Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 6175844..6176433 Replicon chromosome
Accession NZ_CP027721
Organism Pseudomonas chlororaphis subsp. aureofaciens strain ChPhzTR36

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag C4K12_RS27665 Protein ID WP_124315434.1
Coordinates 6176134..6176433 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag C4K12_RS27660 Protein ID WP_007924096.1
Coordinates 6175844..6176137 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4K12_RS27640 6171385..6172548 - 1164 WP_124315432.1 acyltransferase -
C4K12_RS27645 6172743..6173933 - 1191 WP_009051073.1 serine hydrolase -
C4K12_RS27650 6174060..6174947 + 888 WP_009051074.1 LysR family transcriptional regulator -
C4K12_RS27655 6175319..6175711 + 393 WP_124315433.1 hypothetical protein -
C4K12_RS27660 6175844..6176137 - 294 WP_007924096.1 putative addiction module antidote protein Antitoxin
C4K12_RS27665 6176134..6176433 - 300 WP_124315434.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C4K12_RS27670 6176604..6177053 + 450 WP_124315435.1 DUF3828 domain-containing protein -
C4K12_RS27675 6177078..6178088 - 1011 WP_173424526.1 NAD(P)-dependent alcohol dehydrogenase -
C4K12_RS27680 6178146..6178445 - 300 WP_009051080.1 ArsR family transcriptional regulator -
C4K12_RS27685 6178509..6179600 - 1092 WP_009051081.1 nitrite reductase, copper-containing -
C4K12_RS27690 6179826..6180068 + 243 WP_007924102.1 exodeoxyribonuclease VII small subunit -
C4K12_RS27695 6180065..6180952 + 888 WP_009051083.1 (2E,6E)-farnesyl diphosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-94)

Antitoxin

Uncharacterized protein HI1420

(6-91)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11226.95 Da        Isoelectric Point: 10.4277

>T99987 WP_124315434.1 NZ_CP027721:c6176433-6176134 [Pseudomonas chlororaphis subsp. aureofaciens]
MIEIKQTATFMEWENRLKDSRARALIAARIFRLANGLAGDVSPVGEGVSELRIHYGPGYRVYFQQLGSQLVILLCGGDKS
RQGRDIELAKYLARRWSRS

Download         Length: 300 bp

>T99987 NZ_CP027721:c6176433-6176134 [Pseudomonas chlororaphis subsp. aureofaciens]
ATGATCGAGATCAAACAGACCGCGACCTTTATGGAGTGGGAAAACAGGCTCAAGGATTCCAGAGCCAGGGCGTTGATCGC
TGCGCGGATTTTTCGCCTGGCCAACGGCCTTGCCGGGGACGTGTCCCCGGTGGGCGAAGGCGTCAGCGAGTTGCGCATCC
ATTACGGGCCGGGCTACCGAGTTTATTTCCAGCAGCTTGGTTCGCAACTTGTCATTTTGTTATGCGGCGGCGACAAGAGT
CGCCAGGGCCGCGATATCGAACTGGCCAAATACCTGGCCCGTCGTTGGAGTCGATCATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10430.94 Da        Isoelectric Point: 5.6558

>AT99987 WP_007924096.1 NZ_CP027721:c6176137-6175844 [Pseudomonas chlororaphis subsp. aureofaciens]
MNEPLFDYDPATALRDPQAIALFMADAFETGDAGYIAKALGVVARAKGMTELAHETGLSREQLYRSFSDKGNPTLKTLLA
VMRALGLDMTARVHGAS

Download         Length: 294 bp

>AT99987 NZ_CP027721:c6176137-6175844 [Pseudomonas chlororaphis subsp. aureofaciens]
ATGAACGAACCGCTATTCGACTATGACCCCGCCACGGCCTTGCGCGACCCGCAAGCCATTGCCCTGTTCATGGCGGACGC
CTTCGAGACCGGCGATGCCGGCTACATCGCCAAAGCCCTGGGCGTGGTGGCGCGGGCCAAGGGCATGACCGAACTGGCCC
ATGAAACCGGGCTGTCCCGCGAGCAGCTGTACCGCTCGTTCAGTGACAAGGGCAACCCGACCCTGAAGACCCTGCTGGCG
GTGATGCGCGCCCTGGGGCTGGATATGACGGCGCGGGTGCATGGGGCGTCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References