Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 2429512..2430097 Replicon chromosome
Accession NZ_CP027710
Organism Pseudomonas chlororaphis subsp. piscium strain SLPH10

Toxin (Protein)


Gene name PumA Uniprot ID A0A3G7C0N8
Locus tag C4K35_RS11130 Protein ID WP_025804099.1
Coordinates 2429804..2430097 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A3G7CJP2
Locus tag C4K35_RS11125 Protein ID WP_025804100.1
Coordinates 2429512..2429802 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4K35_RS11110 2424837..2427317 + 2481 WP_063430875.1 FtsX-like permease family protein -
C4K35_RS11115 2427307..2428383 + 1077 WP_025804102.1 iron ABC transporter permease -
C4K35_RS11120 2428511..2429098 + 588 WP_025804101.1 hypothetical protein -
C4K35_RS11125 2429512..2429802 - 291 WP_025804100.1 putative addiction module antidote protein Antitoxin
C4K35_RS11130 2429804..2430097 - 294 WP_025804099.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C4K35_RS11135 2430333..2431727 - 1395 WP_124302682.1 VOC family protein -
C4K35_RS11140 2431990..2433114 + 1125 WP_051519186.1 diguanylate cyclase -
C4K35_RS11145 2433208..2434452 + 1245 WP_025804096.1 M20/M25/M40 family metallo-hydrolase -
C4K35_RS11150 2434653..2435051 + 399 WP_025804095.1 carboxymuconolactone decarboxylase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-96)

Antitoxin

Uncharacterized protein HI1420

(9-91)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10837.49 Da        Isoelectric Point: 10.7289

>T99918 WP_025804099.1 NZ_CP027710:c2430097-2429804 [Pseudomonas chlororaphis subsp. piscium]
MEYEILQTTVFAQWHTRLRDLRARIAIARRIERASAGNLGDVKNLGGGLSEMRVNRGAGYRIYFTVRGNTLIVLLLGGDK
STQPADICQARSLAKEF

Download         Length: 294 bp

>T99918 NZ_CP027710:c2430097-2429804 [Pseudomonas chlororaphis subsp. piscium]
ATGGAATACGAGATCCTGCAGACGACCGTCTTTGCCCAATGGCACACCAGACTACGGGACCTGCGCGCCAGGATAGCCAT
CGCTCGGCGTATCGAGCGGGCTTCGGCGGGCAACCTGGGCGATGTGAAAAACCTCGGCGGCGGTCTCTCGGAAATGCGCG
TGAATAGGGGCGCCGGCTACCGCATCTATTTCACGGTTCGCGGCAACACCCTCATCGTCCTGCTGCTGGGCGGCGACAAG
TCCACCCAGCCTGCCGATATCTGCCAGGCCCGTTCCCTGGCCAAGGAGTTCTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10249.81 Da        Isoelectric Point: 8.0096

>AT99918 WP_025804100.1 NZ_CP027710:c2429802-2429512 [Pseudomonas chlororaphis subsp. piscium]
MSDTLVPFDIATLLDSDQAISEYLSQVLADGDTDELIRALGHVARARGMTQIAKATGQGRASLYKAFAPGAKPRFDTVVK
VMRALGLQLCTTVPRG

Download         Length: 291 bp

>AT99918 NZ_CP027710:c2429802-2429512 [Pseudomonas chlororaphis subsp. piscium]
ATGTCCGACACACTGGTTCCCTTCGACATCGCCACCCTGCTCGACAGCGACCAGGCGATCAGCGAATACCTGTCCCAGGT
CCTGGCCGATGGCGATACCGATGAACTGATCCGCGCCCTGGGCCATGTCGCCAGGGCCCGGGGCATGACGCAGATTGCCA
AGGCCACCGGCCAGGGCCGGGCCAGCCTCTACAAGGCCTTTGCCCCGGGCGCCAAGCCGCGCTTCGATACCGTGGTCAAG
GTCATGCGCGCGCTGGGCCTGCAGTTGTGCACCACAGTGCCCCGAGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G7C0N8

Antitoxin

Source ID Structure
AlphaFold DB A0A3G7CJP2

References