Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 3742044..3743571 Replicon chromosome
Accession NZ_CP027669
Organism Simplicispira suum strain SC1-8

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag C6571_RS17325 Protein ID WP_106447799.1
Coordinates 3742044..3743348 (-) Length 435 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag C6571_RS17330 Protein ID WP_106447800.1
Coordinates 3743350..3743571 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6571_RS19890 3737539..3737844 - 306 WP_211300667.1 winged helix-turn-helix transcriptional regulator -
C6571_RS17315 3737807..3739024 - 1218 WP_211300668.1 putative DNA binding domain-containing protein -
C6571_RS19895 3739111..3741876 - 2766 WP_106447798.1 N-6 DNA methylase -
C6571_RS17325 3742044..3743348 - 1305 WP_106447799.1 type II toxin-antitoxin system HipA family toxin Toxin
C6571_RS17330 3743350..3743571 - 222 WP_106447800.1 helix-turn-helix transcriptional regulator Antitoxin
C6571_RS17335 3743741..3744163 - 423 WP_106447801.1 type II toxin-antitoxin system VapC family toxin -
C6571_RS17340 3744164..3744394 - 231 WP_106448318.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
C6571_RS17350 3744664..3745377 - 714 WP_106447802.1 DNA polymerase III subunit epsilon -
C6571_RS17355 3745403..3745741 - 339 WP_106447803.1 ISC system 2Fe-2S type ferredoxin -
C6571_RS17360 3745760..3747646 - 1887 WP_106447804.1 Fe-S protein assembly chaperone HscA -
C6571_RS17365 3747711..3748229 - 519 WP_106447805.1 Fe-S protein assembly co-chaperone HscB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(142-383)

Antitoxin

Transcription regulator, HipB-like

(11-67)


Sequences

Toxin        


Download         Length: 435 a.a.        Molecular weight: 46979.96 Da        Isoelectric Point: 7.3200

>T99842 WP_106447799.1 NZ_CP027669:c3743348-3742044 [Simplicispira suum]
MAGHLEVWLLGAHVGTLSQVEGRLGFAYAPDATTPLSQSLPIRSEPFDDRASRPFFAGLLPEGGKRKQIAKTLQISKQND
YALLDSLGGECAGAVTLLDAGQLPQPPDAPREVRWLDHAQLLQVLDEMPLRPMRAGEDGLRLSLAGAQDKLPVVLDADGL
RIGLPLNGSPSTHILKPPIAGVGGSVFNEAFCMALAGALKLDVARTQIRAIADGAQQRHYLLVERYDRQADVTERTSLPT
QRLHQEDFCQALGIVSEHKYQNEGGPGLAQAFALVRSATRPSALHTLKLLDYVVFNALVGNHDAHGKNFSLLYTPAGAVL
TPLYDALCTAVYPTLTEKMAMKIGSKYKFAEVMARHWEQFAIEAALSPAQVKKRILDIAKRLPDLARATQTAFQSQGTGH
PVIDQIVALIDQRCALTIRRLTAHPAEDAPLGTA

Download         Length: 1305 bp

>T99842 NZ_CP027669:c3743348-3742044 [Simplicispira suum]
ATGGCGGGGCATCTTGAAGTCTGGTTGCTGGGCGCGCACGTTGGCACCCTGTCACAAGTAGAGGGGCGGCTGGGCTTTGC
TTATGCACCCGACGCCACCACGCCTTTGTCGCAATCCCTCCCCATTCGCTCAGAACCCTTTGACGACAGGGCAAGCCGTC
CGTTCTTCGCCGGCTTGTTGCCCGAGGGTGGCAAGCGCAAGCAGATCGCCAAAACCTTGCAAATCTCCAAGCAGAACGAC
TACGCCCTGCTGGACAGCCTGGGCGGTGAGTGTGCCGGTGCCGTCACCTTGCTCGACGCCGGCCAGTTGCCTCAACCTCC
CGATGCCCCCCGTGAAGTGCGCTGGCTGGACCACGCGCAACTGCTCCAGGTGCTCGATGAAATGCCTCTGCGCCCCATGC
GTGCGGGCGAAGACGGCCTGCGTCTCTCGCTGGCCGGTGCGCAAGACAAATTGCCGGTGGTGCTGGACGCGGACGGCCTT
CGCATCGGCCTGCCGCTCAACGGCTCACCCAGCACCCACATCCTCAAACCGCCCATTGCCGGGGTGGGCGGCAGCGTCTT
CAACGAAGCCTTTTGCATGGCACTGGCCGGCGCCTTGAAGCTGGATGTTGCCCGCACCCAGATTCGGGCCATTGCAGATG
GTGCGCAGCAGCGCCACTACCTGCTGGTAGAACGTTATGACCGGCAAGCCGACGTAACGGAACGAACGAGCCTGCCGACC
CAACGCCTGCACCAGGAAGACTTCTGCCAGGCGCTGGGCATCGTCTCTGAGCACAAATACCAAAACGAAGGCGGCCCGGG
CTTGGCCCAGGCATTTGCGCTGGTGCGCAGCGCCACCCGCCCCAGCGCGCTGCACACGCTCAAGTTGCTGGACTACGTGG
TGTTCAACGCCCTGGTCGGTAACCACGATGCCCACGGCAAGAACTTCTCGCTGCTCTACACCCCTGCGGGCGCCGTGCTC
ACGCCCCTGTACGACGCACTGTGCACCGCCGTCTACCCCACGCTCACCGAAAAAATGGCCATGAAAATCGGCAGCAAATA
CAAGTTTGCAGAAGTGATGGCACGGCACTGGGAGCAATTTGCCATCGAGGCCGCCTTGTCGCCCGCACAGGTCAAAAAGC
GCATTCTGGACATTGCCAAGCGCCTGCCCGACTTGGCGCGTGCCACCCAGACCGCGTTTCAGAGCCAGGGCACGGGCCAC
CCCGTCATCGACCAGATCGTTGCCCTGATCGACCAGCGCTGCGCCCTCACCATTCGCCGCCTCACGGCCCACCCGGCAGA
GGATGCGCCACTGGGCACCGCTTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 7440.81 Da        Isoelectric Point: 10.7410

>AT99842 WP_106447800.1 NZ_CP027669:c3743571-3743350 [Simplicispira suum]
MAITPTNSPEALGAAVLAARHRLGLTQPQLALAAGVGVRFIVELEAGKPTIRLQTLLKVLNTLGGSLAVEGLA

Download         Length: 222 bp

>AT99842 NZ_CP027669:c3743571-3743350 [Simplicispira suum]
ATGGCCATCACCCCCACCAACTCCCCCGAAGCACTGGGCGCCGCCGTTTTGGCTGCTCGCCACAGGCTGGGCCTCACCCA
ACCCCAATTGGCACTGGCGGCGGGCGTTGGCGTGCGCTTTATTGTGGAGCTGGAGGCCGGCAAGCCCACCATTCGCCTGC
AGACCCTGCTAAAAGTGCTGAACACACTGGGCGGCAGCCTCGCCGTCGAGGGTTTGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References