Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-PumB/upstrm_HI1419-dnstrm_HI1420
Location 2020756..2021409 Replicon chromosome
Accession NZ_CP027667
Organism Melaminivora sp. SC2-9

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag C6568_RS09635 Protein ID WP_199792731.1
Coordinates 2021062..2021409 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag C6568_RS09630 Protein ID WP_106683930.1
Coordinates 2020756..2021049 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6568_RS09615 2017136..2018857 + 1722 WP_106683927.1 nitrite reductase -
C6568_RS09620 2018944..2019843 - 900 WP_106683928.1 DMT family transporter -
C6568_RS09625 2019901..2020725 + 825 WP_106683929.1 orotidine-5'-phosphate decarboxylase -
C6568_RS09630 2020756..2021049 - 294 WP_106683930.1 putative addiction module antidote protein Antitoxin
C6568_RS09635 2021062..2021409 - 348 WP_199792731.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C6568_RS09640 2021452..2024508 - 3057 WP_106683931.1 excinuclease ABC subunit UvrA -
C6568_RS09645 2024626..2025561 - 936 WP_106683932.1 NAD(P)/FAD-dependent oxidoreductase -
C6568_RS09650 2025594..2025884 - 291 WP_106683933.1 N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(23-114)

Antitoxin

Uncharacterized protein HI1420

(4-92)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13143.28 Da        Isoelectric Point: 9.5321

>T99828 WP_199792731.1 NZ_CP027667:c2021409-2021062 [Melaminivora sp. SC2-9]
MLAAYRFLHVCILIYTITLVAVIHTTESFDRWFSALRDRMAQKRLQARIRRAELGNFGDCEPVGEGVSEMRIHYGPGYRV
YFTRRGLEVVILLAGGEKSTQQADIRAALELARQI

Download         Length: 348 bp

>T99828 NZ_CP027667:c2021409-2021062 [Melaminivora sp. SC2-9]
ATGCTGGCGGCGTACCGCTTTTTGCATGTTTGTATCCTAATTTATACAATTACCCTCGTGGCCGTCATCCATACCACCGA
AAGCTTTGACCGATGGTTTTCCGCTTTACGCGACCGCATGGCGCAAAAGCGACTTCAGGCGCGCATCCGCCGAGCGGAGT
TGGGAAACTTCGGTGACTGCGAGCCCGTCGGCGAAGGGGTGTCGGAGATGCGGATCCACTACGGGCCGGGCTATCGCGTC
TATTTCACACGGCGCGGCCTGGAGGTCGTGATTCTCCTGGCGGGCGGTGAAAAGTCCACCCAACAGGCAGACATCAGGGC
GGCGCTGGAGTTGGCGCGGCAGATTTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10464.06 Da        Isoelectric Point: 5.0621

>AT99828 WP_106683930.1 NZ_CP027667:c2021049-2020756 [Melaminivora sp. SC2-9]
MTLKLRKWDTVEHLQTEEDMVLYLQACMDEAGDDAAFIAAALGDIARARGMSQLAKDTGLGRESLYKALSGEGNPSFGTI
LKVMHALGIKLQPQALG

Download         Length: 294 bp

>AT99828 NZ_CP027667:c2021049-2020756 [Melaminivora sp. SC2-9]
ATGACCCTCAAACTGCGCAAGTGGGACACCGTAGAGCACCTCCAGACGGAAGAGGACATGGTGCTGTACCTGCAAGCCTG
CATGGATGAGGCCGGCGACGATGCCGCGTTCATTGCTGCGGCGCTCGGAGACATCGCTCGGGCGCGCGGCATGAGTCAGC
TCGCCAAAGACACGGGTCTGGGACGCGAGAGCCTGTACAAGGCGTTGTCCGGCGAGGGCAATCCCAGTTTCGGCACCATC
CTAAAAGTGATGCATGCGCTGGGCATCAAGCTACAACCCCAGGCACTCGGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References