydrate-binding domain-containing protein	-
SMUFR_RS00375 (SMUFR_0054)	ruvB	65140..66135 (+)	996	WP_002263402.1	Holliday junction branch migration DNA helicase RuvB	-
SMUFR_RS00380 (SMUFR_0055)	-	66173..66598 (+)	426	WP_002263403.1	low molecular weight protein-tyrosine-phosphatase	-
SMUFR_RS00385 (SMUFR_0056)	-	66663..67046 (+)	384	WP_011074470.1	membrane protein	-

Sequence

Protein

• Length: 304 a.a.
• Molecular weight: 35247.28 Da
• Isoelectric Point: 4.8341

>NTDB_id=115740 SMUFR_RS00365 WP_002263400.1 61515..62429(+) (comR) [Streptococcus mutans UA159-FR]
MLKDFGKKIKSLRLEKGLTKEAVCLDESQLSTRQLTRIESGQSTPTLNKAVYIAGRLGVTLGYLTDGENVELPSRYKELK
YLLLRTPTYGDQQRLAEKETYFDEIFSQFYDDLPEEEQLIIDGLQSKLDIHFSDNIDFGVGILNDYFDQILRKTNYQVND
LILIDLYFSCLTVSGLDSAIFDSRKYNQLLETLLKQVDCLPLEDLFVLNNVLLNNFGLLLELKKYDFVKQLIAVSNKIMD
RTHDFQKKPIVNLLTWKHHLFVEKDYAEAKKSYDAAILFAQLTENINLRENLEKEWQKDSQNGT

Nucleotide

• Length: 915 bp

>NTDB_id=115740 SMUFR_RS00365 WP_002263400.1 61515..62429(+) (comR) [Streptococcus mutans UA159-FR]
ATGTTAAAAGATTTTGGGAAGAAAATTAAGAGCCTGAGGTTAGAAAAGGGGCTGACCAAAGAAGCTGTCTGCCTTGATGA
ATCTCAATTGTCAACACGGCAGTTGACCAGAATTGAATCAGGACAGTCTACGCCAACTCTTAATAAAGCTGTTTATATTG
CAGGACGTTTAGGAGTGACGCTTGGCTATTTAACGGACGGAGAAAATGTTGAGTTACCCAGTCGTTATAAAGAACTAAAG
TATTTATTATTACGAACGCCAACCTATGGCGACCAACAAAGATTAGCTGAAAAAGAAACCTATTTTGACGAGATTTTTAG
TCAGTTTTATGATGATTTGCCTGAAGAAGAACAATTGATTATTGATGGCTTACAATCGAAACTAGATATTCATTTTAGTG
ACAATATCGATTTTGGCGTTGGTATTTTAAATGACTATTTTGATCAGATTTTAAGAAAAACCAATTATCAGGTCAATGAT
TTGATTCTGATTGATCTCTATTTTTCCTGCTTAACTGTTAGTGGTTTGGATTCAGCTATTTTTGATTCAAGAAAATATAA
TCAATTATTGGAGACATTGCTTAAGCAGGTAGACTGCCTTCCATTGGAAGATCTTTTCGTTTTAAATAATGTTTTATTGA
ATAATTTTGGACTCCTCTTAGAATTGAAAAAATATGATTTTGTTAAGCAGCTTATTGCTGTCAGCAATAAAATCATGGAT
AGAACTCATGATTTTCAAAAAAAGCCTATTGTTAATCTTCTGACATGGAAGCATCATTTATTTGTTGAAAAAGATTATGC
GGAAGCTAAAAAGAGCTATGATGCTGCTATCTTATTTGCCCAGTTAACAGAAAACATTAATTTAAGAGAAAATTTGGAGA
AAGAATGGCAAAAAGATTCTCAGAACGGGACATAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (9-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

3D structure

• PDB: 7N10
• PDB: 7N1N

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus mutans UA159	100	100	1
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	52.778	94.737	0.5
comR	Streptococcus pyogenes MGAS315	47.157	98.355	0.464
comR	Streptococcus pyogenes MGAS8232	46.358	99.342	0.461
comR	Streptococcus suis P1/7	43.813	98.355	0.431
comR	Streptococcus suis 05ZYH33	43.813	98.355	0.431
comR	Streptococcus suis D9	37	98.684	0.365