Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 442712..443513 Replicon chromosome
Accession NZ_CP027701
Organism Escherichia coli strain 675SK2

Toxin (Protein)


Gene name yeeV Uniprot ID D8EBK0
Locus tag CYU58_RS02165 Protein ID WP_001094436.1
Coordinates 442712..443089 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B7MN76
Locus tag CYU58_RS02170 Protein ID WP_015953067.1
Coordinates 443136..443513 (-) Length 126 a.a.

Genomic Context

CYU58_RS02140CYU58_RS02145CYU58_RS02135CYU58_RS02150CYU58_RS02155CYU58_RS02160CYU58_RS02165CYU58_RS02170CYU58_RS02175CYU58_RS02180CYU58_RS02190CYU58_RS02195CYU58_RS02200CYU58_RS02205CYU58_RS02210
Location: 438923..440422 (1500 bp)
Type: Others
Protein ID: WP_029700729.1
Location: 440419..441174 (756 bp)
Type: Others
Protein ID: WP_000065240.1
Location: 438671..438832 (162 bp)
Type: Others
Protein ID: Protein_367
Location: 441238..441933 (696 bp)
Type: Others
Protein ID: Protein_370
Location: 442018..442215 (198 bp)
Type: Others
Protein ID: WP_000839254.1
Location: 442227..442715 (489 bp)
Type: Others
Protein ID: WP_000761714.1
Location: 442712..443089 (378 bp)
Type: Toxin
Protein ID: WP_001094436.1
Location: 443136..443513 (378 bp)
Type: Antitoxin
Protein ID: WP_015953067.1
Location: 443592..443813 (222 bp)
Type: Others
Protein ID: WP_000692312.1
Location: 443882..444358 (477 bp)
Type: Others
Protein ID: WP_001186756.1
Location: 444373..444858 (486 bp)
Type: Others
Protein ID: WP_000860054.1
Location: 444949..445767 (819 bp)
Type: Others
Protein ID: WP_001175142.1
Location: 445857..446090 (234 bp)
Type: Others
Protein ID: WP_001278287.1
Location: 446096..446773 (678 bp)
Type: Others
Protein ID: WP_001097312.1
Location: 446921..447601 (681 bp)
Type: Others
Protein ID: WP_001282927.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CYU58_RS02135438671..438832-162Protein_367DUF4942 domain-containing protein-
CYU58_RS02140438923..440422+1500WP_029700729.1IS21-like element ISEc10 family transposase-
CYU58_RS02145440419..441174+756WP_000065240.1IS21-like element ISEc10 family helper ATPase IstB-
CYU58_RS02150441238..441933-696Protein_370DUF4942 domain-containing protein-
CYU58_RS02155442018..442215-198WP_000839254.1DUF957 domain-containing protein-
CYU58_RS02160442227..442715-489WP_000761714.1hypothetical protein-
CYU58_RS02165442712..443089-378WP_001094436.1TA system toxin CbtA family proteinToxin
CYU58_RS02170443136..443513-378WP_015953067.1type IV toxin-antitoxin system toxin CbtAAntitoxin
CYU58_RS02175443592..443813-222WP_000692312.1DUF987 domain-containing protein-
CYU58_RS02180443882..444358-477WP_001186756.1RadC family protein-
CYU58_RS02190444373..444858-486WP_000860054.1antirestriction protein-
CYU58_RS02195444949..445767-819WP_001175142.1DUF945 domain-containing protein-
CYU58_RS02200445857..446090-234WP_001278287.1DUF905 family protein-
CYU58_RS02205446096..446773-678WP_001097312.1hypothetical protein-
CYU58_RS02210446921..447601-681WP_001282927.1WYL domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--427234..45811630882


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13958.84 Da        Isoelectric Point: 6.8603

>T99848 WP_001094436.1 NZ_CP027701:c443089-442712 [Escherichia coli]
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKQ

Download         Length: 378 bp

>T99848 NZ_CP027701:c443089-442712 [Escherichia coli]
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCAACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACAATGA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13766.60 Da        Isoelectric Point: 6.2021

>AT99848 WP_015953067.1 NZ_CP027701:c443513-443136 [Escherichia coli]
VSDTLPGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTITLYAKGLTCEADTLGSCGYVYLAVYPTPAAPAITV

Download         Length: 378 bp

>AT99848 NZ_CP027701:c443513-443136 [Escherichia coli]
GTGTCAGACACACTGCCCGGGACAACGCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCATCACACTGTATGCGAAAGGGCTGACCTGCGAAGCCGATACCCTTGGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCAGCGCCCGCAATCACCGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0E2L1N0

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A5Z3CIS0

References