Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2416110..2416729 Replicon chromosome
Accession NZ_CP027710
Organism Pseudomonas chlororaphis subsp. piscium strain SLPH10

Toxin (Protein)


Gene name hicA Uniprot ID A0A3G7DMG3
Locus tag C4K35_RS11070 Protein ID WP_009048155.1
Coordinates 2416547..2416729 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A285IZU0
Locus tag C4K35_RS11065 Protein ID WP_007923747.1
Coordinates 2416110..2416511 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4K35_RS11050 2412179..2414068 + 1890 WP_124302676.1 PAS domain S-box protein -
C4K35_RS11055 2414065..2414700 + 636 WP_053260452.1 response regulator transcription factor -
C4K35_RS11060 2414794..2415543 + 750 WP_124302677.1 hypothetical protein -
C4K35_RS11065 2416110..2416511 - 402 WP_007923747.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
C4K35_RS11070 2416547..2416729 - 183 WP_009048155.1 type II toxin-antitoxin system HicA family toxin Toxin
C4K35_RS11075 2417093..2417374 - 282 WP_124302678.1 hypothetical protein -
C4K35_RS11080 2418687..2420453 + 1767 WP_206429416.1 AIPR family protein -
C4K35_RS11085 2420751..2421299 - 549 WP_124302680.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6799.98 Da        Isoelectric Point: 10.9678

>T99917 WP_009048155.1 NZ_CP027710:c2416729-2416547 [Pseudomonas chlororaphis subsp. piscium]
VQSRQLIKELEAAGWVLERVTGSHHLFKHPYRPETVPVPHPKKDLPRGTVRAIQKLAGLI

Download         Length: 183 bp

>T99917 NZ_CP027710:c2416729-2416547 [Pseudomonas chlororaphis subsp. piscium]
GTGCAAAGCAGACAGTTGATCAAGGAGCTTGAAGCCGCAGGCTGGGTGCTGGAGCGCGTTACCGGTAGCCATCATCTGTT
CAAGCATCCCTACCGGCCCGAGACCGTTCCGGTGCCTCACCCGAAGAAGGATCTGCCACGGGGGACGGTCAGGGCCATCC
AGAAACTGGCCGGGCTGATATAG

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14579.54 Da        Isoelectric Point: 4.6017

>AT99917 WP_007923747.1 NZ_CP027710:c2416511-2416110 [Pseudomonas chlororaphis subsp. piscium]
VQYPICIEWGDEHTATGIQIPDIPGAVTAGDTFEAAYSAAIEIAHVMLEELAREGQAIPLPSPTGTHRANPDFEGMGWGM
LDIDITPYLGKTEKVNVTLPGYVIQRIDRFVREHNIKSRSSFLADAAMEKLGR

Download         Length: 402 bp

>AT99917 NZ_CP027710:c2416511-2416110 [Pseudomonas chlororaphis subsp. piscium]
GTGCAATATCCCATCTGCATCGAGTGGGGCGACGAGCACACTGCTACCGGCATCCAGATTCCTGACATTCCGGGCGCGGT
AACCGCCGGCGACACCTTCGAGGCCGCGTATAGCGCCGCCATCGAGATCGCCCACGTCATGCTCGAAGAGCTGGCCCGTG
AGGGGCAAGCCATTCCCCTGCCCTCGCCCACCGGCACGCACCGCGCCAACCCCGACTTCGAGGGGATGGGCTGGGGCATG
CTGGATATCGATATCACGCCTTACCTGGGCAAAACCGAGAAGGTCAATGTGACCCTGCCGGGTTACGTGATTCAACGAAT
CGACCGCTTTGTGCGGGAGCACAACATCAAGAGCCGATCGTCATTCCTGGCGGATGCGGCGATGGAAAAGCTGGGGCGTT
AA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G7DMG3

Antitoxin

Source ID Structure
AlphaFold DB A0A285IZU0

References