Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) NpoTA/ParE(toxin)
Location 367573..368892 Replicon chromosome
Accession NZ_CP027669
Organism Simplicispira suum strain SC1-8

Toxin (Protein)


Gene name NpoT Uniprot ID -
Locus tag C6571_RS01765 Protein ID WP_106445176.1
Coordinates 368578..368892 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name NpoA Uniprot ID -
Locus tag C6571_RS01760 Protein ID WP_106445175.1
Coordinates 367573..368559 (-) Length 329 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6571_RS01740 363948..364889 - 942 WP_106445172.1 NAD-dependent epimerase/dehydratase family protein -
C6571_RS01745 364932..365993 + 1062 WP_106445173.1 CDP-6-deoxy-delta-3,4-glucoseen reductase -
C6571_RS01750 366016..366351 - 336 WP_106447974.1 four-helix bundle copper-binding protein -
C6571_RS01755 366482..367456 + 975 WP_106445174.1 tripartite tricarboxylate transporter substrate binding protein -
C6571_RS01760 367573..368559 - 987 WP_106445175.1 SDR family oxidoreductase Antitoxin
C6571_RS01765 368578..368892 - 315 WP_106445176.1 plasmid stabilization protein Toxin
C6571_RS01770 369035..369217 + 183 Protein_324 tripartite tricarboxylate transporter substrate binding protein -
C6571_RS01775 369298..369894 - 597 WP_106445177.1 2-hydroxychromene-2-carboxylate isomerase -
C6571_RS01780 370019..370765 - 747 WP_106445178.1 SDR family oxidoreductase -
C6571_RS01785 370844..371425 + 582 WP_106445179.1 TetR/AcrR family transcriptional regulator -
C6571_RS19435 371834..372265 + 432 WP_146139291.1 hypothetical protein -
C6571_RS01790 372307..373011 + 705 WP_211300686.1 HNH endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 295126..471727 176601


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11105.13 Da        Isoelectric Point: 10.6752

>T99838 WP_106445176.1 NZ_CP027669:c368892-368578 [Simplicispira suum]
MPQGDKSAYTDKQKRKAEHIEDSYEERGVSKEEAEKRAWATVNKESGGGNKSGSGRGTPENKSASKRGGKKGGEASAARS
AEERSASAKKAAATRKRNAEKAKH

Download         Length: 315 bp

>T99838 NZ_CP027669:c368892-368578 [Simplicispira suum]
ATGCCCCAAGGTGACAAGTCTGCCTATACCGACAAGCAGAAACGAAAAGCCGAGCACATCGAAGATTCGTACGAAGAGCG
CGGCGTGAGCAAGGAGGAAGCCGAAAAGCGCGCCTGGGCGACCGTGAACAAGGAATCCGGCGGCGGCAACAAGTCGGGCT
CCGGGCGCGGCACGCCGGAGAACAAGAGCGCGTCCAAGCGCGGCGGAAAAAAGGGTGGAGAGGCCTCGGCCGCACGGTCG
GCCGAAGAGCGCTCGGCGTCGGCAAAGAAAGCTGCGGCGACACGCAAGCGCAATGCGGAAAAAGCCAAGCACTGA

Antitoxin


Download         Length: 329 a.a.        Molecular weight: 35023.58 Da        Isoelectric Point: 6.8757

>AT99838 WP_106445175.1 NZ_CP027669:c368559-367573 [Simplicispira suum]
MTKTDPAKAAQATAKKAQRLQDGQDSRDAQADAKKPAARPAPGPGHDEPAPPLPAQHLRKPGRESELELPPRFEAKHYRG
SGKLEGLCALITGGDSGIGRAVAVLFAREGADVALLYLNEHEDAKETKRHVEAEGRRCLLISGDVKDRAFCQDATQKAVK
HFGRLDVLVNNAGFQLHADALEDITEERFDETFRTNIYGYFHMAQAALPHFKRGACIINTGSVTGISGSSHLIDYAATKG
AIHAFTLSLAKNLANKGIRVNAIAPGPVWTPLNPADKPADEIAEFGQDTDLGRPAQPEEIAPAYVFLAAPVCASYITGIV
LPVTGSVG

Download         Length: 987 bp

>AT99838 NZ_CP027669:c368559-367573 [Simplicispira suum]
ATGACCAAGACCGATCCGGCGAAGGCCGCGCAGGCCACCGCCAAGAAGGCGCAGCGCCTCCAAGATGGGCAGGACAGCCG
CGATGCGCAGGCTGACGCAAAGAAGCCCGCCGCCAGGCCGGCGCCCGGGCCGGGCCACGACGAGCCGGCGCCGCCGCTGC
CGGCGCAGCACCTGCGCAAGCCGGGTCGGGAATCCGAGTTGGAACTGCCCCCGCGCTTTGAGGCGAAGCACTACCGCGGC
AGCGGCAAGCTCGAGGGCCTCTGCGCGCTCATCACCGGCGGCGACTCGGGCATCGGCCGTGCGGTGGCGGTGCTCTTTGC
GCGCGAAGGTGCCGACGTTGCGTTGCTGTACTTGAACGAGCACGAAGACGCCAAGGAAACCAAACGCCATGTCGAGGCCG
AGGGCAGGCGCTGCCTGTTGATTTCGGGCGATGTGAAGGACCGGGCCTTTTGCCAGGACGCGACGCAAAAGGCTGTCAAG
CACTTTGGCCGTCTGGACGTGCTGGTCAACAACGCCGGCTTTCAGTTGCACGCCGATGCGCTGGAAGACATCACCGAAGA
GCGGTTCGATGAAACCTTCAGGACCAACATCTACGGCTACTTTCACATGGCGCAGGCGGCGCTGCCGCATTTCAAGCGCG
GCGCCTGCATCATCAATACCGGGTCGGTGACGGGTATCAGCGGCAGCAGCCACCTGATCGATTACGCCGCCACCAAGGGG
GCCATTCACGCCTTCACCCTGTCGCTGGCGAAGAACCTGGCGAACAAGGGCATACGCGTCAACGCCATTGCGCCCGGCCC
GGTCTGGACACCGCTGAACCCGGCCGACAAACCCGCCGACGAAATTGCCGAGTTTGGCCAGGACACCGACCTGGGTCGTC
CGGCGCAGCCCGAGGAAATCGCGCCAGCCTATGTCTTTCTCGCCGCGCCGGTGTGCGCGAGCTACATCACCGGCATCGTG
CTGCCTGTGACGGGCAGCGTCGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References