Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RHH
Location 1532952..1533465 Replicon chromosome
Accession NZ_CP027706
Organism Pseudomonas sp. CMR12a

Toxin (Protein)


Gene name relE Uniprot ID A0A6G6ZW42
Locus tag C4K39_RS07080 Protein ID WP_068582176.1
Coordinates 1532952..1533236 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7X1FE57
Locus tag C4K39_RS07085 Protein ID WP_068582179.1
Coordinates 1533226..1533465 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4K39_RS07055 1528112..1528999 - 888 WP_124345962.1 dihydrodipicolinate synthase family protein -
C4K39_RS07060 1529033..1529815 - 783 WP_124345963.1 aldolase -
C4K39_RS07065 1529977..1530519 + 543 WP_124345964.1 XRE family transcriptional regulator -
C4K39_RS07070 1530583..1531602 - 1020 WP_068582209.1 DUF4917 family protein -
C4K39_RS07075 1531760..1532908 + 1149 WP_124345965.1 L-threonine dehydrogenase -
C4K39_RS07080 1532952..1533236 - 285 WP_068582176.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C4K39_RS07085 1533226..1533465 - 240 WP_068582179.1 ribbon-helix-helix protein, CopG family Antitoxin
C4K39_RS07090 1533662..1534402 + 741 WP_124345966.1 hypothetical protein -
C4K39_RS07095 1534413..1535138 + 726 WP_124345967.1 hypothetical protein -
C4K39_RS07100 1535142..1535585 + 444 WP_068582188.1 fosfomycin resistance glutathione transferase -
C4K39_RS07105 1535687..1536325 + 639 WP_068582191.1 LysE family translocator -
C4K39_RS07110 1536435..1537784 + 1350 WP_068582196.1 GGDEF domain-containing protein -
C4K39_RS07115 1537908..1538432 + 525 WP_124345968.1 DUF4142 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-41)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11100.77 Da        Isoelectric Point: 11.5026

>T99891 WP_068582176.1 NZ_CP027706:c1533236-1532952 [Pseudomonas sp. CMR12a]
MHIEWLRTALKNLDDEARYIAQDNPEAAREFVQTLLTGIGHLARFPASGREGRLPGTREWVVPGWPYLIPYRVRGSRLQI
LRIFHTRRQPPQRW

Download         Length: 285 bp

>T99891 NZ_CP027706:c1533236-1532952 [Pseudomonas sp. CMR12a]
ATGCACATTGAGTGGCTGCGAACAGCCCTGAAAAACCTGGATGACGAGGCGCGTTACATTGCCCAGGACAATCCTGAAGC
CGCCAGGGAGTTCGTGCAGACCCTGCTCACTGGCATCGGGCATTTGGCCCGTTTTCCGGCCAGCGGGCGCGAAGGTCGGC
TACCCGGTACCCGAGAATGGGTCGTGCCTGGATGGCCTTATCTGATTCCCTATCGAGTGCGCGGTAGTCGGTTGCAGATA
CTGCGCATCTTCCACACTCGCCGCCAGCCTCCGCAGCGCTGGTAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8537.68 Da        Isoelectric Point: 4.4143

>AT99891 WP_068582179.1 NZ_CP027706:c1533465-1533226 [Pseudomonas sp. CMR12a]
MSIMSLRLPDEMAETLALLAKATGRSKSFLAVDALREYLAREAWQIEEIQKALGEADAGDFASAEEVAAITGKWTGNAH

Download         Length: 240 bp

>AT99891 NZ_CP027706:c1533465-1533226 [Pseudomonas sp. CMR12a]
ATGTCCATCATGTCCCTGCGCCTGCCCGACGAAATGGCTGAAACCCTTGCTCTGCTGGCGAAAGCGACAGGGCGTAGCAA
GTCGTTCCTGGCGGTGGATGCGTTGCGTGAATACCTCGCCCGGGAAGCCTGGCAGATCGAGGAGATCCAAAAGGCGCTCG
GGGAAGCTGATGCGGGGGATTTCGCCAGCGCGGAGGAAGTAGCGGCCATCACGGGTAAATGGACCGGCAATGCACATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6G6ZW42

Antitoxin

Source ID Structure
AlphaFold DB A0A7X1FE57

References