Detailed information of TA system TA099907

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 310968..311581
• Replicon: chromosome
• Accession: NZ_CP027709
• Organism: Pseudomonas chlororaphis subsp. piscium strain ATCC 17809

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A285EYZ4
• Locus tag: C4K36_RS01355
• Protein ID: WP_009041685.1
• Coordinates: 310968..311150 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: C4K36_RS01360
• Protein ID: WP_025808441.1
• Coordinates: 311180..311581 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C4K36_RS01330	306142..308106	+	1965	WP_164486059.1	choline transporter BetT	-
C4K36_RS01335	308227..308484	-	258	WP_025808445.1	hypothetical protein	-
C4K36_RS01340	308538..309026	-	489	WP_124323274.1	DoxX family membrane protein	-
C4K36_RS01345	309083..309823	-	741	WP_124323275.1	SDR family oxidoreductase	-
C4K36_RS01350	309953..310843	+	891	WP_124323276.1	LysR family transcriptional regulator	-
C4K36_RS01355	310968..311150	+	183	WP_009041685.1	type II toxin-antitoxin system HicA family toxin	Toxin
C4K36_RS01360	311180..311581	+	402	WP_025808441.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
C4K36_RS01365	312172..313209	+	1038	WP_124323277.1	L-glyceraldehyde 3-phosphate reductase	-
C4K36_RS01370	313339..313767	-	429	WP_124323278.1	type II toxin-antitoxin system VapC family toxin	-
C4K36_RS01375	313764..314009	-	246	WP_009046453.1	plasmid stabilization protein	-
C4K36_RS01380	314149..314988	-	840	WP_124323279.1	taurine dioxygenase	-
C4K36_RS01385	315226..316065	-	840	WP_124323280.1	taurine ABC transporter permease TauC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6933.08 Da
• Isoelectric Point: 10.4588

>T99907 WP_009041685.1 NZ_CP027709:310968-311150 [Pseudomonas chlororaphis subsp. piscium]
MRSRELIRMIEEDGWYLIAVKGSHHQYKHLHKPGRVTIPHPDADLPRGTIHSILKQAGLK

Nucleotide

• Length: 183 bp

>T99907 NZ_CP027709:310968-311150 [Pseudomonas chlororaphis subsp. piscium]
ATGCGCAGTCGGGAACTGATCAGGATGATCGAGGAGGACGGGTGGTATCTGATCGCGGTCAAAGGCAGTCATCACCAGTA
CAAGCATCTGCACAAGCCGGGGCGGGTCACTATCCCTCACCCGGATGCGGATCTGCCCAGGGGCACGATCCACAGCATCT
TGAAACAGGCGGGCCTGAAATGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14568.38 Da
• Isoelectric Point: 4.9036

>AT99907 WP_025808441.1 NZ_CP027709:311180-311581 [Pseudomonas chlororaphis subsp. piscium]
MKFPVVLHKDADSGYGVIVPDVPGCFSAGHTAAQAFENVKEALSLHYEGLVADGEPLPQVHEVDVHIDNPDYAGGVWGVV
DFDITPYFGKAVRFNATLPEQLLERIDQTVKRDQRYRSRSGFLAAAALRELSA

Nucleotide

• Length: 402 bp

>AT99907 NZ_CP027709:311180-311581 [Pseudomonas chlororaphis subsp. piscium]
ATGAAATTCCCGGTCGTGCTGCACAAGGATGCCGACTCCGGATATGGAGTGATCGTCCCCGATGTGCCGGGCTGTTTTTC
CGCCGGTCATACCGCTGCGCAAGCCTTCGAGAATGTGAAAGAAGCCTTGTCGCTGCACTACGAAGGCCTGGTCGCCGATG
GTGAGCCGCTGCCCCAGGTACATGAGGTTGATGTGCATATCGACAATCCCGATTACGCCGGCGGTGTATGGGGGGTGGTC
GATTTCGATATCACGCCTTACTTCGGCAAGGCGGTGCGTTTTAATGCGACGTTGCCGGAGCAACTGTTGGAGCGCATCGA
CCAGACAGTGAAGCGCGACCAGCGCTACCGTTCGCGCTCGGGTTTTCTCGCCGCGGCGGCACTACGCGAGCTCTCCGCCT
AG

Structures

Toxin

• AlphaFold DB: A0A285EYZ4