Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1564406..1565028 Replicon chromosome
Accession NZ_CP027710
Organism Pseudomonas chlororaphis subsp. piscium strain SLPH10

Toxin (Protein)


Gene name hicA Uniprot ID A0A2N8AR08
Locus tag C4K35_RS07190 Protein ID WP_007929414.1
Coordinates 1564846..1565028 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A2N8AQX2
Locus tag C4K35_RS07185 Protein ID WP_063429381.1
Coordinates 1564406..1564813 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4K35_RS07165 1559709..1560602 + 894 WP_173678573.1 LysR family transcriptional regulator -
C4K35_RS07170 1560838..1562616 + 1779 WP_063428837.1 GGDEF and EAL domain-containing protein -
C4K35_RS07175 1562650..1563564 - 915 WP_063428839.1 SGNH/GDSL hydrolase family protein -
C4K35_RS07180 1563694..1564160 - 467 Protein_1396 GAF domain-containing protein -
C4K35_RS07185 1564406..1564813 - 408 WP_063429381.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
C4K35_RS07190 1564846..1565028 - 183 WP_007929414.1 type II toxin-antitoxin system HicA family toxin Toxin
C4K35_RS07200 1565747..1566631 - 885 WP_009047472.1 alpha/beta hydrolase -
C4K35_RS07205 1566983..1567675 - 693 WP_025804997.1 16S rRNA pseudouridine(516) synthase -
C4K35_RS07210 1567709..1567942 - 234 WP_036997815.1 cysteine-rich CWC family protein -
C4K35_RS07215 1567935..1569422 - 1488 WP_025804999.1 sensor domain-containing diguanylate cyclase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6850.15 Da        Isoelectric Point: 11.6709

>T99916 WP_007929414.1 NZ_CP027710:c1565028-1564846 [Pseudomonas chlororaphis subsp. piscium]
VNSRYLIGQIVADGWYLVRVRGSHHHFRHPSKPGLVTVPHPKKDLLRKTAISILKQALLM

Download         Length: 183 bp

>T99916 NZ_CP027710:c1565028-1564846 [Pseudomonas chlororaphis subsp. piscium]
GTGAACAGTCGGTATTTGATCGGCCAAATCGTCGCAGACGGTTGGTATCTGGTCAGGGTCAGAGGCAGTCACCACCATTT
CAGGCACCCCAGTAAACCGGGGCTGGTGACAGTTCCACATCCCAAAAAGGACCTGCTGAGAAAAACCGCCATCAGCATTC
TGAAACAGGCGCTGCTCATGTGA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14604.60 Da        Isoelectric Point: 4.3638

>AT99916 WP_063429381.1 NZ_CP027710:c1564813-1564406 [Pseudomonas chlororaphis subsp. piscium]
MLYPIAISMGDDEHAWGVEVPDIPGCFSAGDDLDDAMAMAREAIEGHFEILAEDGAAIPPANKVTLHAANPQYAGCTWAL
IDIDVTKYLGKAQKLNITLPGYLLNRIDEYVLHHPEAKSRSGFLASAALKVLQQD

Download         Length: 408 bp

>AT99916 NZ_CP027710:c1564813-1564406 [Pseudomonas chlororaphis subsp. piscium]
ATGCTTTACCCGATTGCAATTTCAATGGGCGATGACGAACACGCCTGGGGCGTGGAAGTCCCCGACATTCCTGGCTGTTT
CTCGGCCGGCGACGACCTCGACGACGCCATGGCCATGGCCCGCGAAGCCATCGAAGGGCACTTCGAGATTCTCGCCGAAG
ACGGCGCCGCCATCCCACCCGCCAACAAGGTCACCCTGCACGCGGCCAACCCTCAGTATGCAGGCTGCACCTGGGCGCTG
ATCGACATCGATGTCACCAAGTACCTGGGCAAGGCGCAGAAGCTCAACATCACCCTGCCCGGCTACCTGCTGAACCGCAT
CGACGAATACGTGCTGCATCACCCGGAAGCAAAAAGCCGCTCGGGTTTTCTCGCTTCGGCTGCATTGAAGGTATTGCAGC
AGGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2N8AR08

Antitoxin

Source ID Structure
AlphaFold DB A0A2N8AQX2

References