Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3140070..3140737 Replicon chromosome
Accession NZ_CP027669
Organism Simplicispira suum strain SC1-8

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag C6571_RS14575 Protein ID WP_106447330.1
Coordinates 3140070..3140468 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag C6571_RS14580 Protein ID WP_106447331.1
Coordinates 3140465..3140737 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6571_RS14560 3135245..3136015 - 771 WP_146139340.1 hypothetical protein -
C6571_RS14565 3137201..3138076 + 876 WP_146139341.1 hypothetical protein -
C6571_RS14570 3138153..3140027 + 1875 WP_106447329.1 ATP-dependent helicase -
C6571_RS14575 3140070..3140468 - 399 WP_106447330.1 type II toxin-antitoxin system VapC family toxin Toxin
C6571_RS14580 3140465..3140737 - 273 WP_106447331.1 antitoxin Antitoxin
C6571_RS14585 3140825..3141235 - 411 WP_146139342.1 hypothetical protein -
C6571_RS14590 3141958..3142893 - 936 WP_106447333.1 CAP domain-containing protein -
C6571_RS14595 3143032..3143979 - 948 WP_106447334.1 NERD domain-containing protein -
C6571_RS14600 3144225..3145085 - 861 WP_106447335.1 hypothetical protein -
C6571_RS19530 3145110..3145733 - 624 WP_146139343.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(16-54)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 13929.20 Da        Isoelectric Point: 6.4552

>T99839 WP_106447330.1 NZ_CP027669:c3140468-3140070 [Simplicispira suum]
MNGYLLDTNIISDLIRNPSGPAARHIESIGSKNIYTSIIVAAELRYGCAKKASPKLLAKVEGLLETIPVLPLDVPADGKY
GAVRAELEAAGLPIGANDLLIAAHACALGLTLVTGNLREFSRIPGLALENWQ

Download         Length: 399 bp

>T99839 NZ_CP027669:c3140468-3140070 [Simplicispira suum]
TTGAACGGCTACCTGCTGGACACCAACATCATCAGCGACCTCATCCGCAATCCTTCAGGCCCTGCTGCCCGGCACATCGA
AAGTATCGGGAGCAAGAACATCTACACCAGCATCATCGTCGCGGCGGAGCTGCGCTATGGGTGCGCCAAGAAAGCCTCGC
CCAAACTCCTGGCCAAGGTGGAAGGCTTGCTCGAAACCATTCCTGTGCTCCCGCTGGACGTTCCTGCGGATGGCAAATAC
GGCGCAGTCCGTGCTGAGCTGGAGGCTGCTGGCTTGCCCATCGGCGCCAATGACCTGTTGATCGCTGCGCATGCCTGCGC
CCTGGGATTGACGCTGGTGACCGGCAACCTGCGTGAGTTCAGCCGCATCCCTGGCTTGGCGTTAGAAAACTGGCAGTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10354.78 Da        Isoelectric Point: 5.1768

>AT99839 WP_106447331.1 NZ_CP027669:c3140737-3140465 [Simplicispira suum]
MTALSRSSRPKEAKLFRNNRSQAVRIPVEFELPGDRVLIHREGDRLVIEPVTRPTNIIELLAQWRQEPPLGPEDQFPSIE
DAPARPEDIF

Download         Length: 273 bp

>AT99839 NZ_CP027669:c3140737-3140465 [Simplicispira suum]
ATGACCGCTCTATCGCGTTCCTCTCGGCCTAAAGAGGCAAAGCTTTTTCGCAACAACCGCAGTCAGGCGGTACGCATCCC
GGTCGAATTCGAGCTTCCCGGTGATCGCGTGCTGATCCACCGTGAGGGCGACAGGCTGGTCATTGAACCCGTGACCCGGC
CCACCAACATCATCGAACTGCTGGCCCAGTGGCGACAAGAGCCACCGCTCGGGCCAGAAGATCAATTCCCGAGCATCGAG
GACGCCCCGGCCCGACCGGAGGACATATTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References