Detailed information of TA system TA099890

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 956208..956746
• Replicon: chromosome
• Accession: NZ_CP027706
• Organism: Pseudomonas sp. CMR12a

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A6G6ZTT3
• Locus tag: C4K39_RS04290
• Protein ID: WP_068575728.1
• Coordinates: 956468..956746 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: C4K39_RS04285
• Protein ID: WP_083236103.1
• Coordinates: 956208..956471 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C4K39_RS04270	952175..954475	-	2301	WP_124345737.1	TonB-dependent siderophore receptor	-
C4K39_RS04275	954684..955364	+	681	WP_068575723.1	Fe2+-dependent dioxygenase	-
C4K39_RS04280	955368..956153	+	786	WP_124345738.1	sel1 repeat family protein	-
C4K39_RS04285	956208..956471	+	264	WP_083236103.1	ribbon-helix-helix domain-containing protein	Antitoxin
C4K39_RS04290	956468..956746	+	279	WP_068575728.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
C4K39_RS04295	956831..957994	-	1164	WP_068575730.1	type III PLP-dependent enzyme	-
C4K39_RS04300	958672..959829	-	1158	WP_068575732.1	ABC transporter ATP-binding protein	-
C4K39_RS04305	959826..960494	-	669	WP_068575734.1	ABC transporter permease	-
C4K39_RS04310	960507..961400	-	894	WP_124345739.1	glycine betaine ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Ribbon-helix-helix protein, CopG (7-44)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10787.55 Da
• Isoelectric Point: 10.8284

>T99890 WP_068575728.1 NZ_CP027706:956468-956746 [Pseudomonas sp. CMR12a]
MRQLKWTSKALSDLARLFEFLAQVNRSAAARTVQSLVRAPDALLSNPRLGEQLEEFKPKDVRRLLVGHYEVRYEIQGMVL
SILRIWHVREDR

Nucleotide

• Length: 279 bp

>T99890 NZ_CP027706:956468-956746 [Pseudomonas sp. CMR12a]
ATGAGACAGCTGAAATGGACGAGCAAGGCGCTATCCGATCTGGCTCGGCTTTTTGAATTTCTCGCTCAGGTTAATCGCTC
GGCTGCTGCTCGGACCGTGCAATCTCTCGTGCGGGCTCCAGATGCGCTGCTATCTAACCCTCGATTGGGAGAGCAGTTGG
AGGAGTTCAAGCCGAAGGATGTTCGACGGTTGTTGGTGGGGCATTACGAGGTGCGTTATGAGATTCAAGGCATGGTCTTG
TCCATCCTGCGTATTTGGCATGTCCGGGAAGATCGTTGA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9691.09 Da
• Isoelectric Point: 5.0878

>AT99890 WP_083236103.1 NZ_CP027706:956208-956471 [Pseudomonas sp. CMR12a]
MPATKVLTAHIPLDLADKVDQLASRLERSRAWIVKQALVAWVDQEEERRRLTLEALADVDAGRVVDHQSVLAWAESLSGD
NPLPLPK

Nucleotide

• Length: 264 bp

>AT99890 NZ_CP027706:956208-956471 [Pseudomonas sp. CMR12a]
ATGCCCGCGACAAAAGTACTGACCGCCCACATTCCCTTGGATCTGGCGGATAAGGTCGATCAACTGGCTTCTCGCCTGGA
GCGCTCCCGTGCCTGGATCGTGAAGCAAGCATTGGTAGCCTGGGTTGACCAGGAAGAAGAGCGCCGCCGACTGACGCTTG
AGGCCTTGGCAGATGTCGATGCTGGAAGGGTTGTCGATCATCAGTCCGTGCTGGCTTGGGCAGAGAGTCTGTCTGGCGAC
AACCCTCTGCCTTTACCAAAATGA

Structures

Toxin

• AlphaFold DB: A0A6G6ZTT3