99989

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 316521..317134 Replicon chromosome
Accession NZ_CP027722
Organism Pseudomonas chlororaphis subsp. aureofaciens strain C50

Toxin (Protein)


Gene name hicA Uniprot ID A0A285EYZ4
Locus tag C4K11_RS01385 Protein ID WP_009041685.1
Coordinates 316521..316703 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A554PT90
Locus tag C4K11_RS01390 Protein ID WP_009046450.1
Coordinates 316733..317134 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4K11_RS01360 311704..313668 + 1965 WP_164485207.1 choline transporter BetT -
C4K11_RS01365 313781..314038 - 258 WP_009046444.1 hypothetical protein -
C4K11_RS01370 314091..314579 - 489 WP_124354496.1 DoxX family protein -
C4K11_RS01375 314636..315376 - 741 WP_016702555.1 SDR family oxidoreductase -
C4K11_RS01380 315506..316396 + 891 WP_041985374.1 LysR family transcriptional regulator -
C4K11_RS01385 316521..316703 + 183 WP_009041685.1 type II toxin-antitoxin system HicA family toxin Toxin
C4K11_RS01390 316733..317134 + 402 WP_009046450.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
C4K11_RS01395 317704..318741 + 1038 WP_016702559.1 L-glyceraldehyde 3-phosphate reductase -
C4K11_RS01400 318872..319300 - 429 WP_023970008.1 type II toxin-antitoxin system VapC family toxin -
C4K11_RS01405 319297..319542 - 246 WP_016702561.1 plasmid stabilization protein -
C4K11_RS01410 319682..320521 - 840 WP_124354497.1 taurine dioxygenase -
C4K11_RS01415 320757..321596 - 840 WP_009046455.1 taurine ABC transporter permease TauC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6933.08 Da        Isoelectric Point: 10.4588

>T99989 WP_009041685.1 NZ_CP027722:316521-316703 [Pseudomonas chlororaphis subsp. aureofaciens]
MRSRELIRMIEEDGWYLIAVKGSHHQYKHLHKPGRVTIPHPDADLPRGTIHSILKQAGLK

Download         Length: 183 bp

>T99989 NZ_CP027722:316521-316703 [Pseudomonas chlororaphis subsp. aureofaciens]
ATGCGCAGTCGGGAACTGATCAGGATGATCGAGGAGGACGGGTGGTATCTGATCGCGGTCAAAGGCAGTCATCACCAATA
CAAGCATCTGCACAAGCCGGGACGGGTCACTATCCCTCACCCGGATGCGGATCTGCCCAGGGGCACGATCCACAGCATCT
TGAAACAGGCGGGCCTGAAATGA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14596.44 Da        Isoelectric Point: 4.9133

>AT99989 WP_009046450.1 NZ_CP027722:316733-317134 [Pseudomonas chlororaphis subsp. aureofaciens]
MKFPVVLHKDADSGYGVIVPDVPGCFSAGHTAAQAFENVKEALSLHYEGLVADGEPLPQVHEVDVHIDNPDYAGGVWGVI
EFDITPYFGKAVRFNATLPEQLLERIDQTVKRDQRYRSRSGFLAAAALRELSA

Download         Length: 402 bp

>AT99989 NZ_CP027722:316733-317134 [Pseudomonas chlororaphis subsp. aureofaciens]
ATGAAATTCCCGGTCGTGCTGCACAAGGATGCCGACTCCGGATATGGAGTGATCGTCCCCGATGTGCCGGGCTGTTTTTC
CGCCGGTCATACCGCTGCGCAAGCCTTCGAGAATGTGAAAGAGGCCCTGTCGCTGCATTATGAAGGCCTGGTCGCCGATG
GTGAGCCGCTGCCCCAGGTGCATGAGGTCGACGTGCATATCGACAATCCCGATTACGCCGGTGGCGTGTGGGGCGTGATC
GAGTTCGACATCACGCCTTACTTCGGCAAGGCGGTGCGTTTCAATGCGACGTTGCCGGAGCAACTGTTGGAGCGCATCGA
CCAGACGGTGAAGCGCGACCAGCGCTACCGTTCGCGCTCGGGCTTTCTCGCGGCAGCGGCATTGCGCGAACTCTCCGCCT
AG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A285EYZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A554PT90

References