Detailed information NTG1111656

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: HMPREF9319_RS00135
• Genome accession: NZ_GL397128
• Coordinates: 23357..24256 (+)
• Length: 299 a.a.
• NCBI ID: WP_003062822.1
• Uniprot ID: A0AAW6YMN1
• Organism: Streptococcus equinus ATCC 700338
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 18357..29256

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HMPREF9319_RS00110 (HMPREF9319_0017)	-	19557..20006 (+)	450	WP_003062811.1	DUF523 domain-containing protein	-
HMPREF9319_RS00115 (HMPREF9319_0018)	purE	20006..20494 (+)	489	WP_003062813.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
HMPREF9319_RS00120 (HMPREF9319_0019)	purK	20481..21572 (+)	1092	WP_003062815.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
HMPREF9319_RS00125 (HMPREF9319_0020)	-	21592..21816 (+)	225	WP_003062817.1	hypothetical protein	-
HMPREF9319_RS00130 (HMPREF9319_0021)	purB	21906..23204 (+)	1299	WP_003062820.1	adenylosuccinate lyase	-
HMPREF9319_RS00135 (HMPREF9319_0022)	comR	23357..24256 (+)	900	WP_003062822.1	helix-turn-helix domain-containing protein	Regulator
-	comS	24333..24377 (+)	45	-	-	Regulator
HMPREF9319_RS00140 (HMPREF9319_0023)	-	25300..25731 (+)	432	WP_003062824.1	low molecular weight protein-tyrosine-phosphatase	-
HMPREF9319_RS00145 (HMPREF9319_0024)	-	25751..26131 (+)	381	WP_003062826.1	MORN repeat-containing protein	-
HMPREF9319_RS00150 (HMPREF9319_0025)	-	26128..27921 (+)	1794	WP_003062827.1	acyltransferase family protein	-

Sequence

Protein

• Length: 299 a.a.
• Molecular weight: 34901.04 Da
• Isoelectric Point: 4.9515

>NTDB_id=1111656 HMPREF9319_RS00135 WP_003062822.1 23357..24256(+) (comR) [Streptococcus equinus ATCC 700338]
MEKFGIKVRALREKKGISREEFCGDETELSVRQLARIEKGQSVPTLNKVGYIAKVLGVTIGELTDGKNLELSTRYKELKY
LLLRTPTYGDEERLKRQTSYFDEISEKYYEVIPEEERLIIDCLQSKLDVHFSDDVNFGEGILNDYFDQVIRKKNFQINDL
VLIDLYFACLASAKSFVGIYSLDLYDKLMECLLDQENLSPETSLILNNVLLNNVDLVLRFHRESFMKRIIIKSDTIMTSV
HDFQRRPVLSLVEWKYYLQFKKDFLAAQKSYSNAILFANLIGDTYLENKLIEEWNNDTT

Nucleotide

• Length: 900 bp

>NTDB_id=1111656 HMPREF9319_RS00135 WP_003062822.1 23357..24256(+) (comR) [Streptococcus equinus ATCC 700338]
TTGGAAAAGTTTGGGATTAAAGTACGTGCATTAAGAGAGAAAAAGGGAATTTCACGTGAGGAATTCTGTGGTGATGAAAC
AGAATTGTCTGTGAGACAGCTAGCTAGAATTGAAAAAGGACAATCTGTCCCAACTCTTAATAAGGTGGGATATATTGCAA
AAGTATTGGGAGTAACCATTGGTGAGTTAACTGATGGTAAAAATTTAGAACTTTCCACTAGGTATAAGGAGTTAAAGTAT
TTATTATTACGAACACCGACCTATGGGGATGAGGAACGTCTTAAGAGACAAACTTCATATTTTGATGAAATTTCGGAAAA
GTACTATGAAGTTATACCTGAAGAAGAACGTTTAATTATTGATTGTTTACAATCGAAGCTTGATGTTCATTTCAGTGATG
ATGTTAATTTTGGTGAAGGAATTTTAAATGATTACTTTGACCAAGTTATACGAAAGAAGAACTTTCAAATTAATGATTTA
GTTTTGATAGATTTATATTTTGCTTGCCTTGCTTCTGCTAAATCGTTTGTGGGAATCTATAGTTTAGATTTGTATGATAA
ATTAATGGAGTGTTTACTAGATCAAGAAAATCTTTCACCAGAAACTTCTTTGATTTTAAATAATGTTTTGTTAAATAATG
TAGATTTGGTTTTACGATTCCATAGAGAATCTTTTATGAAACGAATTATTATAAAAAGTGACACTATCATGACAAGTGTT
CATGATTTTCAAAGACGTCCAGTTTTAAGTTTAGTTGAGTGGAAATATTATTTACAATTTAAAAAAGATTTTTTAGCGGC
ACAAAAATCTTACTCCAATGCTATTTTATTTGCTAACTTAATTGGAGATACTTATTTGGAAAATAAGTTAATAGAAGAAT
GGAATAATGACACAACATGA

Domains

Predicted by InterproScan.

• ComR tetratricopeptide (ComR_TPR) (74-294)

• Helix-turn-helix (HTH_3) (8-63)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	71.429	95.987	0.686
comR	Streptococcus mutans UA159	54.181	100	0.542
comR	Streptococcus pyogenes MGAS8232	49	100	0.492
comR	Streptococcus pyogenes MGAS315	46.644	99.666	0.465
comR	Streptococcus suis 05ZYH33	40.268	99.666	0.401
comR	Streptococcus suis P1/7	40.268	99.666	0.401
comR	Streptococcus suis D9	38.333	100	0.385