Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   DQN21_RS02165 Genome accession   NZ_LS483409
Coordinates   378757..379512 (+) Length   251 a.a.
NCBI ID   WP_009853397.1    Uniprot ID   A0A060RH68
Organism   Streptococcus gallolyticus strain NCTC13773     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 373757..384512
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQN21_RS02150 (NCTC13773_00421) - 374166..375737 (-) 1572 WP_009853395.1 ABC transporter permease subunit -
  DQN21_RS02155 (NCTC13773_00422) - 375870..377765 (+) 1896 WP_077496195.1 DUF2207 domain-containing protein -
  DQN21_RS02160 (NCTC13773_00423) - 377817..378656 (+) 840 WP_003063292.1 undecaprenyl-diphosphate phosphatase -
  DQN21_RS02165 (NCTC13773_00424) mecA 378757..379512 (+) 756 WP_009853397.1 adaptor protein MecA Regulator
  DQN21_RS02170 (NCTC13773_00425) - 379514..380677 (+) 1164 WP_077496197.1 glycosyltransferase family 4 protein -
  DQN21_RS02175 (NCTC13773_00426) sufC 380791..381561 (+) 771 WP_003063299.1 Fe-S cluster assembly ATPase SufC -
  DQN21_RS02180 (NCTC13773_00427) sufD 381635..382897 (+) 1263 WP_077496199.1 Fe-S cluster assembly protein SufD -
  DQN21_RS02185 (NCTC13773_00428) - 382899..384131 (+) 1233 WP_077496201.1 cysteine desulfurase -

Sequence

Protein


Download         Length: 251 a.a.        Molecular weight: 28762.55 Da        Isoelectric Point: 4.0664

>NTDB_id=1140545 DQN21_RS02165 WP_009853397.1 378757..379512(+) (mecA) [Streptococcus gallolyticus strain NCTC13773]
MEMKQISETTLKITISMEDLEERGMELKDFLIPQEKTEEFFYSVMDELDLPDNFKDSGMLSFRVTPRKDRIDVFVTKSEI
NKEINFEDLAAFDDVSNMSPEEFFKTLEQTMLSKGDTEAHEKLGKIEEMMEGAVEEVLTEQAQAEPTEEDINPSDYVHYV
LDFPTLEAVVAFAKAIDFPVEASELYKDGGLYHMTILLDLQNHPSYYANLMYARLLEYASAGTKTRAYLQEHGVEMLADD
AVAKLKMIELV

Nucleotide


Download         Length: 756 bp        

>NTDB_id=1140545 DQN21_RS02165 WP_009853397.1 378757..379512(+) (mecA) [Streptococcus gallolyticus strain NCTC13773]
ATGGAAATGAAACAGATTAGCGAGACAACGCTAAAAATAACGATTAGTATGGAAGATTTAGAAGAACGTGGCATGGAGTT
GAAAGACTTTTTGATTCCACAAGAAAAGACAGAAGAGTTCTTCTACTCAGTAATGGACGAATTAGATTTACCAGATAATT
TCAAAGATAGTGGAATGCTTAGCTTTCGTGTGACACCAAGAAAAGACCGTATTGATGTCTTTGTTACAAAATCTGAGATC
AATAAAGAAATTAATTTTGAAGATTTAGCTGCATTCGACGACGTGTCAAACATGTCACCTGAGGAATTTTTCAAAACATT
GGAACAAACAATGCTTTCTAAAGGTGATACTGAGGCGCATGAAAAATTAGGAAAAATCGAAGAAATGATGGAAGGTGCTG
TTGAGGAAGTTCTCACAGAACAAGCTCAAGCAGAGCCAACAGAAGAGGATATTAATCCATCTGATTATGTTCATTATGTC
CTTGATTTTCCAACACTTGAAGCTGTCGTAGCTTTTGCTAAAGCAATTGATTTTCCAGTTGAAGCATCAGAACTCTACAA
AGATGGCGGTCTTTACCACATGACCATTTTACTTGATTTGCAAAATCATCCGTCTTACTATGCGAATTTGATGTATGCTC
GTTTGTTGGAATATGCTAGCGCAGGTACAAAAACGCGTGCTTATTTGCAAGAGCACGGTGTTGAAATGTTAGCAGATGAC
GCTGTTGCAAAATTAAAAATGATTGAGTTGGTATAA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-245)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A060RH68

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus mutans UA159

67.742

98.805

0.669
  mecA Streptococcus thermophilus LMD-9

60.729

98.406

0.598
  mecA Streptococcus thermophilus LMG 18311

60.324

98.406

0.594
  mecA Streptococcus pneumoniae Rx1

48.617

100

0.49
  mecA Streptococcus pneumoniae D39

48.617

100

0.49
  mecA Streptococcus pneumoniae R6

48.617

100

0.49
  mecA Streptococcus pneumoniae TIGR4

48.617

100

0.49

Multiple sequence alignment