Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1550478..1551100 Replicon chromosome
Accession NZ_CP027708
Organism Pseudomonas chlororaphis subsp. piscium strain ATCC 17411

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag C4K37_RS07110 Protein ID WP_106696706.1
Coordinates 1550918..1551100 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag C4K37_RS07105 Protein ID WP_106698998.1
Coordinates 1550478..1550885 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4K37_RS07085 1545780..1546673 + 894 WP_173678573.1 LysR family transcriptional regulator -
C4K37_RS07090 1546909..1548687 + 1779 WP_124323664.1 GGDEF and EAL domain-containing protein -
C4K37_RS07095 1548721..1549635 - 915 WP_124323665.1 SGNH/GDSL hydrolase family protein -
C4K37_RS07100 1549765..1550232 - 468 WP_106696705.1 GAF domain-containing protein -
C4K37_RS07105 1550478..1550885 - 408 WP_106698998.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
C4K37_RS07110 1550918..1551100 - 183 WP_106696706.1 type II toxin-antitoxin system HicA family toxin Toxin
C4K37_RS07120 1551819..1552703 - 885 WP_009047472.1 alpha/beta hydrolase -
C4K37_RS07125 1553055..1553747 - 693 WP_025804997.1 16S rRNA pseudouridine(516) synthase -
C4K37_RS07130 1553781..1554014 - 234 WP_106696707.1 cysteine-rich CWC family protein -
C4K37_RS07135 1554007..1555494 - 1488 WP_106696708.1 sensor domain-containing diguanylate cyclase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6810.12 Da        Isoelectric Point: 11.6709

>T99903 WP_106696706.1 NZ_CP027708:c1551100-1550918 [Pseudomonas chlororaphis subsp. piscium]
VNSRYLIGQIVADGWYLVRVRGSHHPFRHPSKPGLVTVPHPKKDLLRKTAISILKQALLM

Download         Length: 183 bp

>T99903 NZ_CP027708:c1551100-1550918 [Pseudomonas chlororaphis subsp. piscium]
GTGAACAGTCGGTATTTGATCGGCCAAATCGTCGCAGACGGTTGGTATCTGGTCAGGGTCAGAGGCAGTCACCACCCTTT
CAGGCACCCCAGTAAACCGGGGCTGGTGACAGTTCCACATCCCAAAAAGGACCTGCTGAGAAAAACCGCCATCAGCATTC
TGAAACAGGCGCTGCTCATGTGA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14657.65 Da        Isoelectric Point: 4.4710

>AT99903 WP_106698998.1 NZ_CP027708:c1550885-1550478 [Pseudomonas chlororaphis subsp. piscium]
MLYPIAISMGDDEHAWGVEVPDIPGCFSAGDDLDDAMAMAREAIEGHFEILAEDGAAIPPANKVTLHAANPQYAGRTWAL
IDIDVTKYLGKAQKLNITLPGYLLNRIDEYVLHHPEAKSRSGFLASAALKVLQQD

Download         Length: 408 bp

>AT99903 NZ_CP027708:c1550885-1550478 [Pseudomonas chlororaphis subsp. piscium]
ATGCTTTACCCGATTGCAATTTCAATGGGCGATGACGAACACGCCTGGGGCGTGGAAGTCCCCGACATTCCTGGCTGTTT
CTCGGCCGGCGACGACCTCGACGACGCCATGGCCATGGCCCGCGAAGCCATCGAAGGGCACTTCGAGATTCTCGCCGAAG
ACGGTGCCGCCATCCCGCCCGCCAACAAGGTCACCCTGCACGCGGCCAACCCTCAGTACGCAGGCCGCACCTGGGCGCTG
ATCGACATCGATGTCACCAAGTACCTGGGCAAGGCGCAGAAGCTCAACATCACCCTGCCCGGCTACCTGCTGAACCGCAT
CGACGAATACGTGCTGCATCACCCGGAAGCAAAAAGCCGCTCGGGTTTTCTCGCTTCGGCTGCATTGAAGGTATTGCAGC
AAGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References