Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2303708..2304327 Replicon chromosome
Accession NZ_CP027715
Organism Pseudomonas chlororaphis subsp. aurantiaca strain M12

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag C4K24_RS10555 Protein ID WP_124308109.1
Coordinates 2304145..2304327 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag C4K24_RS10550 Protein ID WP_124308108.1
Coordinates 2303708..2304109 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4K24_RS10530 2299574..2301463 + 1890 WP_124308106.1 PAS domain S-box protein -
C4K24_RS10535 2301460..2302095 + 636 WP_101282090.1 response regulator transcription factor -
C4K24_RS10540 2302189..2302953 + 765 WP_103330830.1 hypothetical protein -
C4K24_RS10550 2303708..2304109 - 402 WP_124308108.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
C4K24_RS10555 2304145..2304327 - 183 WP_124308109.1 type II toxin-antitoxin system HicA family toxin Toxin
C4K24_RS10560 2304578..2305081 - 504 WP_124308110.1 zinc ribbon domain-containing protein -
C4K24_RS10570 2305689..2305970 - 282 WP_124308111.1 hypothetical protein -
C4K24_RS10575 2306394..2306750 - 357 WP_037004592.1 hypothetical protein -
C4K24_RS10585 2307115..2307396 - 282 WP_038631341.1 hypothetical protein -
C4K24_RS10590 2308305..2308697 + 393 WP_124308112.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6787.93 Da        Isoelectric Point: 10.9678

>T99946 WP_124308109.1 NZ_CP027715:c2304327-2304145 [Pseudomonas chlororaphis subsp. aurantiaca]
VQSRQLTKELEAAGWVLERVTGSHHLFKHPYRPETVPVPHPKKDLPRGTVRAIQKLAGLI

Download         Length: 183 bp

>T99946 NZ_CP027715:c2304327-2304145 [Pseudomonas chlororaphis subsp. aurantiaca]
GTGCAAAGCAGACAGTTGACCAAGGAGCTTGAAGCCGCAGGCTGGGTGCTGGAGCGCGTTACCGGCAGCCATCATCTGTT
CAAGCATCCCTACCGGCCCGAGACCGTTCCGGTGCCTCACCCGAAGAAGGATCTGCCACGGGGGACGGTCAGGGCCATCC
AGAAACTGGCCGGGCTGATATAG

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14578.60 Da        Isoelectric Point: 4.9093

>AT99946 WP_124308108.1 NZ_CP027715:c2304109-2303708 [Pseudomonas chlororaphis subsp. aurantiaca]
VQYPICIEWGDEHTATGIQIPDIPGAVTAGDTFEAAYSAAIEIAHVMLEKLAREGQAIPLPSPTGTHRANPDFEGMGWGM
LDIDITPYLGKTEKVNVTLPGYVIQRIDRFVREHNIKSRSSFLADAAMEKLGR

Download         Length: 402 bp

>AT99946 NZ_CP027715:c2304109-2303708 [Pseudomonas chlororaphis subsp. aurantiaca]
GTGCAATATCCCATCTGCATCGAGTGGGGCGACGAACACACTGCTACCGGCATCCAGATTCCTGACATTCCTGGCGCGGT
CACCGCCGGCGACACCTTCGAGGCCGCGTACAGCGCCGCCATCGAGATCGCCCACGTCATGCTCGAAAAACTGGCCCGCG
AGGGGCAAGCCATTCCCCTGCCCTCGCCCACCGGCACGCACCGCGCCAACCCCGACTTCGAAGGGATGGGCTGGGGCATG
CTGGATATCGATATCACGCCTTACCTGGGCAAAACCGAAAAGGTCAATGTGACCCTGCCGGGCTACGTGATTCAACGAAT
CGACCGCTTTGTGCGGGAGCACAACATCAAGAGCCGATCGTCTTTTCTGGCAGATGCGGCGATGGAAAAGCTGGGGCGTT
AA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References