Detailed information of TA system TA099834

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 816776..817302
• Replicon: chromosome
• Accession: NZ_CP027668
• Organism: Phreatobacter cathodiphilus strain S-12

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: C6569_RS04040
• Protein ID: WP_106747632.1
• Coordinates: 817015..817302 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: C6569_RS04035
• Protein ID: WP_106747631.1
• Coordinates: 816776..817018 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C6569_RS04020	813207..813941	-	735	WP_106747629.1	hypothetical protein	-
C6569_RS04025	813950..816175	-	2226	WP_106747630.1	ABC transporter ATP-binding protein/permease	-
C6569_RS04030	816125..816736	+	612	WP_181313902.1	TIGR00730 family Rossman fold protein	-
C6569_RS04035	816776..817018	+	243	WP_106747631.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
C6569_RS04040	817015..817302	+	288	WP_106747632.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
C6569_RS04045	817307..818908	-	1602	WP_106747633.1	citramalate synthase	-
C6569_RS04050	819047..819523	-	477	WP_106747634.1	GFA family protein	-
C6569_RS04055	819981..821366	-	1386	WP_106747635.1	cysteine--tRNA ligase	-
C6569_RS04060	821546..821998	-	453	WP_106747636.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

• Antitoxin ParD (1-75)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10670.37 Da
• Isoelectric Point: 5.0760

>T99834 WP_106747632.1 NZ_CP027668:817015-817302 [Phreatobacter cathodiphilus]
MKLALTPAAEQDLSDIFDYSADTWGTDRAVAYVRMLQAAIERLLRFPELGRSAEAVGSGLRILMAGSHIVIYRLQPETIV
VIRILHQRMDVEESL

Nucleotide

• Length: 288 bp

>T99834 NZ_CP027668:817015-817302 [Phreatobacter cathodiphilus]
ATGAAGCTCGCGCTCACCCCCGCGGCCGAGCAAGACCTCTCCGACATCTTCGACTATTCGGCCGACACCTGGGGCACCGA
TCGTGCCGTGGCCTATGTGCGGATGCTGCAGGCGGCGATCGAGCGGCTGCTGCGGTTTCCAGAACTGGGTCGATCAGCCG
AGGCGGTCGGGTCGGGCCTGCGGATCCTGATGGCGGGATCACATATCGTCATCTACCGGCTACAGCCCGAAACGATCGTC
GTGATCCGCATCCTTCATCAGCGGATGGATGTCGAGGAAAGCCTCTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8565.58 Da
• Isoelectric Point: 5.6882

>AT99834 WP_106747631.1 NZ_CP027668:816776-817018 [Phreatobacter cathodiphilus]
MPKNTSVSLGDHFATFIDQRVAEGRYSSASEVVRAGLRLLEEHEAKLAALRAAVAEGEASGEARPFDFETFLASKLAGRG

Nucleotide

• Length: 243 bp

>AT99834 NZ_CP027668:816776-817018 [Phreatobacter cathodiphilus]
ATGCCCAAGAACACCTCCGTGAGCCTCGGCGATCATTTCGCGACTTTCATCGACCAGCGGGTCGCCGAGGGACGGTACAG
CTCGGCCAGCGAGGTGGTTCGGGCGGGGCTGCGGCTGCTCGAGGAGCACGAGGCGAAGCTTGCCGCGCTGCGGGCGGCGG
TGGCCGAGGGCGAAGCCAGCGGAGAGGCCCGCCCGTTCGACTTCGAGACGTTTCTCGCCAGCAAGCTGGCCGGGCGCGGA
TGA