Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2380206..2380825 Replicon chromosome
Accession NZ_CP027708
Organism Pseudomonas chlororaphis subsp. piscium strain ATCC 17411

Toxin (Protein)


Gene name hicA Uniprot ID A0A3G7DMG3
Locus tag C4K37_RS10860 Protein ID WP_009048155.1
Coordinates 2380643..2380825 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A285IZU0
Locus tag C4K37_RS10855 Protein ID WP_007923747.1
Coordinates 2380206..2380607 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4K37_RS10840 2376276..2378165 + 1890 WP_124304744.1 PAS domain S-box protein -
C4K37_RS10845 2378162..2378797 + 636 WP_124304745.1 response regulator transcription factor -
C4K37_RS10850 2378891..2379640 + 750 WP_124304746.1 hypothetical protein -
C4K37_RS10855 2380206..2380607 - 402 WP_007923747.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
C4K37_RS10860 2380643..2380825 - 183 WP_009048155.1 type II toxin-antitoxin system HicA family toxin Toxin
C4K37_RS10865 2381117..2381398 - 282 WP_124304747.1 hypothetical protein -
C4K37_RS10870 2382042..2384201 - 2160 WP_164486009.1 AAA family ATPase -
C4K37_RS10875 2384542..2385090 - 549 WP_124304749.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6799.98 Da        Isoelectric Point: 10.9678

>T99904 WP_009048155.1 NZ_CP027708:c2380825-2380643 [Pseudomonas chlororaphis subsp. piscium]
VQSRQLIKELEAAGWVLERVTGSHHLFKHPYRPETVPVPHPKKDLPRGTVRAIQKLAGLI

Download         Length: 183 bp

>T99904 NZ_CP027708:c2380825-2380643 [Pseudomonas chlororaphis subsp. piscium]
GTGCAAAGCAGACAGTTGATCAAGGAGCTTGAAGCCGCAGGCTGGGTGCTGGAGCGCGTTACCGGTAGCCATCATCTGTT
CAAGCATCCCTACCGGCCCGAGACCGTTCCGGTGCCTCACCCGAAGAAAGATCTGCCACGGGGGACGGTCAGGGCCATCC
AGAAACTGGCCGGGCTGATATAG

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14579.54 Da        Isoelectric Point: 4.6017

>AT99904 WP_007923747.1 NZ_CP027708:c2380607-2380206 [Pseudomonas chlororaphis subsp. piscium]
VQYPICIEWGDEHTATGIQIPDIPGAVTAGDTFEAAYSAAIEIAHVMLEELAREGQAIPLPSPTGTHRANPDFEGMGWGM
LDIDITPYLGKTEKVNVTLPGYVIQRIDRFVREHNIKSRSSFLADAAMEKLGR

Download         Length: 402 bp

>AT99904 NZ_CP027708:c2380607-2380206 [Pseudomonas chlororaphis subsp. piscium]
GTGCAATATCCCATCTGCATCGAGTGGGGCGACGAGCACACTGCTACCGGCATCCAGATTCCTGACATTCCGGGCGCGGT
AACCGCCGGCGACACCTTCGAGGCCGCGTATAGCGCCGCCATCGAGATCGCCCACGTCATGCTCGAAGAGCTGGCCCGTG
AGGGGCAAGCCATTCCCCTGCCCTCGCCCACCGGCACGCACCGCGCCAACCCCGACTTCGAGGGGATGGGCTGGGGCATG
CTGGATATCGATATCACGCCTTACCTGGGCAAAACCGAGAAGGTCAATGTGACCCTGCCGGGTTACGTGATTCAACGAAT
CGACCGCTTTGTGCGGGAGCACAACATCAAGAGCCGATCGTCATTCCTGGCGGATGCGGCGATGGAAAAGCTGGGGCGTT
AA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G7DMG3

Antitoxin

Source ID Structure
AlphaFold DB A0A285IZU0

References