Detailed information of TA system TA099910

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1550488..1551110
• Replicon: chromosome
• Accession: NZ_CP027709
• Organism: Pseudomonas chlororaphis subsp. piscium strain ATCC 17809

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: C4K36_RS07110
• Protein ID: WP_106696706.1
• Coordinates: 1550928..1551110 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: C4K36_RS07105
• Protein ID: WP_106698998.1
• Coordinates: 1550488..1550895 (-)
• Length: 136 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C4K36_RS07085	1545790..1546683	+	894	WP_173678573.1	LysR family transcriptional regulator	-
C4K36_RS07090	1546919..1548697	+	1779	WP_124323664.1	GGDEF and EAL domain-containing protein	-
C4K36_RS07095	1548731..1549645	-	915	WP_124323665.1	SGNH/GDSL hydrolase family protein	-
C4K36_RS07100	1549775..1550242	-	468	WP_106696705.1	GAF domain-containing protein	-
C4K36_RS07105	1550488..1550895	-	408	WP_106698998.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
C4K36_RS07110	1550928..1551110	-	183	WP_106696706.1	type II toxin-antitoxin system HicA family toxin	Toxin
C4K36_RS07120	1551829..1552713	-	885	WP_009047472.1	alpha/beta hydrolase	-
C4K36_RS07125	1553065..1553757	-	693	WP_025804997.1	16S rRNA pseudouridine(516) synthase	-
C4K36_RS07130	1553791..1554024	-	234	WP_106696707.1	cysteine-rich CWC family protein	-
C4K36_RS07135	1554017..1555504	-	1488	WP_106696708.1	sensor domain-containing diguanylate cyclase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-57)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6810.12 Da
• Isoelectric Point: 11.6709

>T99910 WP_106696706.1 NZ_CP027709:c1551110-1550928 [Pseudomonas chlororaphis subsp. piscium]
VNSRYLIGQIVADGWYLVRVRGSHHPFRHPSKPGLVTVPHPKKDLLRKTAISILKQALLM

Nucleotide

• Length: 183 bp

>T99910 NZ_CP027709:c1551110-1550928 [Pseudomonas chlororaphis subsp. piscium]
GTGAACAGTCGGTATTTGATCGGCCAAATCGTCGCAGACGGTTGGTATCTGGTCAGGGTCAGAGGCAGTCACCACCCTTT
CAGGCACCCCAGTAAACCGGGGCTGGTGACAGTTCCACATCCCAAAAAGGACCTGCTGAGAAAAACCGCCATCAGCATTC
TGAAACAGGCGCTGCTCATGTGA

Antitoxin

Protein

• Length: 136 a.a.
• Molecular weight: 14657.65 Da
• Isoelectric Point: 4.4710

>AT99910 WP_106698998.1 NZ_CP027709:c1550895-1550488 [Pseudomonas chlororaphis subsp. piscium]
MLYPIAISMGDDEHAWGVEVPDIPGCFSAGDDLDDAMAMAREAIEGHFEILAEDGAAIPPANKVTLHAANPQYAGRTWAL
IDIDVTKYLGKAQKLNITLPGYLLNRIDEYVLHHPEAKSRSGFLASAALKVLQQD

Nucleotide

• Length: 408 bp

>AT99910 NZ_CP027709:c1550895-1550488 [Pseudomonas chlororaphis subsp. piscium]
ATGCTTTACCCGATTGCAATTTCAATGGGCGATGACGAACACGCCTGGGGCGTGGAAGTCCCCGACATTCCTGGCTGTTT
CTCGGCCGGCGACGACCTCGACGACGCCATGGCCATGGCCCGCGAAGCCATCGAAGGGCACTTCGAGATTCTCGCCGAAG
ACGGTGCCGCCATCCCGCCCGCCAACAAGGTCACCCTGCACGCGGCCAACCCTCAGTACGCAGGCCGCACCTGGGCGCTG
ATCGACATCGATGTCACCAAGTACCTGGGCAAGGCGCAGAAGCTCAACATCACCCTGCCCGGCTACCTGCTGAACCGCAT
CGACGAATACGTGCTGCATCACCCGGAAGCAAAAAGCCGCTCGGGTTTTCTCGCTTCGGCTGCATTGAAGGTATTGCAGC
AAGACTGA