Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2169954..2170603 Replicon chromosome
Accession NZ_CP027667
Organism Melaminivora sp. SC2-9

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag C6568_RS10265 Protein ID WP_106684041.1
Coordinates 2169954..2170370 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag C6568_RS10270 Protein ID WP_106684042.1
Coordinates 2170370..2170603 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6568_RS10240 2165371..2165988 + 618 WP_199792736.1 Uma2 family endonuclease -
C6568_RS10245 2166174..2167217 - 1044 WP_106684038.1 Rpn family recombination-promoting nuclease/putative transposase -
C6568_RS10250 2167360..2168460 - 1101 WP_106684039.1 transposase -
C6568_RS10255 2168583..2169023 - 441 WP_199792737.1 pilin -
C6568_RS10260 2169551..2169757 - 207 WP_106684040.1 BrnA antitoxin family protein -
C6568_RS10265 2169954..2170370 - 417 WP_106684041.1 type II toxin-antitoxin system VapC family toxin Toxin
C6568_RS10270 2170370..2170603 - 234 WP_106684042.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
C6568_RS10275 2170785..2171489 - 705 WP_106684043.1 FHA domain-containing protein -
C6568_RS10280 2171598..2172467 - 870 WP_106684044.1 protein phosphatase 2C domain-containing protein -
C6568_RS10285 2172651..2173544 - 894 WP_106684045.1 succinate--CoA ligase subunit alpha -
C6568_RS10290 2173564..2174724 - 1161 WP_106684046.1 ADP-forming succinate--CoA ligase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-125)

Antitoxin

SpoVT-AbrB domain

(7-55)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15064.30 Da        Isoelectric Point: 7.4209

>T99829 WP_106684041.1 NZ_CP027667:c2170370-2169954 [Melaminivora sp. SC2-9]
MATLRYLLDTNIVIYVLKRRPIEVLSLFNQHASRMAISAITLAELVHGAEKSSQPSANLAVIDDFCSRLEVLPYGSKAAQ
HYGTIRAELERLGQPIGVNDLHLAAHARSEGLAMVTNNVREFGRVPGLVVENWVGSGS

Download         Length: 417 bp

>T99829 NZ_CP027667:c2170370-2169954 [Melaminivora sp. SC2-9]
ATGGCGACGCTGCGCTACTTGCTGGACACCAACATCGTCATCTATGTCCTGAAGCGGCGGCCCATCGAAGTGCTGTCGCT
GTTCAATCAGCATGCCAGCCGCATGGCGATTTCCGCCATCACCCTCGCGGAGCTGGTGCACGGTGCGGAAAAGAGCAGCC
AGCCGAGCGCCAACTTGGCGGTCATCGACGACTTTTGCAGCCGCCTGGAAGTGCTGCCCTACGGCAGCAAGGCAGCGCAG
CACTACGGCACCATCCGCGCCGAGCTGGAGAGACTGGGCCAGCCCATCGGTGTCAACGATCTGCACCTCGCAGCCCATGC
GCGCAGCGAGGGGCTCGCCATGGTCACCAACAACGTGCGGGAGTTCGGGCGCGTGCCGGGGTTGGTGGTCGAGAACTGGG
TCGGCTCGGGCAGCTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8785.00 Da        Isoelectric Point: 9.4986

>AT99829 WP_106684042.1 NZ_CP027667:c2170603-2170370 [Melaminivora sp. SC2-9]
MTITTVFINNRTQAVRLPVDMRLPDGVRQVRMRVRGSERIISPLDQSWDSFFIGGPQVSADFLPERASQQQPDRDAL

Download         Length: 234 bp

>AT99829 NZ_CP027667:c2170603-2170370 [Melaminivora sp. SC2-9]
ATGACTATCACCACTGTGTTCATCAATAACCGGACGCAGGCCGTCCGGCTTCCGGTTGACATGCGCCTGCCCGACGGAGT
GCGCCAGGTCAGGATGCGCGTACGCGGCAGCGAGCGCATCATTTCGCCGCTGGATCAGAGTTGGGACAGCTTCTTCATCG
GCGGCCCCCAGGTGAGTGCCGATTTCCTGCCCGAGCGCGCCAGCCAGCAGCAGCCTGACCGGGATGCGCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References