Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1544407..1545029 Replicon chromosome
Accession NZ_CP027712
Organism Pseudomonas chlororaphis subsp. chlororaphis strain DSM 50083

Toxin (Protein)


Gene name hicA Uniprot ID A0A285HEJ8
Locus tag C4K27_RS06975 Protein ID WP_053259927.1
Coordinates 1544847..1545029 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A285HET1
Locus tag C4K27_RS06970 Protein ID WP_009042564.1
Coordinates 1544407..1544814 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4K27_RS06950 1539582..1540250 - 669 WP_125737973.1 NAD(P)-binding domain-containing protein -
C4K27_RS06955 1540347..1541237 + 891 WP_053260051.1 LysR family transcriptional regulator -
C4K27_RS06960 1541475..1543253 + 1779 WP_053259925.1 sensor domain-containing phosphodiesterase -
C4K27_RS06965 1543287..1544201 - 915 WP_053259926.1 SGNH/GDSL hydrolase family protein -
C4K27_RS06970 1544407..1544814 - 408 WP_009042564.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
C4K27_RS06975 1544847..1545029 - 183 WP_053259927.1 type II toxin-antitoxin system HicA family toxin Toxin
C4K27_RS06980 1546093..1546809 + 717 WP_053259928.1 molecular chaperone -
C4K27_RS06985 1546920..1547879 + 960 WP_053259929.1 fimbrial protein -
C4K27_RS06990 1548003..1548563 + 561 WP_053259930.1 HipA domain-containing protein -
C4K27_RS06995 1548678..1549421 - 744 WP_053259931.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6873.18 Da        Isoelectric Point: 11.1084

>T99929 WP_053259927.1 NZ_CP027712:c1545029-1544847 [Pseudomonas chlororaphis subsp. chlororaphis]
VDSRYLIGQIVADGWYLVRVRGSHHHFKHPHKPGLVTVPHPKKDLLRKTAISILKQALLM

Download         Length: 183 bp

>T99929 NZ_CP027712:c1545029-1544847 [Pseudomonas chlororaphis subsp. chlororaphis]
GTGGACAGTCGGTATTTGATCGGCCAAATCGTCGCAGACGGTTGGTATCTGGTCAGGGTCAGGGGCAGTCACCACCATTT
CAAGCATCCCCATAAACCGGGGCTGGTGACCGTTCCCCATCCCAAAAAGGACCTGCTGAGAAAAACCGCCATCAGCATTC
TGAAACAGGCGCTGCTCATGTGA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14698.72 Da        Isoelectric Point: 4.5911

>AT99929 WP_009042564.1 NZ_CP027712:c1544814-1544407 [Pseudomonas chlororaphis subsp. chlororaphis]
MLYPIAISMGDDEHAWGVEVPDIPGCFSAGDDLDDAMAMAREAIEGHFEILAEDGAPIPHANKVTLHAANPRYAGCTWAL
IDIDVTKYLGKAQKLNITLPGYLLNRIDEYVLHHPEAKSRSGFLASAALKVLQQD

Download         Length: 408 bp

>AT99929 NZ_CP027712:c1544814-1544407 [Pseudomonas chlororaphis subsp. chlororaphis]
ATGCTTTACCCGATTGCAATTTCAATGGGCGATGACGAACACGCCTGGGGGGTGGAAGTCCCCGATATTCCTGGCTGTTT
CTCGGCCGGCGACGACCTCGACGACGCCATGGCCATGGCCCGCGAAGCCATCGAAGGGCACTTCGAGATTCTCGCCGAAG
ACGGTGCCCCCATCCCGCACGCCAACAAGGTCACCCTGCACGCGGCCAACCCCCGGTACGCAGGCTGCACCTGGGCGCTG
ATCGACATCGATGTCACCAAGTACCTGGGCAAGGCGCAGAAGCTCAACATCACCCTGCCCGGCTACTTGCTGAACCGCAT
CGACGAATACGTGCTGCATCACCCGGAAGCCAAGAGCCGCTCGGGCTTTCTCGCTTCGGCTGCACTGAAGGTATTGCAGC
AAGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A285HEJ8

Antitoxin

Source ID Structure
AlphaFold DB A0A285HET1

References