Detailed information of TA system TA099829

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 2169954..2170603
• Replicon: chromosome
• Accession: NZ_CP027667
• Organism: Melaminivora sp. SC2-9

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: C6568_RS10265
• Protein ID: WP_106684041.1
• Coordinates: 2169954..2170370 (-)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: C6568_RS10270
• Protein ID: WP_106684042.1
• Coordinates: 2170370..2170603 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C6568_RS10240	2165371..2165988	+	618	WP_199792736.1	Uma2 family endonuclease	-
C6568_RS10245	2166174..2167217	-	1044	WP_106684038.1	Rpn family recombination-promoting nuclease/putative transposase	-
C6568_RS10250	2167360..2168460	-	1101	WP_106684039.1	transposase	-
C6568_RS10255	2168583..2169023	-	441	WP_199792737.1	pilin	-
C6568_RS10260	2169551..2169757	-	207	WP_106684040.1	BrnA antitoxin family protein	-
C6568_RS10265	2169954..2170370	-	417	WP_106684041.1	type II toxin-antitoxin system VapC family toxin	Toxin
C6568_RS10270	2170370..2170603	-	234	WP_106684042.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
C6568_RS10275	2170785..2171489	-	705	WP_106684043.1	FHA domain-containing protein	-
C6568_RS10280	2171598..2172467	-	870	WP_106684044.1	protein phosphatase 2C domain-containing protein	-
C6568_RS10285	2172651..2173544	-	894	WP_106684045.1	succinate--CoA ligase subunit alpha	-
C6568_RS10290	2173564..2174724	-	1161	WP_106684046.1	ADP-forming succinate--CoA ligase subunit beta	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (6-125)

Antitoxin

• SpoVT-AbrB domain (7-55)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 15064.30 Da
• Isoelectric Point: 7.4209

>T99829 WP_106684041.1 NZ_CP027667:c2170370-2169954 [Melaminivora sp. SC2-9]
MATLRYLLDTNIVIYVLKRRPIEVLSLFNQHASRMAISAITLAELVHGAEKSSQPSANLAVIDDFCSRLEVLPYGSKAAQ
HYGTIRAELERLGQPIGVNDLHLAAHARSEGLAMVTNNVREFGRVPGLVVENWVGSGS

Nucleotide

• Length: 417 bp

>T99829 NZ_CP027667:c2170370-2169954 [Melaminivora sp. SC2-9]
ATGGCGACGCTGCGCTACTTGCTGGACACCAACATCGTCATCTATGTCCTGAAGCGGCGGCCCATCGAAGTGCTGTCGCT
GTTCAATCAGCATGCCAGCCGCATGGCGATTTCCGCCATCACCCTCGCGGAGCTGGTGCACGGTGCGGAAAAGAGCAGCC
AGCCGAGCGCCAACTTGGCGGTCATCGACGACTTTTGCAGCCGCCTGGAAGTGCTGCCCTACGGCAGCAAGGCAGCGCAG
CACTACGGCACCATCCGCGCCGAGCTGGAGAGACTGGGCCAGCCCATCGGTGTCAACGATCTGCACCTCGCAGCCCATGC
GCGCAGCGAGGGGCTCGCCATGGTCACCAACAACGTGCGGGAGTTCGGGCGCGTGCCGGGGTTGGTGGTCGAGAACTGGG
TCGGCTCGGGCAGCTAA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8785.00 Da
• Isoelectric Point: 9.4986

>AT99829 WP_106684042.1 NZ_CP027667:c2170603-2170370 [Melaminivora sp. SC2-9]
MTITTVFINNRTQAVRLPVDMRLPDGVRQVRMRVRGSERIISPLDQSWDSFFIGGPQVSADFLPERASQQQPDRDAL

Nucleotide

• Length: 234 bp

>AT99829 NZ_CP027667:c2170603-2170370 [Melaminivora sp. SC2-9]
ATGACTATCACCACTGTGTTCATCAATAACCGGACGCAGGCCGTCCGGCTTCCGGTTGACATGCGCCTGCCCGACGGAGT
GCGCCAGGTCAGGATGCGCGTACGCGGCAGCGAGCGCATCATTTCGCCGCTGGATCAGAGTTGGGACAGCTTCTTCATCG
GCGGCCCCCAGGTGAGTGCCGATTTCCTGCCCGAGCGCGCCAGCCAGCAGCAGCCTGACCGGGATGCGCTTTGA