Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbE-relB/ParE-YafN
Location 211364..211880 Replicon chromosome
Accession NZ_CP027720
Organism Pseudomonas chlororaphis subsp. aureofaciens strain DSM 6698

Toxin (Protein)


Gene name stbE Uniprot ID A0A285EY61
Locus tag C4K13_RS00885 Protein ID WP_009041601.1
Coordinates 211599..211880 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A554PKE4
Locus tag C4K13_RS00880 Protein ID WP_009046356.1
Coordinates 211364..211609 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4K13_RS00855 207132..208127 + 996 WP_041985268.1 aspartyl beta-hydroxylase -
C4K13_RS00860 208093..208851 - 759 WP_009046352.1 slipin family protein -
C4K13_RS00865 208853..210238 - 1386 WP_009046353.1 nodulation protein NfeD -
C4K13_RS00870 210462..210923 + 462 WP_016705004.1 YbaK/EbsC family protein -
C4K13_RS00875 211054..211299 + 246 WP_009046355.1 DUF2789 domain-containing protein -
C4K13_RS00880 211364..211609 + 246 WP_009046356.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
C4K13_RS00885 211599..211880 + 282 WP_009041601.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C4K13_RS00890 212013..212441 + 429 WP_009046358.1 winged helix DNA-binding protein -
C4K13_RS00895 212438..214522 + 2085 WP_041985273.1 FUSC family protein -
C4K13_RS00900 214519..214728 + 210 WP_041985274.1 DUF1656 domain-containing protein -
C4K13_RS00905 214725..215618 + 894 WP_041985277.1 HlyD family secretion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-82)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(8-70)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10879.81 Da        Isoelectric Point: 10.5797

>T99974 WP_009041601.1 NZ_CP027720:211599-211880 [Pseudomonas chlororaphis subsp. aureofaciens]
MTYKLQFLPSARKEWDKLGHTLREQFKKKLAERLEMPRVPADALHGMADCYKIKLKASGYRLVYQVIEDQVVVSVVAVGK
RERSAVYERARKR

Download         Length: 282 bp

>T99974 NZ_CP027720:211599-211880 [Pseudomonas chlororaphis subsp. aureofaciens]
ATGACTTATAAGCTCCAGTTTCTGCCTTCGGCGCGCAAGGAATGGGACAAGCTCGGTCATACCCTGCGCGAGCAATTCAA
GAAGAAGCTGGCCGAGCGCCTGGAAATGCCGCGGGTGCCCGCGGACGCCCTTCACGGTATGGCGGACTGCTACAAGATCA
AGCTCAAGGCCTCTGGCTATCGCCTGGTTTACCAAGTGATCGAGGATCAGGTCGTGGTTTCGGTGGTGGCCGTGGGCAAA
CGTGAACGCAGTGCCGTGTATGAGCGGGCACGAAAGCGCTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8814.14 Da        Isoelectric Point: 4.7164

>AT99974 WP_009046356.1 NZ_CP027720:211364-211609 [Pseudomonas chlororaphis subsp. aureofaciens]
MQSVLADKAVSVSELKKNPSAVLNGAQGGAVAVLNHNRVMGYMVPADVFEAMMERLDDLELAEIVRARRHETPVPVNLDD
L

Download         Length: 246 bp

>AT99974 NZ_CP027720:211364-211609 [Pseudomonas chlororaphis subsp. aureofaciens]
ATGCAAAGCGTATTGGCTGATAAAGCTGTCAGCGTGTCTGAACTGAAAAAAAATCCTTCGGCTGTCCTGAACGGCGCACA
GGGTGGTGCGGTTGCGGTGCTCAATCACAACCGGGTCATGGGCTATATGGTCCCGGCCGACGTGTTTGAAGCCATGATGG
AGCGTCTTGACGATCTTGAACTGGCGGAGATTGTCCGTGCCCGTCGTCACGAGACCCCGGTCCCGGTAAATCTGGATGAC
TTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A285EY61

Antitoxin

Source ID Structure
AlphaFold DB A0A554PKE4

References