Detailed information of TA system TA099895

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 315457..316070
• Replicon: chromosome
• Accession: NZ_CP027707
• Organism: Pseudomonas chlororaphis subsp. piscium strain DSM 21509

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A285EYZ4
• Locus tag: C4K38_RS01385
• Protein ID: WP_009041685.1
• Coordinates: 315457..315639 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: C4K38_RS01390
• Protein ID: WP_053277001.1
• Coordinates: 315669..316070 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C4K38_RS01365	311054..313018	+	1965	WP_164487030.1	choline transporter BetT	-
C4K38_RS01370	313127..313384	-	258	WP_053276984.1	hypothetical protein	-
C4K38_RS01375	313564..314304	-	741	WP_053276985.1	SDR family oxidoreductase	-
C4K38_RS01380	314442..315332	+	891	WP_053276986.1	LysR family transcriptional regulator	-
C4K38_RS01385	315457..315639	+	183	WP_009041685.1	type II toxin-antitoxin system HicA family toxin	Toxin
C4K38_RS01390	315669..316070	+	402	WP_053277001.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
C4K38_RS01395	316093..316509	-	417	WP_124345253.1	hypothetical protein	-
C4K38_RS01400	316658..317695	+	1038	WP_053276987.1	L-glyceraldehyde 3-phosphate reductase	-
C4K38_RS01405	317875..318102	-	228	WP_081001409.1	hypothetical protein	-
C4K38_RS01410	318199..319038	-	840	WP_053276989.1	taurine dioxygenase	-
C4K38_RS01415	319123..319962	-	840	WP_053276990.1	taurine ABC transporter permease TauC	-
C4K38_RS01420	319959..320753	-	795	WP_053276991.1	taurine ABC transporter ATP-binding subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6933.08 Da
• Isoelectric Point: 10.4588

>T99895 WP_009041685.1 NZ_CP027707:315457-315639 [Pseudomonas chlororaphis subsp. piscium]
MRSRELIRMIEEDGWYLIAVKGSHHQYKHLHKPGRVTIPHPDADLPRGTIHSILKQAGLK

Nucleotide

• Length: 183 bp

>T99895 NZ_CP027707:315457-315639 [Pseudomonas chlororaphis subsp. piscium]
ATGCGCAGTCGGGAACTGATCAGGATGATCGAGGAGGACGGGTGGTATCTGATCGCGGTCAAAGGCAGTCATCACCAGTA
CAAGCATCTGCACAAGCCGGGGCGGGTCACTATCCCTCACCCGGATGCGGATCTGCCCAGGGGCACGATCCACAGCATCT
TGAAACAGGCGGGCCTGAAATGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14582.41 Da
• Isoelectric Point: 4.9133

>AT99895 WP_053277001.1 NZ_CP027707:315669-316070 [Pseudomonas chlororaphis subsp. piscium]
MKFPVVLHKDADSGYGVIVPDVPGCFSAGHTAAQAFENVKEALSLHYEGLVADGEPLPQVHEVDVHIDNPDYAGGVWGVV
EFDITPYFGKAVRFNATLPEQLLERIDQTVKRDQRYRSRSGFLAAAALRELSA

Nucleotide

• Length: 402 bp

>AT99895 NZ_CP027707:315669-316070 [Pseudomonas chlororaphis subsp. piscium]
ATGAAATTCCCGGTCGTGCTGCACAAGGATGCCGACTCCGGATATGGAGTGATCGTCCCCGATGTGCCGGGCTGTTTTTC
CGCCGGTCATACCGCTGCGCAAGCCTTCGAGAATGTGAAAGAAGCCCTGTCGCTGCACTACGAAGGCCTGGTTGCCGATG
GTGAGCCGCTGCCCCAGGTGCATGAGGTCGACGTGCATATCGACAATCCCGACTACGCCGGCGGCGTATGGGGGGTGGTC
GAGTTCGATATCACACCGTACTTCGGCAAGGCGGTGCGTTTTAATGCGACGTTGCCGGAGCAACTGTTGGAGCGCATCGA
CCAGACAGTGAAGCGCGACCAGCGTTACCGTTCGCGCTCGGGTTTTCTCGCGGCAGCGGCACTGCGCGAGCTCTCCGCCT
AG

Structures

Toxin

• AlphaFold DB: A0A285EYZ4