Detailed information of TA system TA099896

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1563754..1564376
• Replicon: chromosome
• Accession: NZ_CP027707
• Organism: Pseudomonas chlororaphis subsp. piscium strain DSM 21509

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: C4K38_RS07160
• Protein ID: WP_053277798.1
• Coordinates: 1564194..1564376 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: C4K38_RS07155
• Protein ID: WP_053277797.1
• Coordinates: 1563754..1564161 (-)
• Length: 136 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C4K38_RS07135	1559114..1560004	+	891	WP_053277793.1	LysR family transcriptional regulator	-
C4K38_RS07140	1560241..1562019	+	1779	WP_053277794.1	GGDEF and EAL domain-containing protein	-
C4K38_RS07145	1562053..1562967	-	915	WP_053277795.1	SGNH/GDSL hydrolase family protein	-
C4K38_RS07150	1563097..1563564	-	468	WP_053277796.1	GAF domain-containing protein	-
C4K38_RS07155	1563754..1564161	-	408	WP_053277797.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
C4K38_RS07160	1564194..1564376	-	183	WP_053277798.1	type II toxin-antitoxin system HicA family toxin	Toxin
C4K38_RS07165	1565442..1566158	+	717	WP_053277799.1	molecular chaperone	-
C4K38_RS07170	1566266..1567237	+	972	WP_053277800.1	fimbrial protein	-
C4K38_RS07175	1567406..1568010	-	605	Protein_1389	DUF4102 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-57)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6770.10 Da
• Isoelectric Point: 11.6709

>T99896 WP_053277798.1 NZ_CP027707:c1564376-1564194 [Pseudomonas chlororaphis subsp. piscium]
VNSRYLIGQIVADGWYLVRVRGSHHPFRPPSKPGLVTVPHPKKDLLRKTAISILKQALLM

Nucleotide

• Length: 183 bp

>T99896 NZ_CP027707:c1564376-1564194 [Pseudomonas chlororaphis subsp. piscium]
GTGAACAGTCGGTATTTGATCGGCCAAATCGTCGCAGACGGTTGGTATCTGGTCAGGGTCAGAGGCAGTCACCACCCTTT
CAGGCCCCCCAGTAAACCGGGGCTGGTGACAGTTCCACATCCCAAAAAGGACCTGCTGAGAAAAACCGCCATCAGCATTC
TGAAACAGGCGCTGCTCATGTGA

Antitoxin

Protein

• Length: 136 a.a.
• Molecular weight: 14594.56 Da
• Isoelectric Point: 4.3638

>AT99896 WP_053277797.1 NZ_CP027707:c1564161-1563754 [Pseudomonas chlororaphis subsp. piscium]
MLYPIAISMGDDEHAWGVEVPDIPGCFSAGDDLDDAMAMAREAIEGHFEILAEDGAAIPSANKVTLHAANPQYAGCTWAL
IDIDVTKYLGKAQKLNITLPGYLLNRIDEYVLHHPEAKSRSGFLASAALKVLQQD

Nucleotide

• Length: 408 bp

>AT99896 NZ_CP027707:c1564161-1563754 [Pseudomonas chlororaphis subsp. piscium]
ATGCTTTACCCGATTGCAATTTCAATGGGCGATGACGAACACGCCTGGGGCGTGGAAGTCCCCGACATTCCTGGCTGTTT
CTCGGCCGGTGACGACCTCGATGACGCCATGGCCATGGCCCGCGAAGCCATCGAAGGGCACTTCGAGATTCTCGCCGAAG
ACGGTGCCGCCATCCCGTCCGCCAACAAGGTCACCCTGCACGCGGCCAACCCTCAGTACGCAGGCTGCACCTGGGCGCTG
ATCGACATCGATGTCACCAAGTACCTGGGCAAGGCGCAGAAGCTCAACATCACCCTGCCCGGCTACCTGCTGAACCGCAT
CGACGAATACGTGCTGCATCACCCGGAAGCGAAGAGCCGCTCGGGTTTTCTCGCTTCGGCTGCATTGAAGGTATTGCAGC
AAGACTGA