Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2362959..2363578 Replicon chromosome
Accession NZ_CP027711
Organism Pseudomonas chlororaphis subsp. piscium strain ChPhzTR44

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag C4K28_RS10730 Protein ID WP_053278351.1
Coordinates 2363396..2363578 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag C4K28_RS10725 Protein ID WP_124373023.1
Coordinates 2362959..2363360 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4K28_RS10710 2359053..2360942 + 1890 WP_124302676.1 PAS domain S-box protein -
C4K28_RS10715 2360939..2361574 + 636 WP_053260452.1 response regulator transcription factor -
C4K28_RS10720 2361668..2362417 + 750 WP_124373022.1 hypothetical protein -
C4K28_RS10725 2362959..2363360 - 402 WP_124373023.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
C4K28_RS10730 2363396..2363578 - 183 WP_053278351.1 type II toxin-antitoxin system HicA family toxin Toxin
C4K28_RS10735 2363829..2364332 - 504 WP_124339345.1 zinc ribbon domain-containing protein -
C4K28_RS10740 2364949..2365230 - 282 WP_124373024.1 hypothetical protein -
C4K28_RS10745 2365815..2366399 + 585 WP_124373025.1 hypothetical protein -
C4K28_RS10750 2366486..2367583 + 1098 WP_124373026.1 hypothetical protein -
C4K28_RS10755 2367808..2368356 - 549 WP_124373027.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6799.98 Da        Isoelectric Point: 10.9678

>T99923 WP_053278351.1 NZ_CP027711:c2363578-2363396 [Pseudomonas chlororaphis subsp. piscium]
VQSRQLIKELEAAGWVLERVTGSHHLFKHPYRPETVPVPHPKKDLPRGTVRAIQKLAGLL

Download         Length: 183 bp

>T99923 NZ_CP027711:c2363578-2363396 [Pseudomonas chlororaphis subsp. piscium]
GTGCAAAGCAGACAGCTGATCAAGGAGCTTGAAGCCGCAGGCTGGGTGCTGGAGCGCGTTACCGGCAGCCATCATCTGTT
CAAGCATCCCTACCGGCCCGAGACCGTTCCGGTGCCTCACCCGAAGAAGGATCTGCCACGGGGGACGGTCAGGGCCATCC
AGAAACTGGCCGGGCTGTTATAG

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14607.59 Da        Isoelectric Point: 4.6017

>AT99923 WP_124373023.1 NZ_CP027711:c2363360-2362959 [Pseudomonas chlororaphis subsp. piscium]
VQYPICIEWGDEHTATGIQIPDIPGAVTAGDTFEAAYSAAIEIVHVMLEELAREGQAIPLPSPTGTHRANPDFEGMGWGM
LDIDITPYLGKTEKVNVTLPGYVIQRIDRFVREHNIKSRSSFLADAAMEKLGR

Download         Length: 402 bp

>AT99923 NZ_CP027711:c2363360-2362959 [Pseudomonas chlororaphis subsp. piscium]
GTGCAATATCCCATCTGCATCGAGTGGGGTGACGAGCACACTGCTACCGGCATCCAGATTCCTGATATTCCTGGCGCGGT
CACCGCCGGCGACACCTTCGAGGCCGCGTACAGCGCCGCCATCGAGATTGTCCACGTCATGCTCGAAGAACTGGCCCGTG
AGGGGCAAGCCATTCCCCTGCCCTCGCCCACCGGCACACACCGCGCCAACCCCGACTTCGAGGGGATGGGCTGGGGCATG
CTGGATATCGATATCACGCCTTACCTGGGCAAGACCGAGAAGGTCAATGTGACCCTGCCGGGGTATGTGATTCAGCGAAT
TGACCGCTTTGTGCGGGAGCACAACATCAAGAGCCGGTCGTCTTTTCTGGCGGATGCGGCGATGGAAAAGCTGGGGCGTT
AA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References