Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 2394877..2395462 Replicon chromosome
Accession NZ_CP027708
Organism Pseudomonas chlororaphis subsp. piscium strain ATCC 17411

Toxin (Protein)


Gene name PumA Uniprot ID A0A3G7C0N8
Locus tag C4K37_RS10920 Protein ID WP_025804099.1
Coordinates 2395169..2395462 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A3G7CJP2
Locus tag C4K37_RS10915 Protein ID WP_025804100.1
Coordinates 2394877..2395167 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4K37_RS10900 2390202..2392682 + 2481 WP_124325843.1 FtsX-like permease family protein -
C4K37_RS10905 2392672..2393748 + 1077 WP_124323951.1 iron ABC transporter permease -
C4K37_RS10910 2393876..2394463 + 588 WP_063429489.1 hypothetical protein -
C4K37_RS10915 2394877..2395167 - 291 WP_025804100.1 putative addiction module antidote protein Antitoxin
C4K37_RS10920 2395169..2395462 - 294 WP_025804099.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C4K37_RS10925 2395698..2397092 - 1395 WP_124323952.1 VOC family protein -
C4K37_RS10930 2397355..2398479 + 1125 WP_124323953.1 diguanylate cyclase -
C4K37_RS10935 2398573..2399817 + 1245 WP_124323954.1 M20/M25/M40 family metallo-hydrolase -
C4K37_RS10940 2400030..2400428 + 399 WP_016702749.1 carboxymuconolactone decarboxylase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-96)

Antitoxin

Uncharacterized protein HI1420

(9-91)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10837.49 Da        Isoelectric Point: 10.7289

>T99905 WP_025804099.1 NZ_CP027708:c2395462-2395169 [Pseudomonas chlororaphis subsp. piscium]
MEYEILQTTVFAQWHTRLRDLRARIAIARRIERASAGNLGDVKNLGGGLSEMRVNRGAGYRIYFTVRGNTLIVLLLGGDK
STQPADICQARSLAKEF

Download         Length: 294 bp

>T99905 NZ_CP027708:c2395462-2395169 [Pseudomonas chlororaphis subsp. piscium]
ATGGAATACGAGATCCTGCAGACGACCGTCTTTGCCCAATGGCACACCAGACTACGGGACCTGCGCGCCAGGATAGCCAT
CGCTCGGCGTATCGAGCGGGCTTCGGCGGGCAACCTGGGCGATGTGAAAAACCTCGGCGGCGGTCTCTCGGAAATGCGCG
TGAATAGGGGCGCCGGCTACCGCATCTATTTCACGGTTCGCGGCAACACCCTCATCGTCCTGCTGCTGGGCGGCGACAAG
TCCACCCAGCCTGCCGATATCTGCCAGGCCCGTTCCCTGGCCAAGGAGTTCTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10249.81 Da        Isoelectric Point: 8.0096

>AT99905 WP_025804100.1 NZ_CP027708:c2395167-2394877 [Pseudomonas chlororaphis subsp. piscium]
MSDTLVPFDIATLLDSDQAISEYLSQVLADGDTDELIRALGHVARARGMTQIAKATGQGRASLYKAFAPGAKPRFDTVVK
VMRALGLQLCTTVPRG

Download         Length: 291 bp

>AT99905 NZ_CP027708:c2395167-2394877 [Pseudomonas chlororaphis subsp. piscium]
ATGTCCGACACACTGGTTCCCTTCGACATCGCCACCCTGCTCGACAGCGACCAGGCGATCAGCGAATACCTGTCCCAGGT
CCTGGCCGATGGCGATACCGATGAACTGATCCGCGCCCTGGGCCATGTCGCCAGGGCCCGGGGCATGACGCAGATTGCCA
AGGCCACCGGCCAGGGCCGGGCCAGCCTCTACAAGGCCTTTGCCCCGGGCGCCAAGCCGCGCTTCGATACCGTGGTCAAG
GTCATGCGCGCGCTGGGCCTGCAGTTGTGCACCACAGTGCCCCGAGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G7C0N8

Antitoxin

Source ID Structure
AlphaFold DB A0A3G7CJP2

References