Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 36594..37135 Replicon plasmid unnamed1
Accession NZ_CP027670
Organism Simplicispira suum strain SC1-8

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag C6571_RS18425 Protein ID WP_211300764.1
Coordinates 36812..37135 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag C6571_RS18420 Protein ID WP_106448363.1
Coordinates 36594..36815 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6571_RS18385 32173..32529 + 357 WP_012435589.1 cupin domain-containing protein -
C6571_RS18390 33098..33430 - 333 WP_013516307.1 hypothetical protein -
C6571_RS18395 33773..34090 + 318 WP_106448358.1 type II toxin-antitoxin system PrlF family antitoxin -
C6571_RS18400 34090..34548 + 459 WP_106448359.1 type II toxin-antitoxin system YhaV family toxin -
C6571_RS18405 34579..35037 - 459 WP_106448360.1 helix-turn-helix domain-containing protein -
C6571_RS18410 35195..35575 + 381 WP_106448361.1 HU family DNA-binding protein -
C6571_RS18415 35676..36518 - 843 WP_106448362.1 restriction endonuclease -
C6571_RS18420 36594..36815 + 222 WP_106448363.1 antitoxin MazE family protein Antitoxin
C6571_RS18425 36812..37135 + 324 WP_211300764.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
C6571_RS18430 37135..39066 + 1932 WP_106448364.1 site-specific DNA-methyltransferase -
C6571_RS18435 39090..41804 + 2715 WP_106448365.1 DEAD/DEAH box helicase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid cmlA1 / aadA2 / sul1 - 1..140077 140077


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-106)

Antitoxin

Antitoxin MazE-like

(9-72)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 11643.54 Da        Isoelectric Point: 4.7871

>T99845 WP_211300764.1 NZ_CP027670:36812-37135 [Simplicispira suum]
MIQRGDIVAVSIQGDYGKPRPALVIQSDLLEELQSVVLCPITSELRDAAFRVTVEPTPANGLSALSQVMADKISTLPRNK
LSEPFGRLDDDRMKAVERALLLVTGLI

Download         Length: 324 bp

>T99845 NZ_CP027670:36812-37135 [Simplicispira suum]
ATGATCCAGCGCGGCGACATCGTTGCCGTCTCTATCCAGGGCGACTACGGCAAACCGCGCCCTGCCCTGGTTATCCAGTC
CGATCTGCTCGAAGAGCTGCAAAGCGTCGTGCTCTGCCCGATCACCAGCGAGTTGCGTGATGCGGCGTTTCGCGTGACCG
TGGAACCCACCCCTGCCAATGGGCTGAGCGCGTTATCGCAGGTGATGGCCGACAAGATTTCGACACTGCCCCGCAACAAG
CTTAGCGAGCCATTCGGCCGTCTCGATGACGATCGCATGAAGGCGGTTGAGCGCGCACTCCTACTCGTAACTGGACTCAT
TTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8372.35 Da        Isoelectric Point: 5.8148

>AT99845 WP_106448363.1 NZ_CP027670:36594-36815 [Simplicispira suum]
MSTSTTTTDKVARYRERMRAAGLRPVQFWVPDTRSAEFMARVREQCQRLSGDPQEEQALGFAQAAVEHIEGWE

Download         Length: 222 bp

>AT99845 NZ_CP027670:36594-36815 [Simplicispira suum]
ATGTCAACCTCCACCACTACGACAGACAAGGTGGCACGCTACCGCGAGCGCATGCGCGCCGCAGGCCTGCGACCGGTGCA
GTTCTGGGTACCCGACACCCGATCGGCCGAATTCATGGCACGTGTGCGTGAACAATGCCAGCGCCTGAGCGGGGATCCTC
AGGAAGAACAGGCGCTGGGCTTTGCGCAAGCAGCGGTCGAGCATATTGAGGGCTGGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References