Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 3546228..3546826 Replicon chromosome
Accession NZ_CP027669
Organism Simplicispira suum strain SC1-8

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag C6571_RS16395 Protein ID WP_106447635.1
Coordinates 3546527..3546826 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag C6571_RS16390 Protein ID WP_106447634.1
Coordinates 3546228..3546527 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6571_RS16375 3541273..3543372 + 2100 WP_106447631.1 enoyl-CoA hydratase/isomerase family protein -
C6571_RS16380 3543390..3544883 + 1494 WP_211300662.1 M20 family peptidase -
C6571_RS16385 3544910..3546085 + 1176 WP_106447633.1 acetyl-CoA C-acyltransferase -
C6571_RS16390 3546228..3546527 - 300 WP_106447634.1 putative addiction module antidote protein Antitoxin
C6571_RS16395 3546527..3546826 - 300 WP_106447635.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C6571_RS16400 3547216..3547518 - 303 WP_106447636.1 hypothetical protein -
C6571_RS19570 3547597..3548298 - 702 WP_146139357.1 hypothetical protein -
C6571_RS16405 3548730..3549242 - 513 WP_106447637.1 DUF2059 domain-containing protein -
C6571_RS19575 3549308..3549748 - 441 WP_146139358.1 hypothetical protein -
C6571_RS19750 3549775..3549921 + 147 WP_170094777.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-94)

Antitoxin

Uncharacterized protein HI1420

(20-97)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11282.19 Da        Isoelectric Point: 10.3088

>T99841 WP_106447635.1 NZ_CP027669:c3546826-3546527 [Simplicispira suum]
MFTVRQTAEFQDWLDGLKDIKAQLRIVARLRLAEAGHLGDWKPVGNEVSEMRIALGPGYRLYFTKRQSILIVMLAGGDKS
SQARDIKRAQKILQLLELE

Download         Length: 300 bp

>T99841 NZ_CP027669:c3546826-3546527 [Simplicispira suum]
ATGTTCACGGTTCGGCAGACAGCAGAATTTCAAGACTGGCTTGATGGGCTGAAGGACATCAAGGCGCAACTGCGTATCGT
CGCCAGGTTGCGTCTGGCCGAAGCGGGCCATCTTGGCGACTGGAAGCCCGTCGGTAACGAGGTCTCGGAGATGCGGATTG
CGTTGGGTCCAGGCTATCGCCTGTACTTCACGAAACGCCAGAGCATCCTCATCGTCATGCTTGCTGGCGGAGACAAATCA
AGCCAGGCAAGAGACATCAAGCGGGCACAGAAAATTTTGCAACTATTGGAGCTTGAATGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10503.27 Da        Isoelectric Point: 9.8516

>AT99841 WP_106447634.1 NZ_CP027669:c3546527-3546228 [Simplicispira suum]
MSTSKTKPKLLAFDAARYLTDDAAIAEYMTAVLETENTDLLLLALSDVARAKGMAQVAKDAGLGRESLYKALAPGAKPRL
DTILKVARALGVKFTAHPA

Download         Length: 300 bp

>AT99841 NZ_CP027669:c3546527-3546228 [Simplicispira suum]
ATGAGCACTTCCAAGACCAAACCCAAGCTGCTGGCGTTCGATGCGGCTCGTTACCTCACCGATGATGCGGCCATTGCCGA
GTACATGACCGCAGTGTTGGAAACCGAAAACACGGATCTTCTTCTGCTTGCACTCAGCGACGTTGCGCGCGCCAAAGGCA
TGGCGCAAGTTGCCAAAGATGCCGGGCTCGGCCGGGAGAGCCTGTACAAGGCCCTCGCACCGGGGGCAAAGCCGCGCCTT
GACACCATTCTCAAGGTGGCTCGTGCGCTGGGTGTCAAGTTCACTGCGCATCCTGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References