Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 322494..323107 Replicon chromosome
Accession NZ_CP027720
Organism Pseudomonas chlororaphis subsp. aureofaciens strain DSM 6698

Toxin (Protein)


Gene name hicA Uniprot ID A0A285EYZ4
Locus tag C4K13_RS01410 Protein ID WP_009041685.1
Coordinates 322494..322676 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A554PT90
Locus tag C4K13_RS01415 Protein ID WP_009046450.1
Coordinates 322706..323107 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4K13_RS01380 318270..318527 - 258 WP_009046444.1 hypothetical protein -
C4K13_RS01385 318580..319068 - 489 WP_041985368.1 DoxX family protein -
C4K13_RS01390 319142..320037 - 896 Protein_267 SDR family oxidoreductase -
C4K13_RS01395 320066..320575 - 510 WP_009046447.1 DUF1097 domain-containing protein -
C4K13_RS01400 320609..321349 - 741 WP_016702555.1 SDR family oxidoreductase -
C4K13_RS01405 321479..322369 + 891 WP_041985374.1 LysR family transcriptional regulator -
C4K13_RS01410 322494..322676 + 183 WP_009041685.1 type II toxin-antitoxin system HicA family toxin Toxin
C4K13_RS01415 322706..323107 + 402 WP_009046450.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
C4K13_RS01420 323677..324714 + 1038 WP_016702559.1 L-glyceraldehyde 3-phosphate reductase -
C4K13_RS01425 324844..325272 - 429 WP_041985377.1 type II toxin-antitoxin system VapC family toxin -
C4K13_RS01430 325269..325514 - 246 WP_009046453.1 plasmid stabilization protein -
C4K13_RS01435 325654..326493 - 840 WP_009046454.1 taurine dioxygenase -
C4K13_RS01440 326729..327568 - 840 WP_009046455.1 taurine ABC transporter permease TauC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6933.08 Da        Isoelectric Point: 10.4588

>T99975 WP_009041685.1 NZ_CP027720:322494-322676 [Pseudomonas chlororaphis subsp. aureofaciens]
MRSRELIRMIEEDGWYLIAVKGSHHQYKHLHKPGRVTIPHPDADLPRGTIHSILKQAGLK

Download         Length: 183 bp

>T99975 NZ_CP027720:322494-322676 [Pseudomonas chlororaphis subsp. aureofaciens]
ATGCGCAGTCGGGAACTGATCAGGATGATCGAGGAGGACGGGTGGTATCTGATCGCGGTCAAAGGCAGTCATCACCAATA
CAAGCATCTGCACAAGCCGGGACGGGTCACTATCCCTCACCCGGATGCGGATCTGCCCAGGGGCACGATCCACAGCATCT
TGAAACAGGCGGGCCTGAAATGA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14596.44 Da        Isoelectric Point: 4.9133

>AT99975 WP_009046450.1 NZ_CP027720:322706-323107 [Pseudomonas chlororaphis subsp. aureofaciens]
MKFPVVLHKDADSGYGVIVPDVPGCFSAGHTAAQAFENVKEALSLHYEGLVADGEPLPQVHEVDVHIDNPDYAGGVWGVI
EFDITPYFGKAVRFNATLPEQLLERIDQTVKRDQRYRSRSGFLAAAALRELSA

Download         Length: 402 bp

>AT99975 NZ_CP027720:322706-323107 [Pseudomonas chlororaphis subsp. aureofaciens]
ATGAAATTCCCGGTCGTGCTGCACAAGGATGCCGACTCCGGATATGGAGTGATCGTCCCCGATGTGCCGGGCTGTTTTTC
CGCCGGTCATACCGCTGCGCAAGCCTTCGAGAATGTGAAAGAGGCCCTGTCGCTGCATTATGAAGGCCTGGTCGCCGATG
GTGAGCCGCTGCCCCAGGTGCATGAGGTCGACGTGCATATCGACAATCCCGATTACGCCGGTGGCGTGTGGGGGGTGATC
GAGTTCGACATCACGCCTTACTTCGGCAAGGCGGTGCGTTTCAATGCGACGTTGCCGGAGCAACTGTTGGAGCGCATCGA
CCAGACGGTGAAGCGCGACCAGCGCTACCGTTCGCGCTCGGGCTTTCTCGCGGCAGCGGCATTGCGCGAACTCTCCGCCT
AG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A285EYZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A554PT90

References