Detailed information of TA system TA099823

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parE-PrpA/ParE-CC2985
• Location: 1261680..1262220
• Replicon: chromosome
• Accession: NZ_CP027667
• Organism: Melaminivora sp. SC2-9

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: C6568_RS05955
• Protein ID: WP_106683331.1
• Coordinates: 1261930..1262220 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: PrpA
• Uniprot ID: -
• Locus tag: C6568_RS05950
• Protein ID: WP_106683330.1
• Coordinates: 1261680..1261937 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C6568_RS05930	1256947..1257492	-	546	WP_106683326.1	HAD-IIIA family hydrolase	-
C6568_RS05935	1257489..1258130	-	642	WP_106683327.1	hypothetical protein	-
C6568_RS05940	1258127..1260304	-	2178	WP_106683328.1	glycine--tRNA ligase subunit beta	-
C6568_RS05945	1260493..1261449	-	957	WP_106683329.1	glycine--tRNA ligase subunit alpha	-
C6568_RS05950	1261680..1261937	+	258	WP_106683330.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
C6568_RS05955	1261930..1262220	+	291	WP_106683331.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
C6568_RS05960	1262338..1263315	-	978	WP_199792803.1	hypothetical protein	-
C6568_RS05965	1263450..1264856	-	1407	WP_106683332.1	dihydrolipoyl dehydrogenase	-
C6568_RS05970	1264863..1266230	-	1368	WP_106683333.1	2-oxo acid dehydrogenase subunit E2	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Antitoxin ParD (7-73)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11011.39 Da
• Isoelectric Point: 6.8696

>T99823 WP_106683331.1 NZ_CP027667:1261930-1262220 [Melaminivora sp. SC2-9]
MAELRLTPAALRDLETIWDYTEQRWGTAQALHYLDALETAFQSLAQAPESGQRCDAIRAGYRRSRVEQHGVYYRLEGDAV
VVVRVLHQRMDAGRHV

Nucleotide

• Length: 291 bp

>T99823 NZ_CP027667:1261930-1262220 [Melaminivora sp. SC2-9]
ATGGCTGAGTTGCGCCTGACGCCAGCGGCGCTACGCGATCTGGAAACCATTTGGGATTACACCGAGCAGCGCTGGGGCAC
GGCGCAAGCGCTGCATTACCTGGATGCGCTGGAGACAGCCTTCCAGTCGCTGGCGCAGGCGCCGGAATCCGGCCAGCGCT
GCGATGCCATTCGCGCCGGCTATCGCCGCAGCCGGGTGGAGCAGCACGGTGTGTATTACCGCCTGGAAGGCGACGCAGTA
GTTGTGGTGCGGGTACTGCACCAGCGTATGGATGCTGGCCGCCACGTGTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9546.74 Da
• Isoelectric Point: 8.7087

>AT99823 WP_106683330.1 NZ_CP027667:1261680-1261937 [Melaminivora sp. SC2-9]
MSTVRKTITLTDTQDGWVKAQIEAGHYTNDSEVIRALIRREQERMSELQALRSALLQGENSGEPQPFDAQAFRARMLAKR
SVANG

Nucleotide

• Length: 258 bp

>AT99823 NZ_CP027667:1261680-1261937 [Melaminivora sp. SC2-9]
ATGTCCACGGTGCGCAAAACCATCACTCTTACCGACACCCAGGATGGCTGGGTAAAGGCACAGATCGAGGCAGGGCATTA
CACCAACGACAGCGAAGTGATCCGCGCGCTGATCCGCCGCGAGCAGGAACGCATGTCGGAGTTGCAGGCACTGCGCTCGG
CCTTGCTGCAGGGCGAAAACAGTGGCGAACCTCAGCCATTTGACGCGCAGGCGTTCCGAGCTCGCATGCTGGCAAAGCGA
TCGGTTGCAAATGGCTGA