Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ParST/RES-Xre
Location 71088..71887 Replicon plasmid unnamed2
Accession NZ_CP027671
Organism Simplicispira suum strain SC1-8

Toxin (Protein)


Gene name ParT Uniprot ID -
Locus tag C6571_RS19285 Protein ID WP_106448507.1
Coordinates 71414..71887 (+) Length 158 a.a.

Antitoxin (Protein)


Gene name ParS Uniprot ID -
Locus tag C6571_RS19280 Protein ID WP_106448536.1
Coordinates 71088..71414 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6571_RS19260 67107..68354 + 1248 WP_211300766.1 AAA family ATPase -
C6571_RS19265 68825..69712 + 888 WP_170094881.1 ParB/RepB/Spo0J family partition protein -
C6571_RS19270 69876..70235 + 360 WP_106448506.1 hypothetical protein -
C6571_RS19275 70468..70728 - 261 WP_106448535.1 TraY domain-containing protein -
C6571_RS19280 71088..71414 + 327 WP_106448536.1 DUF2384 domain-containing protein Antitoxin
C6571_RS19285 71414..71887 + 474 WP_106448507.1 RES family NAD+ phosphorylase Toxin
C6571_RS19290 72397..73434 - 1038 WP_146139395.1 hypothetical protein -
C6571_RS19295 73481..74008 - 528 WP_106448509.1 hypothetical protein -
C6571_RS19300 74151..74681 - 531 WP_106448510.1 hypothetical protein -
C6571_RS19305 74813..75667 - 855 WP_146139396.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..97155 97155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(4-144)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(61-105)


Sequences

Toxin        


Download         Length: 158 a.a.        Molecular weight: 17533.98 Da        Isoelectric Point: 6.8823

>T99846 WP_106448507.1 NZ_CP027671:71414-71887 [Simplicispira suum]
MPYVWRIGTDTPDYTSDDLSGIGAEKTGGRWNRKGHPVLYTASSISLAALETLGHLGTGGLPLNRYLVRIEVPDDVWNAR
ERKPALTLPVGWDARPEGMVSLDLGDQWLKELSSVLLEVPSVVVPEENNVLVNPRHPHAGKITATKMRLWQYDQRIR

Download         Length: 474 bp

>T99846 NZ_CP027671:71414-71887 [Simplicispira suum]
ATGCCTTACGTTTGGCGAATTGGCACGGACACGCCAGATTACACCTCGGACGATCTGTCGGGTATCGGAGCTGAAAAAAC
CGGGGGGAGATGGAACAGGAAAGGGCATCCTGTGCTGTATACGGCATCCAGCATTTCTCTGGCCGCGTTAGAAACGCTGG
GGCACCTTGGGACCGGCGGGCTGCCTCTCAATCGGTATTTGGTGCGGATTGAGGTGCCTGATGATGTCTGGAATGCGCGA
GAACGAAAGCCTGCCCTGACGCTGCCGGTGGGGTGGGATGCGAGACCAGAGGGAATGGTGTCGTTGGATCTGGGTGATCA
GTGGCTCAAGGAGCTGAGCAGCGTGTTGTTGGAAGTGCCCTCAGTCGTCGTCCCGGAAGAGAACAACGTACTCGTGAACC
CGCGCCATCCTCACGCTGGCAAGATCACTGCGACCAAAATGCGGCTCTGGCAATACGACCAGCGTATTCGCTGA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 11735.47 Da        Isoelectric Point: 10.0013

>AT99846 WP_106448536.1 NZ_CP027671:71088-71414 [Simplicispira suum]
MGMPKDKLYITLGLPRASVQRKASQDKRLSPDASSRVLGMKRLIGQVQSIVEESGNLKGFDAAAWVATWLDQEAEVLGGQ
KPSKFMDTPEGQLLVSQLIARTQSGAYS

Download         Length: 327 bp

>AT99846 NZ_CP027671:71088-71414 [Simplicispira suum]
ATGGGGATGCCCAAGGATAAGCTTTACATCACTTTGGGGCTTCCTCGCGCCAGTGTGCAGCGCAAGGCGAGCCAGGATAA
GAGGTTGTCGCCAGATGCGTCCTCGCGGGTCCTTGGCATGAAGCGTCTGATTGGGCAAGTCCAATCCATCGTGGAGGAGT
CCGGCAATCTAAAAGGGTTCGACGCTGCGGCGTGGGTGGCGACATGGCTTGATCAAGAGGCAGAGGTACTGGGGGGGCAA
AAGCCCAGCAAATTTATGGACACGCCAGAGGGACAGCTGTTGGTCTCTCAGCTCATAGCGCGCACCCAGAGCGGGGCCTA
CTCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References