Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 6537561..6539269 Replicon chromosome
Accession NZ_CP027714
Organism Pseudomonas chlororaphis strain ATCC 17415

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag C4K25_RS29695 Protein ID WP_114761240.1
Coordinates 6537561..6538439 (+) Length 293 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A5M7C4U8
Locus tag C4K25_RS29700 Protein ID WP_007928502.1
Coordinates 6538436..6539269 (+) Length 278 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4K25_RS29670 6533554..6534405 + 852 WP_114761242.1 ABC transporter ATP-binding protein -
C4K25_RS29675 6534445..6535434 + 990 WP_114761241.1 ABC transporter substrate-binding protein -
C4K25_RS29680 6535463..6536239 + 777 WP_007928506.1 ABC transporter permease -
C4K25_RS29685 6536239..6537003 + 765 WP_101336297.1 SDR family oxidoreductase -
C4K25_RS29690 6537017..6537556 + 540 WP_085532783.1 cupin domain-containing protein -
C4K25_RS29695 6537561..6538439 + 879 WP_114761240.1 alpha/beta hydrolase Toxin
C4K25_RS29700 6538436..6539269 + 834 WP_007928502.1 IclR family transcriptional regulator Antitoxin
C4K25_RS29705 6539271..6540068 + 798 WP_114761239.1 SDR family oxidoreductase -
C4K25_RS29710 6540061..6541743 + 1683 WP_114761268.1 thiamine pyrophosphate-binding protein -
C4K25_RS29715 6541754..6542557 + 804 WP_085532775.1 aspartate dehydrogenase -
C4K25_RS29720 6542569..6544065 + 1497 WP_114761238.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(45-276)

Antitoxin

Transcription regulator IclR, C-terminal

(136-256)


Sequences

Toxin        


Download         Length: 293 a.a.        Molecular weight: 31023.53 Da        Isoelectric Point: 8.0027

>T99942 WP_114761240.1 NZ_CP027714:6537561-6538439 [Pseudomonas chlororaphis]
MLPGLSQPVSTADLQARLTRDFAQRQVTVAGGRQALRECGAGPAIVLLHGIGSGAASWLQVAQQLAPQARVIAWDAPGYG
DSSPLESPAPKAEHYAARLVQMLDALDVEECVLVGHSLGALPALAFARSSQASRVSRLVLISPARGYGAPERGEQRQQVR
RQRLENLEHLGITGLAEQRSTHMLSPNAAPQALAWVRWNMARLNPAGYRQAIELLCGGDLLRHGQPGMPCEVHCGEADRI
TPAETCLTLAKALGASFNLIADAGHASPIEQPLVVAGRLAFAIKESLTGRTL

Download         Length: 879 bp

>T99942 NZ_CP027714:6537561-6538439 [Pseudomonas chlororaphis]
ATGTTGCCAGGCCTCTCTCAACCCGTATCGACGGCGGACCTCCAGGCCCGACTGACCCGGGACTTTGCCCAGCGCCAGGT
GACCGTGGCCGGCGGCCGGCAGGCCCTGCGCGAATGCGGCGCGGGCCCGGCGATCGTGCTGCTGCACGGCATCGGTTCCG
GGGCGGCGTCCTGGCTGCAGGTGGCGCAACAACTGGCGCCCCAGGCCCGGGTCATCGCCTGGGACGCGCCCGGCTACGGC
GATTCCAGCCCCCTGGAATCCCCCGCGCCCAAGGCCGAGCACTACGCCGCCCGCCTGGTGCAGATGCTCGATGCCCTGGA
CGTCGAGGAATGCGTGCTGGTGGGGCATTCCCTCGGCGCGCTGCCGGCCCTGGCCTTCGCTCGTAGTTCACAGGCGAGCC
GGGTGAGTCGCCTGGTACTGATCAGCCCGGCCCGGGGTTATGGCGCGCCGGAACGCGGCGAGCAGCGCCAGCAGGTGCGC
CGCCAGCGCCTGGAGAACCTGGAGCATCTGGGGATCACCGGCCTGGCCGAGCAACGCAGCACCCACATGCTCTCGCCCAA
CGCCGCGCCACAGGCCCTGGCCTGGGTGCGCTGGAACATGGCGCGGCTCAACCCCGCGGGTTATCGCCAGGCCATCGAGC
TGCTGTGCGGCGGCGACCTGCTGCGCCACGGCCAGCCCGGCATGCCCTGCGAAGTGCATTGCGGCGAGGCCGACCGCATC
ACCCCGGCCGAGACCTGCCTGACCCTGGCCAAGGCGCTGGGCGCCAGCTTCAACCTGATCGCCGACGCGGGCCATGCCAG
CCCCATCGAACAACCGCTGGTGGTCGCGGGCCGCCTGGCCTTTGCCATCAAAGAATCCCTGACAGGTAGAACCCTATGA

Antitoxin


Download         Length: 278 a.a.        Molecular weight: 30869.31 Da        Isoelectric Point: 6.6493

>AT99942 WP_007928502.1 NZ_CP027714:6538436-6539269 [Pseudomonas chlororaphis]
MNDSDPLKDAQDKYIVPGLERGLLLLCEFSRRNRTLTAPELARRLALPRSTIFRLLTTLETMGFVTRSGNEYRLGMSVLR
LGFEYLASLELTELGQPLLARLCDRLNYPSNLVVRDGRSIVYVAKVSPPSVFSNAVNVGTRLPAHATVLGRILLEDLSLA
ELRELYPEEHLEQYSHSTPKTVLELFDMVQADRQRGFISGEGFFESAISTVAAPVRDQSGRIAAALGVTIPTTQIGHVNF
EELLSQVRRSADELSRLLNYNGVAHDGQQRVTALMRD

Download         Length: 834 bp

>AT99942 NZ_CP027714:6538436-6539269 [Pseudomonas chlororaphis]
ATGAACGACTCCGATCCGCTGAAGGACGCTCAGGACAAATACATAGTGCCGGGCCTGGAGCGTGGCCTGTTGCTGCTCTG
CGAGTTCAGCCGGCGCAACCGCACCCTGACCGCGCCGGAACTGGCCCGCCGCCTGGCCCTGCCGCGCTCGACCATCTTTC
GCCTGCTCACCACCCTGGAAACCATGGGTTTCGTCACCCGCAGCGGCAACGAATACCGCCTCGGCATGTCGGTGCTGCGC
CTGGGCTTCGAATACCTGGCGTCGCTGGAGCTGACCGAGCTCGGCCAGCCGCTGCTGGCGCGCCTGTGCGACCGCCTCAA
CTACCCGAGCAACCTGGTGGTGCGCGACGGCCGCTCGATCGTCTACGTGGCCAAGGTCTCGCCGCCCTCGGTGTTCTCCA
ACGCGGTCAACGTCGGCACCCGCCTGCCGGCCCACGCCACGGTGCTGGGGCGCATCCTCCTGGAAGACCTGTCCCTGGCC
GAACTGCGCGAGCTGTACCCCGAAGAGCATCTGGAGCAGTACTCCCACAGCACGCCGAAAACCGTGCTGGAGCTGTTCGA
CATGGTCCAGGCCGACCGTCAGCGCGGCTTTATCAGCGGCGAAGGTTTCTTCGAATCGGCGATCTCCACGGTGGCCGCGC
CAGTGCGCGACCAGAGCGGGCGCATCGCCGCGGCCCTGGGCGTGACCATCCCCACCACGCAGATCGGCCACGTCAATTTC
GAGGAACTGCTGTCGCAGGTCCGCCGTAGCGCCGACGAGCTGTCACGCCTGCTCAACTACAACGGCGTGGCCCACGACGG
GCAACAGCGCGTGACCGCCTTGATGAGGGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A5M7C4U8

References